HUP9702151A2 - Eljárás Loracarbef-monohidrát előállítására - Google Patents

Eljárás Loracarbef-monohidrát előállítására

Info

Publication number
HUP9702151A2
HUP9702151A2 HU9702151A HUP9702151A HUP9702151A2 HU P9702151 A2 HUP9702151 A2 HU P9702151A2 HU 9702151 A HU9702151 A HU 9702151A HU P9702151 A HUP9702151 A HU P9702151A HU P9702151 A2 HUP9702151 A2 HU P9702151A2
Authority
HU
Hungary
Prior art keywords
preparing
loracarbef monohydrate
compound
formula
loracarbef
Prior art date
Application number
HU9702151A
Other languages
English (en)
Inventor
William C. Henning
Theodore R. Stout
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9702151A2 publication Critical patent/HUP9702151A2/hu
Publication of HUP9702151A3 publication Critical patent/HUP9702151A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya eljárás az (I) képletű vegyület kristályősmőnőhidrát főrmájának előállítására.A találmány szerint úgy járnak el, hőgy az (I) képletű vegyületkristályős anhidrát főrmáját körülbelül 90-100% relatívnedvességtartalmú közegbe helyezik. A találmány szerinti vegyületgyógyszerészetben alkalmazható.ŕ
HU9702151A 1995-03-01 1996-02-28 A process for preparing loracarbef monohydrate HUP9702151A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/396,948 US5580977A (en) 1995-03-01 1995-03-01 Process for preparing loracarbef monohydrate

Publications (2)

Publication Number Publication Date
HUP9702151A2 true HUP9702151A2 (hu) 1998-07-28
HUP9702151A3 HUP9702151A3 (en) 2001-01-29

Family

ID=23569249

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702151A HUP9702151A3 (en) 1995-03-01 1996-02-28 A process for preparing loracarbef monohydrate

Country Status (28)

Country Link
US (1) US5580977A (hu)
EP (1) EP0729959B1 (hu)
JP (1) JPH11501032A (hu)
KR (1) KR19980702666A (hu)
CN (1) CN1061349C (hu)
AR (1) AR002709A1 (hu)
AT (1) ATE184006T1 (hu)
AU (1) AU694639B2 (hu)
BR (1) BR9607308A (hu)
CA (1) CA2213812A1 (hu)
CO (1) CO4700429A1 (hu)
CZ (1) CZ272897A3 (hu)
DE (1) DE69603995T2 (hu)
DK (1) DK0729959T3 (hu)
ES (1) ES2135165T3 (hu)
GR (1) GR3031947T3 (hu)
HU (1) HUP9702151A3 (hu)
IL (1) IL117228A (hu)
NO (1) NO308471B1 (hu)
NZ (1) NZ304534A (hu)
PE (1) PE28097A1 (hu)
PL (1) PL322111A1 (hu)
RU (1) RU2160261C2 (hu)
SI (1) SI0729959T1 (hu)
TR (1) TR199700877T1 (hu)
TW (1) TW330205B (hu)
WO (1) WO1996026942A1 (hu)
ZA (1) ZA961341B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2222614T3 (es) 1997-11-12 2005-02-01 Mitsubishi Chemical Corporation Derivados de purina y medicina que los contiene como ingrediente activo.
KR100747106B1 (ko) 1999-05-11 2007-08-08 미쯔비시 가가꾸 가부시끼가이샤 퓨린 유도체 이수화물, 이를 유효성분으로 함유하는 의약및 이의 제조 중간체
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
EP1565462A1 (en) * 2002-11-21 2005-08-24 Ranbaxy Laboratories, Ltd. Monohydrate solvates of loracarbef

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
ZA887409B (en) * 1987-10-06 1990-06-27 Lilly Co Eli Crystalline beta-lactam hydrate
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate

Also Published As

Publication number Publication date
IL117228A (en) 2000-12-06
KR19980702666A (ko) 1998-08-05
EP0729959A1 (en) 1996-09-04
AR002709A1 (es) 1998-04-29
DE69603995D1 (de) 1999-10-07
DE69603995T2 (de) 2000-01-20
ZA961341B (en) 1997-08-20
CA2213812A1 (en) 1996-09-06
CZ272897A3 (cs) 1998-01-14
AU5174296A (en) 1996-09-18
TW330205B (en) 1998-04-21
DK0729959T3 (da) 1999-12-13
SI0729959T1 (en) 1999-12-31
HUP9702151A3 (en) 2001-01-29
US5580977A (en) 1996-12-03
AU694639B2 (en) 1998-07-23
IL117228A0 (en) 1996-06-18
GR3031947T3 (en) 2000-03-31
NO973835D0 (no) 1997-08-20
WO1996026942A1 (en) 1996-09-06
NO308471B1 (no) 2000-09-18
ES2135165T3 (es) 1999-10-16
EP0729959B1 (en) 1999-09-01
NO973835L (no) 1997-08-20
PE28097A1 (es) 1997-08-20
ATE184006T1 (de) 1999-09-15
CN1061349C (zh) 2001-01-31
BR9607308A (pt) 1997-11-25
RU2160261C2 (ru) 2000-12-10
JPH11501032A (ja) 1999-01-26
NZ304534A (en) 1998-09-24
CO4700429A1 (es) 1998-12-29
MX9706606A (es) 1997-11-29
CN1182429A (zh) 1998-05-20
PL322111A1 (en) 1998-01-05
TR199700877T1 (xx) 1998-02-21

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