KR870000294A - 피롤리돈 유도체의 제조방법 - Google Patents

피롤리돈 유도체의 제조방법 Download PDF

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Publication number
KR870000294A
KR870000294A KR1019860004920A KR860004920A KR870000294A KR 870000294 A KR870000294 A KR 870000294A KR 1019860004920 A KR1019860004920 A KR 1019860004920A KR 860004920 A KR860004920 A KR 860004920A KR 870000294 A KR870000294 A KR 870000294A
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South Korea
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alkyl
branched
formula
hydrogen
compound
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KR1019860004920A
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KR930006766B1 (ko
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핀자 마리오
프페이페르 우고
파리나 카르로
파리나 카트로
반피 실바노
Original Assignee
아이.에스.에프. 에스.피.에이
죤 하이드
아이. 에스. 에프. 에스. 피. 에이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음.

Description

피롤리돈 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 구조식(2)화합물을 물과 반응시키고 그 생성물을 분자내 고리화하거나 또는 구조식(6)화합물을 글리신아미드 또는 그것의 전구체와 반응시키며 필요하다면 X가 글리신아미드의 전구체인 생성물을 X가 NHCH₂CONR¹R²임 화합물로 전환시키는 것을 특징으로 하는 하기 구조식(1)화합물의 제조방법.
    상기식들에서
    R₁은 수소 또는 C1-4알킬(직쇄 또는 측쇄)이며
    R²는 수소 또는 C1-4알킬(직쇄 또는 측쇄)이며
    R³와 R⁴는 서로 관련없이 수소, C1-4알킬(직쇄 또는 측쇄), 페닐, 또는 R³와 R⁴가 함께 1, 4-부틸렌(-CH₂)₄-)또는 1, 5-펜틸렌(-(CH₂) -)이며
    R5.1-4알킬(직쇄 또는 측쇄)이며
    X는 아민기로 치환될 수 있는 이탈기임.
  2. 제1항에 있어서, 2-메틸프로필 3-카르바모일메틸-베타-하이드록시-2-(1-메틸에틸)-4-옥소-1-이미다조리딘부타노에이트를 물과 반응시키는 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 4-하이드록시-2-옥시-1-피롤리딘 아세트산을 글리신아미드와 반응시키는 것을 특징으로 하는 방법.
  4. 하기 구조식(7)화합물의 제조에 있어서 Y가 수소일때,
    구조식(5) 화합물을 구조식 NHR¹R²의 아민과 반응시키거나 또는 H가 R⁴O₂CCH₂CH-CH₂-일때, 구조식(3) 화합물을 구조식(4) 화합물과 반응시키는 것을 특징으로 하는 제조방법.
    상기식들에서
    Y는 H 또는-R5는 C1-5알킬(직쇄 또는 측쇄),
    R¹은 수소 또는 C1-4알킬(직쇄 또는 측쇄),
    R²는 수소 또는 C1-4알킬(직쇄 또는 측쇄),
    R³와 R⁴은 서로 관련없이 수소, C1-4알킬(직쇄 또는 측쇄), 페닐, 또는 R³와 R⁴가 함께 1, 4-부틸렌(-(CH₂)₄-또는 1, 5-펜틸렌(-(CH₂) -임.
  5. 약학적 허용 담체 또는 희석제와 함께 제1항의 구조식(1) 화합물을 혼합시키는 것을 특징으로 하는 약학조성물의 제조방법.
  6. 제5항에 있어서, 제1항의 화합물이 2-(4-하이드록시-2-옥소-1-피롤리딘아세트 아미드)아세테이트인것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860004920A 1985-06-21 1986-06-20 피롤리돈 유도체의 제조방법 KR930006766B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21234A/85 1985-06-21
IT21234/85A IT1190378B (it) 1985-06-21 1985-06-21 Derivati pirrolidonici

Publications (2)

Publication Number Publication Date
KR870000294A true KR870000294A (ko) 1987-02-17
KR930006766B1 KR930006766B1 (ko) 1993-07-23

Family

ID=11178795

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004920A KR930006766B1 (ko) 1985-06-21 1986-06-20 피롤리돈 유도체의 제조방법

Country Status (20)

Country Link
US (1) US4824861A (ko)
EP (1) EP0207681B1 (ko)
JP (1) JPS62461A (ko)
KR (1) KR930006766B1 (ko)
AT (1) ATE73821T1 (ko)
AU (1) AU587258B2 (ko)
CA (1) CA1284248C (ko)
DE (1) DE3684368D1 (ko)
DK (1) DK290286A (ko)
ES (2) ES8800164A1 (ko)
FI (1) FI82446C (ko)
GR (1) GR861577B (ko)
HU (1) HU196225B (ko)
IL (1) IL79136A (ko)
IT (1) IT1190378B (ko)
NO (1) NO168428C (ko)
NZ (1) NZ216550A (ko)
PH (1) PH22851A (ko)
PT (2) PT82813B (ko)
ZA (1) ZA864444B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209644B (it) * 1985-06-21 1989-08-30 Isf Spa Composti farmacologicamente attivi.
DK356288A (da) * 1987-07-30 1989-01-31 Lonza Ag Fremgangsmaade til fremstilling af n-((4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl)-glycinamid
NZ232112A (en) * 1989-01-17 1992-07-28 Hoffmann La Roche ((5-oxo-2-pyrrolidinyl)methyl)cyclohexaneacetamides, intermediates therefor and pharmaceutical compositions
CH680293A5 (ko) * 1990-06-26 1992-07-31 Lonza Ag
US6229011B1 (en) * 1997-08-22 2001-05-08 Hoffman-La Roche Inc. N-aroylphenylalanine derivative VCAM-1 inhibitors
KR100649819B1 (ko) 1999-02-18 2007-02-28 에프. 호프만-라 로슈 아게 티오아미드 유도체
RU2238265C2 (ru) 1999-02-18 2004-10-20 Ф.Хоффманн-Ля Рош Аг Фенилаланиноловые производные
WO2009145839A1 (en) * 2008-04-04 2009-12-03 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polyamine compounds that bind tar rna of hiv and methods of treating viral disorders
CN101914052B (zh) * 2010-08-02 2012-06-27 胡建荣 一种奥拉西坦化合物的制备方法
CN102351770B (zh) * 2011-08-12 2012-07-04 江西新先锋医药有限公司 一种奥拉西坦化合物及其药物组合物
CN112724062B (zh) * 2021-01-19 2022-03-15 江苏诚信药业有限公司 一种奥拉西坦杂质b的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH449029A (de) * 1963-08-12 1967-12-31 Hoffmann La Roche Verfahren zur Herstellung von 4-Imidazolidon-Verbindungen
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
AT360980B (de) * 1976-01-14 1981-02-10 Pliva Pharm & Chem Works Verfahren zur herstellung von n-alkylamiden des 2-oxo-1-pyrrolidins
YU39660B (en) * 1976-01-14 1985-03-20 Pliva Pharm & Chem Works Process for obtaining 2-oxo-1-pyrrolidine acetamide
GB1539817A (en) * 1976-10-22 1979-02-07 Ucb Sa N-substituted lactams
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
FI840261A (fi) * 1983-01-27 1984-07-28 Ciba Geigy Ag Substituerade pyrrolidinonderivat och foerfarande foer deras framstaellning.
IT1209644B (it) * 1985-06-21 1989-08-30 Isf Spa Composti farmacologicamente attivi.
JPH0681502B2 (ja) * 1988-07-14 1994-10-12 富士通電装株式会社 並列運転保護回路

Also Published As

Publication number Publication date
FI862420A0 (fi) 1986-06-06
ZA864444B (en) 1987-02-25
ATE73821T1 (de) 1992-04-15
NO862486D0 (no) 1986-06-20
FI862420A (fi) 1986-12-22
NO862486L (no) 1986-12-22
ES8800164A1 (es) 1987-11-01
DK290286D0 (da) 1986-06-20
PH22851A (en) 1989-01-19
PT82813A (en) 1986-07-01
NZ216550A (en) 1990-02-26
PT82813B (pt) 1988-04-21
EP0207681A2 (en) 1987-01-07
PT82815A (en) 1986-07-01
NO168428C (no) 1992-02-19
ES556353A0 (es) 1987-11-01
HUT43815A (en) 1987-12-28
JPS62461A (ja) 1987-01-06
US4824861A (en) 1989-04-25
FI82446C (fi) 1991-03-11
NO168428B (no) 1991-11-11
DE3684368D1 (de) 1992-04-23
IT1190378B (it) 1988-02-16
DK290286A (da) 1986-12-22
EP0207681A3 (en) 1988-06-01
ES556351A0 (es) 1988-01-01
CA1284248C (en) 1991-05-14
IT8521234A0 (it) 1985-06-21
AU587258B2 (en) 1989-08-10
GR861577B (en) 1986-10-21
ES8801201A1 (es) 1988-01-01
IL79136A (en) 1991-07-18
AU5891986A (en) 1986-12-24
FI82446B (fi) 1990-11-30
HU196225B (en) 1988-10-28
PT82815B (pt) 1988-04-21
IL79136A0 (en) 1986-09-30
EP0207681B1 (en) 1992-03-18
KR930006766B1 (ko) 1993-07-23

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