KR930017886A - 알도오스 환원효소 저해물질 - Google Patents
알도오스 환원효소 저해물질 Download PDFInfo
- Publication number
- KR930017886A KR930017886A KR1019930002588A KR930002588A KR930017886A KR 930017886 A KR930017886 A KR 930017886A KR 1019930002588 A KR1019930002588 A KR 1019930002588A KR 930002588 A KR930002588 A KR 930002588A KR 930017886 A KR930017886 A KR 930017886A
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- KR
- South Korea
- Prior art keywords
- compound
- aldose reductase
- microorganism
- sirinoseta
- reductase inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
Abstract
본 발명은 캐토멜라 시르시노세타 RF-3192의 발효 생성물로 부터 분리된 하기 구조식의 알도오스 환원효소 저해물질에 관한 것이다.
〔상기식에서, R1은 (DH2)2COOH이고 R2는 페닐 또는 p-히드록시페닐이거나 R1및 R2는 함께 결합하여 구조식 :
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 하기 구조식(Ⅰ)의 화합물 또는 그의 염.〔상기식에서, R1은 (CH2)2COOH이고 R2는 페닐 또는 p-히드록시페닐이거나 R1및 R2는 함께 결합하여 구조식 :기를 형성한다.〕
- 제1항의 화합물을 생산하는 캐토멜라 시르시노세타 중에 속하는 미생물.
- 제2항에 있어서, 캐토멜라 시르시노세타 RF-3192 (FERM BP-3724)인 미생물.
- 캐토멜라 속에 속하고 제1항의 화합물을 생산하는 미생물을 배양하고, 상기 화합물을 배양 배지로부터 분리하고 단계로 구성되는 제1항의 화합물의 제조방법.
- 제1항에 화합물을 유효성분으로서 포함하는 알도오스 환원효소 저해제.
- 유효량의 제1항의 화합물을 제약학적으로 허용가능하고, 실질적으로 무독성인 담체 또는 부형제와 함께 포함하는 제약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP92-76140 | 1992-02-26 | ||
JP4076140A JP3068706B2 (ja) | 1992-02-26 | 1992-02-26 | アルド−ス還元酵素阻害物質 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR930017886A true KR930017886A (ko) | 1993-09-20 |
Family
ID=13596683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930002588A KR930017886A (ko) | 1992-02-26 | 1993-02-24 | 알도오스 환원효소 저해물질 |
Country Status (5)
Country | Link |
---|---|
US (1) | US5284870A (ko) |
EP (1) | EP0557939A1 (ko) |
JP (1) | JP3068706B2 (ko) |
KR (1) | KR930017886A (ko) |
TW (1) | TW265340B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6794408B2 (en) | 2002-01-29 | 2004-09-21 | Aventis Pharma Deutschland Gmbh | Drechsleranol derivatives, processes for their preparation and their use |
DE10203557A1 (de) * | 2002-01-29 | 2003-08-07 | Aventis Pharma Gmbh | Drechsleranol-Derivate, Verfahren zu deren Herstellung und deren Verwendung |
US9308206B2 (en) | 2004-08-23 | 2016-04-12 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating colon cancer |
US20100022625A1 (en) * | 2006-06-29 | 2010-01-28 | Srivastava Satish K | Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use |
US20060062822A1 (en) * | 2004-09-21 | 2006-03-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
PL2034850T3 (pl) * | 2006-06-06 | 2017-09-29 | Dsm Ip Assets B.V. | Nowy czynnik starterowy do wytwarzania sera |
JP6048919B2 (ja) * | 2011-11-18 | 2016-12-21 | ヤーマン株式会社 | ヘアーアイロン |
CN104447649B (zh) * | 2014-10-29 | 2016-08-17 | 辽宁大学 | 甲基萘并[1,2-b]呋喃酰胺类化合物及其药学上可接受的盐及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5916884A (ja) * | 1982-07-19 | 1984-01-28 | Fujisawa Pharmaceut Co Ltd | 新規フラン化合物 |
US5028537A (en) * | 1984-03-26 | 1991-07-02 | Merck & Co. Inc. | Novel antifungal substances and process for their production |
CA1335365C (en) * | 1988-02-13 | 1995-04-25 | Hidekazu Hosono | 2-pyranone derivative and process for production thereof |
-
1992
- 1992-02-26 JP JP4076140A patent/JP3068706B2/ja not_active Expired - Lifetime
-
1993
- 1993-02-09 US US08/015,356 patent/US5284870A/en not_active Expired - Fee Related
- 1993-02-19 TW TW082101173A patent/TW265340B/zh active
- 1993-02-23 EP EP93102793A patent/EP0557939A1/en not_active Ceased
- 1993-02-24 KR KR1019930002588A patent/KR930017886A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US5284870A (en) | 1994-02-08 |
JP3068706B2 (ja) | 2000-07-24 |
TW265340B (ko) | 1995-12-11 |
EP0557939A1 (en) | 1993-09-01 |
JPH05239048A (ja) | 1993-09-17 |
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