IT1190378B - Derivati pirrolidonici - Google Patents
Derivati pirrolidoniciInfo
- Publication number
- IT1190378B IT1190378B IT21234/85A IT2123485A IT1190378B IT 1190378 B IT1190378 B IT 1190378B IT 21234/85 A IT21234/85 A IT 21234/85A IT 2123485 A IT2123485 A IT 2123485A IT 1190378 B IT1190378 B IT 1190378B
- Authority
- IT
- Italy
- Prior art keywords
- pyrolidonic
- derivatives
- branched
- alkyl
- hydrogen
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002664 nootropic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21234/85A IT1190378B (it) | 1985-06-21 | 1985-06-21 | Derivati pirrolidonici |
| FI862420A FI82446C (fi) | 1985-06-21 | 1986-06-06 | Foerfarande foer framstaellning av farmakologiskt vaerdefulla pyrrolidinoderivat. |
| ZA864444A ZA864444B (en) | 1985-06-21 | 1986-06-13 | Pyrrolidone derivatives |
| NZ216550A NZ216550A (en) | 1985-06-21 | 1986-06-16 | Pyrrolidone derivatives and pharmaceutical compositions |
| EP86304653A EP0207681B1 (en) | 1985-06-21 | 1986-06-17 | Pyrrolidone derivatives |
| AT86304653T ATE73821T1 (de) | 1985-06-21 | 1986-06-17 | Pyrrolidonderivate. |
| IL79136A IL79136A (en) | 1985-06-21 | 1986-06-17 | 2-(4-hydroxy-2-oxo-1-pyrrolidine)acetamido acetamides,process for their preparation and pharmaceutical compositions comprising them |
| DE8686304653T DE3684368D1 (de) | 1985-06-21 | 1986-06-17 | Pyrrolidonderivate. |
| GR861577A GR861577B (en) | 1985-06-21 | 1986-06-18 | Pyrrolidone derivatives and process for their preparation |
| JP61144686A JPS62461A (ja) | 1985-06-21 | 1986-06-20 | ピロリドン誘導体及びその製造方法 |
| CA000512114A CA1284248C (en) | 1985-06-21 | 1986-06-20 | Pyrrolidone derivatives |
| PT82815A PT82815B (pt) | 1985-06-21 | 1986-06-20 | Processo de preparacao de derivados da imidazolidina, dos seus sais farmaceuticamente aceitaveis e das composicoes farmaceuticas que os contem |
| HU862609A HU196225B (en) | 1985-06-21 | 1986-06-20 | Process for producing new pirrolidine derivatives and pharmaceutical compositions containing the new compounds |
| NO862486A NO168428C (no) | 1985-06-21 | 1986-06-20 | Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt pyrrolidonderivat |
| ES556351A ES8801201A1 (es) | 1985-06-21 | 1986-06-20 | Un procedimiento para preparar derivados de pirrolidona |
| AU58919/86A AU587258B2 (en) | 1985-06-21 | 1986-06-20 | N-substituted-4-hydroxy-2-oxopyrrolidine derivatives |
| PH33922A PH22851A (en) | 1985-06-21 | 1986-06-20 | Pyrrolidone derivatives |
| ES556353A ES8800164A1 (es) | 1985-06-21 | 1986-06-20 | Un procedimiento para preparar derivados de imidazolidina |
| PT82813A PT82813B (pt) | 1985-06-21 | 1986-06-20 | Processo de preparacao de derivados da pirrolidona, dos seus intermediarios e de composicoes farmaceuticas |
| KR1019860004920A KR930006766B1 (ko) | 1985-06-21 | 1986-06-20 | 피롤리돈 유도체의 제조방법 |
| DK290286A DK290286A (da) | 1985-06-21 | 1986-06-20 | Imidazolidinforbindelse og fremgangsmaade til fremstilling deraf |
| US07/131,862 US4824861A (en) | 1985-06-21 | 1987-12-11 | Pyrrolidone derivatives and memory enhancement use thereof |
| US07/300,526 US4868313A (en) | 1985-06-21 | 1989-01-23 | A process for making pyrrolidone derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21234/85A IT1190378B (it) | 1985-06-21 | 1985-06-21 | Derivati pirrolidonici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8521234A0 IT8521234A0 (it) | 1985-06-21 |
| IT1190378B true IT1190378B (it) | 1988-02-16 |
Family
ID=11178795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21234/85A IT1190378B (it) | 1985-06-21 | 1985-06-21 | Derivati pirrolidonici |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4824861A (it) |
| EP (1) | EP0207681B1 (it) |
| JP (1) | JPS62461A (it) |
| KR (1) | KR930006766B1 (it) |
| AT (1) | ATE73821T1 (it) |
| AU (1) | AU587258B2 (it) |
| CA (1) | CA1284248C (it) |
| DE (1) | DE3684368D1 (it) |
| DK (1) | DK290286A (it) |
| ES (2) | ES8800164A1 (it) |
| FI (1) | FI82446C (it) |
| GR (1) | GR861577B (it) |
| HU (1) | HU196225B (it) |
| IL (1) | IL79136A (it) |
| IT (1) | IT1190378B (it) |
| NO (1) | NO168428C (it) |
| NZ (1) | NZ216550A (it) |
| PH (1) | PH22851A (it) |
| PT (2) | PT82815B (it) |
| ZA (1) | ZA864444B (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| DK356288A (da) * | 1987-07-30 | 1989-01-31 | Lonza Ag | Fremgangsmaade til fremstilling af n-((4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl)-glycinamid |
| CA2007732A1 (en) * | 1989-01-17 | 1990-07-17 | Gary L. Olson | Cyclohexaneacetamide derivatives |
| CH680293A5 (it) * | 1990-06-26 | 1992-07-31 | Lonza Ag | |
| US6229011B1 (en) * | 1997-08-22 | 2001-05-08 | Hoffman-La Roche Inc. | N-aroylphenylalanine derivative VCAM-1 inhibitors |
| ES2228458T3 (es) | 1999-02-18 | 2005-04-16 | F. Hoffmann-La Roche Ag | Derivados de tioamida. |
| ATE264835T1 (de) | 1999-02-18 | 2004-05-15 | Hoffmann La Roche | Phenylalaninolderivate |
| WO2009145839A1 (en) * | 2008-04-04 | 2009-12-03 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polyamine compounds that bind tar rna of hiv and methods of treating viral disorders |
| CN101914052B (zh) * | 2010-08-02 | 2012-06-27 | 胡建荣 | 一种奥拉西坦化合物的制备方法 |
| CN102351770B (zh) * | 2011-08-12 | 2012-07-04 | 江西新先锋医药有限公司 | 一种奥拉西坦化合物及其药物组合物 |
| CN112724062B (zh) * | 2021-01-19 | 2022-03-15 | 江苏诚信药业有限公司 | 一种奥拉西坦杂质b的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH470396A (de) * | 1963-08-12 | 1969-03-31 | Hoffmann La Roche | Verfahren zur Herstellung von 4-Imidazolidon-Verbindungen |
| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| AT360980B (de) * | 1976-01-14 | 1981-02-10 | Pliva Pharm & Chem Works | Verfahren zur herstellung von n-alkylamiden des 2-oxo-1-pyrrolidins |
| YU39660B (en) * | 1976-01-14 | 1985-03-20 | Pliva Pharm & Chem Works | Process for obtaining 2-oxo-1-pyrrolidine acetamide |
| GB1539817A (en) * | 1976-10-22 | 1979-02-07 | Ucb Sa | N-substituted lactams |
| IT1075564B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
| IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
| FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| FI840261A7 (fi) * | 1983-01-27 | 1984-07-28 | Ciba Geigy Ag | Substituerade pyrrolidinonderivat och foerfarande foer deras framstaellning. |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| JPH0681502B2 (ja) * | 1988-07-14 | 1994-10-12 | 富士通電装株式会社 | 並列運転保護回路 |
-
1985
- 1985-06-21 IT IT21234/85A patent/IT1190378B/it active
-
1986
- 1986-06-06 FI FI862420A patent/FI82446C/fi not_active IP Right Cessation
- 1986-06-13 ZA ZA864444A patent/ZA864444B/xx unknown
- 1986-06-16 NZ NZ216550A patent/NZ216550A/xx unknown
- 1986-06-17 EP EP86304653A patent/EP0207681B1/en not_active Expired - Lifetime
- 1986-06-17 AT AT86304653T patent/ATE73821T1/de not_active IP Right Cessation
- 1986-06-17 IL IL79136A patent/IL79136A/xx unknown
- 1986-06-17 DE DE8686304653T patent/DE3684368D1/de not_active Expired - Lifetime
- 1986-06-18 GR GR861577A patent/GR861577B/el unknown
- 1986-06-20 JP JP61144686A patent/JPS62461A/ja active Pending
- 1986-06-20 PH PH33922A patent/PH22851A/en unknown
- 1986-06-20 ES ES556353A patent/ES8800164A1/es not_active Expired
- 1986-06-20 HU HU862609A patent/HU196225B/hu not_active IP Right Cessation
- 1986-06-20 PT PT82815A patent/PT82815B/pt not_active IP Right Cessation
- 1986-06-20 CA CA000512114A patent/CA1284248C/en not_active Expired - Fee Related
- 1986-06-20 DK DK290286A patent/DK290286A/da not_active Application Discontinuation
- 1986-06-20 NO NO862486A patent/NO168428C/no unknown
- 1986-06-20 KR KR1019860004920A patent/KR930006766B1/ko not_active Expired - Lifetime
- 1986-06-20 PT PT82813A patent/PT82813B/pt not_active IP Right Cessation
- 1986-06-20 AU AU58919/86A patent/AU587258B2/en not_active Ceased
- 1986-06-20 ES ES556351A patent/ES8801201A1/es not_active Expired
-
1987
- 1987-12-11 US US07/131,862 patent/US4824861A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950630 |