KR910016931A - 과콜레스테린혈증 치료제 - Google Patents
과콜레스테린혈증 치료제 Download PDFInfo
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- KR910016931A KR910016931A KR1019910004438A KR910004438A KR910016931A KR 910016931 A KR910016931 A KR 910016931A KR 1019910004438 A KR1019910004438 A KR 1019910004438A KR 910004438 A KR910004438 A KR 910004438A KR 910016931 A KR910016931 A KR 910016931A
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- compound
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- pharmaceutically acceptable
- fungal growth
- phenyl
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Dentistry (AREA)
- Botany (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Environmental Sciences (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 화합물 A의 1H NNR 스펙트럼을 나타낸 것이고, 제2도는 화합물의 B의 1H NMR 스펙트럼을 나타낸것이다.
Claims (11)
- 일반식(I)의 화합물 또는 Z1, Z2및 Z3중 적어도 하나가 수소인 일반식(I) 화합물의 약제학적으로 허용되는 염.상기식에서, Z1, Z2및 Z3는 서로 독립적으로, a)H, b)C1-C5알킬, c)i)페닐, ⅱ)메틸, 메톡시, 할로겐(Cl, Br, I, F)또는 하이드록시로 치환된 페닐 중에서 선택된 것으로 치환된 C1-C5알킬이다.
- 제1항에 있어서, 일반식(I)의 상대적 배위가 하기식과 같은 화합물.
- 제2항에 있어서, Z1, Z2및 Z3가 각각 수소인 화합물 또는 이의 약제학적으로 허용되는 염.
- 제2항에 있어서, Z1, Z2및 Z3가 각각 메틸인 화합물.
- 비독성 치료학적 유효량의 제1항의 화합물 및 약제학적으로 허용되는 담체를 함유함을 특징으로 하는 약제학적 조성물.
- 과콜레스테린혈증 치료를 필요로 하는 환자에게 비독성 치료학적 유효량의 제1항의 화합물을 투여함을 특징으로 하여 과콜레스테린혈증을 치료하는 방법.
- 다음 구조식의 화합물을 회수가능한 양으로 생산할 수 있는 MF5453(ATCC 20986) 또는 이의 활성 변이주의 컬쳐.
- 하기 구조식의 화합물을 형성하기에 적합한 조건하에서 MF5453(ATCC20986) 또는 이의 활성 변이주를 배양하여 상기 화합물을 회수함을 특징으로 하여 하기 구조식의 화합물을 제조하는 방법.
- 진균 생육을 억제할 지역에 일반식(I)의 화합물 또는 Z1, Z2및 Z3중 적어도 하나가 수소인 일반식(I) 화합물의 약제학적으로 허용되는 염을 항진균 유효량으로 적용함을 특징으로 하여 진균 생육을 억제하는 방법.상기식에서, Z1, Z2및 Z3는 서로 독립적으로, a)H, b)C1-C5알킬, c)i)페닐, ⅱ)메틸, 메톡시, 할로겐(Cl, Br, I, F)또는 하이드록시로 치환된 페닐 중에서 선택된 것으로 치환된 C1-C5알킬이다.
- 진균 생육 억제 치료를 필요로 하는 살아있는 유기체에게 제1항의 화합물을 경구적, 비경구적 또는 전신 투여함을 특징으로 하여 살아있는 유기체에서 진균 생육을 억제하는 방법.
- 제10항에 있어서, 화합물이 다음 화합물(1) 또는 (2)중에서 선택되는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49674990A | 1990-03-21 | 1990-03-21 | |
US49673190A | 1990-03-21 | 1990-03-21 | |
US?496,742? | 1990-03-21 | ||
US07/496,742 US5096923A (en) | 1990-03-21 | 1990-03-21 | Novel squalene synthetase inhibitors |
US?496,749? | 1990-03-21 | ||
US?496,731? | 1990-03-21 | ||
US07/626,071 US5053425A (en) | 1990-03-21 | 1990-12-11 | Novel anti-fungal compounds |
US?626,071? | 1990-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910016931A true KR910016931A (ko) | 1991-11-05 |
Family
ID=27504381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910004438A KR910016931A (ko) | 1990-03-21 | 1991-03-21 | 과콜레스테린혈증 치료제 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0450812B1 (ko) |
JP (1) | JPH04279589A (ko) |
KR (1) | KR910016931A (ko) |
AT (1) | ATE104982T1 (ko) |
AU (1) | AU640755B2 (ko) |
CA (1) | CA2038517A1 (ko) |
CS (1) | CS71991A2 (ko) |
DE (2) | DE450812T1 (ko) |
DK (1) | DK0450812T3 (ko) |
ES (1) | ES2052463T1 (ko) |
GR (1) | GR920300106T1 (ko) |
HU (1) | HUT61555A (ko) |
IE (1) | IE910924A1 (ko) |
IL (1) | IL97535A0 (ko) |
NO (1) | NO911121L (ko) |
NZ (1) | NZ237448A (ko) |
PT (1) | PT97077A (ko) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL97251A0 (en) * | 1990-03-21 | 1992-05-25 | Merck & Co Inc | Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them |
GB9100437D0 (en) * | 1991-01-09 | 1991-02-20 | Glaxo Group Ltd | Chemical compounds |
GB9105152D0 (en) * | 1991-03-12 | 1991-04-24 | Glaxo Group Ltd | Chemical compounds |
US5256689A (en) * | 1991-05-10 | 1993-10-26 | Merck & Co., Inc. | Cholesterol lowering compounds |
WO1992020336A2 (en) * | 1991-05-10 | 1992-11-26 | Merck & Co., Inc. | Novel cholesterol lowering compounds |
US5506262A (en) * | 1991-05-10 | 1996-04-09 | Merck & Co., Inc. | Cholesterol lowering compounds |
US5250424A (en) * | 1991-06-14 | 1993-10-05 | Merck & Co., Inc. | Processes for preparing novel squalene synthetase inhibitors |
US5200342A (en) * | 1991-06-14 | 1993-04-06 | Merck & Co., Inc. | Squalene synthetase inhibitors and processes therefrom |
CA2071723A1 (en) * | 1991-06-27 | 1992-12-28 | Gerald F. Bills | Culture of exserohilum rostratum and processes therefrom |
AU2230292A (en) * | 1991-07-16 | 1993-02-23 | Glaxo Group Limited | Cyclic ketal derivatives |
WO1993003038A1 (en) * | 1991-08-07 | 1993-02-18 | Merck & Co., Inc. | Novel cholesterol lowering compound |
GB9121380D0 (en) * | 1991-10-08 | 1991-11-20 | Glaxo Group Ltd | Chemical compounds |
GB2261374A (en) * | 1991-11-15 | 1993-05-19 | Merck & Co Inc | Inhibitors of farnesyl protein transferase as anti-cancer agents |
US5252471A (en) * | 1992-03-09 | 1993-10-12 | Merck & Co., Inc. | Directed biosynthesis of cholesterol lowering compounds |
WO1993017557A1 (en) * | 1992-03-09 | 1993-09-16 | Merck & Co., Inc. | Cholesterol lowering compounds produced by directed biosynthesis |
US5294627A (en) * | 1992-08-27 | 1994-03-15 | Merck & Co., Inc. | Directed biosynthesis of biologically active compounds |
GB9205140D0 (en) * | 1992-03-10 | 1992-04-22 | Glaxo Group Ltd | Chemical compounds |
GB9205136D0 (en) * | 1992-03-10 | 1992-04-22 | Glaxo Group Ltd | Chemical compounds |
EP0568946A1 (en) * | 1992-05-08 | 1993-11-10 | Takeda Chemical Industries, Ltd. | Compound TAN-1607A, its derivatives, their production, and use thereof |
US5260215A (en) * | 1992-07-20 | 1993-11-09 | Merck & Co., Inc. | Fungal microorganism ATCC 74167 capable of producing cholesterol lowering compounds |
US5283256A (en) * | 1992-07-22 | 1994-02-01 | Merck & Co., Inc. | Cholesterol-lowering agents |
US5322855A (en) * | 1992-10-19 | 1994-06-21 | Merck & Co., Inc. | Cholesterol lowering compounds |
US5447717A (en) * | 1993-02-25 | 1995-09-05 | Merck & Co., Inc. | Cholesterol-lowering agents |
US5430055A (en) * | 1994-04-08 | 1995-07-04 | Pfizer Inc. | Inhibitor of squalene synthase |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4276216A (en) * | 1980-07-31 | 1981-06-30 | Ortho Pharmaceutical Corporation | Synthesis of dioxabicyclo[3.2.1]octanes and oxepanes |
IL97251A0 (en) * | 1990-03-21 | 1992-05-25 | Merck & Co Inc | Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them |
-
1991
- 1991-03-13 IL IL97535A patent/IL97535A0/xx unknown
- 1991-03-15 NZ NZ237448A patent/NZ237448A/en unknown
- 1991-03-18 CA CA002038517A patent/CA2038517A1/en not_active Abandoned
- 1991-03-19 PT PT97077A patent/PT97077A/pt not_active Application Discontinuation
- 1991-03-19 CS CS91719A patent/CS71991A2/cs unknown
- 1991-03-20 AU AU73683/91A patent/AU640755B2/en not_active Ceased
- 1991-03-20 IE IE092491A patent/IE910924A1/en unknown
- 1991-03-20 HU HU91930A patent/HUT61555A/hu unknown
- 1991-03-20 NO NO91911121A patent/NO911121L/no unknown
- 1991-03-20 JP JP3081767A patent/JPH04279589A/ja active Pending
- 1991-03-21 DK DK91302458.4T patent/DK0450812T3/da active
- 1991-03-21 KR KR1019910004438A patent/KR910016931A/ko not_active Application Discontinuation
- 1991-03-21 EP EP91302458A patent/EP0450812B1/en not_active Expired - Lifetime
- 1991-03-21 DE DE199191302458T patent/DE450812T1/de active Pending
- 1991-03-21 ES ES91302458T patent/ES2052463T1/es active Pending
- 1991-03-21 DE DE69101802T patent/DE69101802T2/de not_active Expired - Fee Related
- 1991-03-21 AT AT9191302458T patent/ATE104982T1/de active
-
1993
- 1993-02-17 GR GR920300106T patent/GR920300106T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU640755B2 (en) | 1993-09-02 |
AU7368391A (en) | 1993-01-28 |
JPH04279589A (ja) | 1992-10-05 |
DE69101802T2 (de) | 1994-10-27 |
IE910924A1 (en) | 1991-09-25 |
HUT61555A (en) | 1993-01-28 |
CS71991A2 (en) | 1991-11-12 |
IL97535A0 (en) | 1992-06-21 |
ATE104982T1 (de) | 1994-05-15 |
HU910930D0 (en) | 1991-10-28 |
NO911121D0 (no) | 1991-03-20 |
EP0450812A1 (en) | 1991-10-09 |
NZ237448A (en) | 1993-11-25 |
GR920300106T1 (en) | 1993-02-17 |
NO911121L (no) | 1991-09-23 |
DE69101802D1 (de) | 1994-06-01 |
CA2038517A1 (en) | 1991-09-22 |
EP0450812B1 (en) | 1994-04-27 |
ES2052463T1 (es) | 1994-07-16 |
DE450812T1 (de) | 1992-11-26 |
DK0450812T3 (da) | 1994-06-06 |
PT97077A (pt) | 1991-11-29 |
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