ATE191932T1 - Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor - Google Patents
Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitorInfo
- Publication number
- ATE191932T1 ATE191932T1 AT96101581T AT96101581T ATE191932T1 AT E191932 T1 ATE191932 T1 AT E191932T1 AT 96101581 T AT96101581 T AT 96101581T AT 96101581 T AT96101581 T AT 96101581T AT E191932 T1 ATE191932 T1 AT E191932T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- enzymin
- hibitor
- lactam antibiotics
- enzymatic synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002132 β-lactam antibiotic Substances 0.000 title 1
- 229940124586 β-lactam antibiotics Drugs 0.000 title 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 108010073038 Penicillin Amidase Proteins 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/10—Modification of an amino radical directly attached in position 6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/84—Penicillin amidase (3.5.1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI950383A IT1274658B (it) | 1995-02-28 | 1995-02-28 | Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine |
| ITMI960033 IT1282362B1 (it) | 1996-01-11 | 1996-01-11 | Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE191932T1 true ATE191932T1 (de) | 2000-05-15 |
Family
ID=26331248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96101581T ATE191932T1 (de) | 1995-02-28 | 1996-02-05 | Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0730036B1 (de) |
| JP (1) | JPH08256789A (de) |
| KR (1) | KR100449193B1 (de) |
| CN (1) | CN1087350C (de) |
| AT (1) | ATE191932T1 (de) |
| AU (1) | AU699930B2 (de) |
| BR (1) | BR9600835A (de) |
| CA (1) | CA2168923C (de) |
| DE (1) | DE69607778T2 (de) |
| DK (1) | DK0730036T3 (de) |
| ES (1) | ES2146332T3 (de) |
| GR (1) | GR3033900T3 (de) |
| PT (1) | PT730036E (de) |
| RU (1) | RU2002109387A (de) |
| UA (1) | UA44709C2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998056944A1 (en) * | 1997-06-10 | 1998-12-17 | Dsm N.V. | APPLICATION OF REDUCING SULPHUR COMPOUNDS DURING ENZYMATIC PREPARATION OF β-LACTAM COMPOUNDS |
| WO1998056945A1 (en) * | 1997-06-10 | 1998-12-17 | Dsm N.V. | PROCESS FOR ENZYMATICALLY PREPARING A β-LACTAM ANTIBIOTIC AND THIS ANTIBIOTIC |
| CN1080760C (zh) * | 1997-12-12 | 2002-03-13 | 中国科学院上海生物化学研究所 | 戊二酰－7－氨基头孢烷酸酰化酶 |
| NL1010506C2 (nl) * | 1998-11-06 | 2000-05-09 | Dsm Nv | Werkwijze voor de bereiding van bêta-lactam antibiotica. |
| CN100368554C (zh) * | 2005-04-26 | 2008-02-13 | 华南理工大学 | 酶催化“一锅法”制备β-内酰胺抗生素的方法 |
| CN106632399B (zh) * | 2016-09-27 | 2018-10-02 | 盐城开元医药化工有限公司 | 一种头孢沙定母核的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5231436B2 (de) * | 1971-08-20 | 1977-08-15 | ||
| ES2036149A6 (es) * | 1989-12-12 | 1993-05-01 | Consejo Superior Investigacion | Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa. |
| CA2086250C (en) * | 1990-07-04 | 2001-05-29 | Svend Gunnar Kaasgaard | Process for preparation of beta-lactams |
| DE618979T1 (de) * | 1991-12-19 | 1995-05-18 | Novonordisk As | Verbesserte methode zur herstellung von bestimmten -g(b)-lactam-antibiotika. |
| WO1995034675A1 (en) * | 1994-06-10 | 1995-12-21 | Gist-Brocades B.V. | Improved acylation method for penicillins and cephalosporins |
-
1996
- 1996-02-05 ES ES96101581T patent/ES2146332T3/es not_active Expired - Lifetime
- 1996-02-05 DE DE69607778T patent/DE69607778T2/de not_active Expired - Lifetime
- 1996-02-05 DK DK96101581T patent/DK0730036T3/da active
- 1996-02-05 AT AT96101581T patent/ATE191932T1/de active
- 1996-02-05 EP EP96101581A patent/EP0730036B1/de not_active Expired - Lifetime
- 1996-02-05 PT PT96101581T patent/PT730036E/pt unknown
- 1996-02-06 CA CA002168923A patent/CA2168923C/en not_active Expired - Lifetime
- 1996-02-23 JP JP8036837A patent/JPH08256789A/ja active Pending
- 1996-02-27 CN CN96102555A patent/CN1087350C/zh not_active Expired - Lifetime
- 1996-02-27 UA UA96020754A patent/UA44709C2/uk unknown
- 1996-02-27 KR KR1019960004720A patent/KR100449193B1/ko not_active Expired - Fee Related
- 1996-02-28 AU AU45799/96A patent/AU699930B2/en not_active Expired
- 1996-02-28 BR BR9600835A patent/BR9600835A/pt not_active Application Discontinuation
-
2000
- 2000-07-05 GR GR20000401585T patent/GR3033900T3/el unknown
-
2002
- 2002-04-10 RU RU2002109387/13A patent/RU2002109387A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UA44709C2 (uk) | 2002-03-15 |
| CA2168923A1 (en) | 1996-08-29 |
| AU4579996A (en) | 1996-09-05 |
| KR960031463A (ko) | 1996-09-17 |
| CN1087350C (zh) | 2002-07-10 |
| CN1137568A (zh) | 1996-12-11 |
| AU699930B2 (en) | 1998-12-17 |
| EP0730036A1 (de) | 1996-09-04 |
| KR100449193B1 (ko) | 2005-08-17 |
| GR3033900T3 (en) | 2000-11-30 |
| DK0730036T3 (da) | 2000-07-24 |
| EP0730036B1 (de) | 2000-04-19 |
| JPH08256789A (ja) | 1996-10-08 |
| ES2146332T3 (es) | 2000-08-01 |
| RU2002109387A (ru) | 2003-10-20 |
| BR9600835A (pt) | 1997-12-30 |
| DE69607778T2 (de) | 2000-08-10 |
| CA2168923C (en) | 2009-09-15 |
| PT730036E (pt) | 2000-07-31 |
| DE69607778D1 (de) | 2000-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |