PE28097A1 - Procedimiento para preparar monohidrato de loracarbef - Google Patents

Procedimiento para preparar monohidrato de loracarbef

Info

Publication number
PE28097A1
PE28097A1 PE1996000129A PE00012996A PE28097A1 PE 28097 A1 PE28097 A1 PE 28097A1 PE 1996000129 A PE1996000129 A PE 1996000129A PE 00012996 A PE00012996 A PE 00012996A PE 28097 A1 PE28097 A1 PE 28097A1
Authority
PE
Peru
Prior art keywords
procedure
prepare
give
drying
equal
Prior art date
Application number
PE1996000129A
Other languages
English (en)
Inventor
William Carl Henning
Theodore R Stout
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE28097A1 publication Critical patent/PE28097A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE AL PROCEDIMENTO PARA PREPARAR UNA FORMA CRISTALINA MONOHIDRATADA DE LORACARBEF DE FORMULA I, QUE COMPRENDE: A)SECAR LA FORMA CRISTALINA DE ISOPROPANOLATO DEL COMPUESTO DE FORMULA I DE 50�C A 100�C, PARA DAR UNA FORMA ANHIDRA; B)EXPONERLA A HUMEDAD RELATIVA DE 90% A 100%, PARA DAR UNA FORMA MONOHIDRATADA, CON UN CONTENIDO DE AGUA MAYOR O IGUAL A 10%; C) SECARLA DE 55�C A 75�C Y 20 mbar; OBTENIENDOSE UN MONOHIDRATO CON UNA DENSIDAD APARENTE MAYOR O IGUAL A 0.5 g/ml Y CON UN CONTENIDO DE ISOPROPANOLOL RESIDUAL MENOR A 1% (EN PESO), LO CUAL DISMINUYE EL SOLVENTE AL NIVEL ACEPTADO EN SERES HUMANOS, ELEVA LA DENSIDAD APARENTE Y EVITA LA REHIDRATACION, MEJORANDO SU CAPACIDAD DE FORMULACION
PE1996000129A 1995-03-01 1996-02-26 Procedimiento para preparar monohidrato de loracarbef PE28097A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/396,948 US5580977A (en) 1995-03-01 1995-03-01 Process for preparing loracarbef monohydrate

Publications (1)

Publication Number Publication Date
PE28097A1 true PE28097A1 (es) 1997-08-20

Family

ID=23569249

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000129A PE28097A1 (es) 1995-03-01 1996-02-26 Procedimiento para preparar monohidrato de loracarbef

Country Status (28)

Country Link
US (1) US5580977A (es)
EP (1) EP0729959B1 (es)
JP (1) JPH11501032A (es)
KR (1) KR19980702666A (es)
CN (1) CN1061349C (es)
AR (1) AR002709A1 (es)
AT (1) ATE184006T1 (es)
AU (1) AU694639B2 (es)
BR (1) BR9607308A (es)
CA (1) CA2213812A1 (es)
CO (1) CO4700429A1 (es)
CZ (1) CZ272897A3 (es)
DE (1) DE69603995T2 (es)
DK (1) DK0729959T3 (es)
ES (1) ES2135165T3 (es)
GR (1) GR3031947T3 (es)
HU (1) HUP9702151A3 (es)
IL (1) IL117228A (es)
NO (1) NO308471B1 (es)
NZ (1) NZ304534A (es)
PE (1) PE28097A1 (es)
PL (1) PL322111A1 (es)
RU (1) RU2160261C2 (es)
SI (1) SI0729959T1 (es)
TR (1) TR199700877T1 (es)
TW (1) TW330205B (es)
WO (1) WO1996026942A1 (es)
ZA (1) ZA961341B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100540046B1 (ko) 1997-11-12 2006-01-10 미쓰비시 가가꾸 가부시키가이샤 퓨린유도체 및 이를 유효성분으로 함유하는 의약
JP3956188B2 (ja) 1999-05-11 2007-08-08 三菱化学株式会社 プリン誘導体２水和物、それを有効成分として含む医薬およびその製造中間体
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US20060205938A1 (en) * 2002-11-21 2006-09-14 Yatendra Kumar Monohydrate solvates of loracarbef

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
ZA887409B (en) * 1987-10-06 1990-06-27 Lilly Co Eli Crystalline beta-lactam hydrate
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate

Also Published As

Publication number Publication date
SI0729959T1 (en) 1999-12-31
AU694639B2 (en) 1998-07-23
DE69603995T2 (de) 2000-01-20
CN1061349C (zh) 2001-01-31
CA2213812A1 (en) 1996-09-06
HUP9702151A3 (en) 2001-01-29
GR3031947T3 (en) 2000-03-31
AU5174296A (en) 1996-09-18
NO973835D0 (no) 1997-08-20
BR9607308A (pt) 1997-11-25
NO973835L (no) 1997-08-20
KR19980702666A (ko) 1998-08-05
EP0729959B1 (en) 1999-09-01
PL322111A1 (en) 1998-01-05
TW330205B (en) 1998-04-21
ATE184006T1 (de) 1999-09-15
US5580977A (en) 1996-12-03
JPH11501032A (ja) 1999-01-26
NO308471B1 (no) 2000-09-18
DE69603995D1 (de) 1999-10-07
IL117228A0 (en) 1996-06-18
EP0729959A1 (en) 1996-09-04
MX9706606A (es) 1997-11-29
TR199700877T1 (xx) 1998-02-21
CN1182429A (zh) 1998-05-20
IL117228A (en) 2000-12-06
HUP9702151A2 (hu) 1998-07-28
WO1996026942A1 (en) 1996-09-06
NZ304534A (en) 1998-09-24
CO4700429A1 (es) 1998-12-29
CZ272897A3 (cs) 1998-01-14
ZA961341B (en) 1997-08-20
AR002709A1 (es) 1998-04-29
ES2135165T3 (es) 1999-10-16
RU2160261C2 (ru) 2000-12-10
DK0729959T3 (da) 1999-12-13

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