IT1282362B1 - Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima - Google Patents
Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzimaInfo
- Publication number
- IT1282362B1 IT1282362B1 ITMI960033A IT1282362B1 IT 1282362 B1 IT1282362 B1 IT 1282362B1 IT MI960033 A ITMI960033 A IT MI960033A IT 1282362 B1 IT1282362 B1 IT 1282362B1
- Authority
- IT
- Italy
- Prior art keywords
- formula
- sic
- halogen
- reaction
- enzyme inhibitor
- Prior art date
Links
- 229940125532 enzyme inhibitor Drugs 0.000 title abstract 2
- 239000002532 enzyme inhibitor Substances 0.000 title abstract 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002132 β-lactam antibiotic Substances 0.000 title 1
- 229940124586 β-lactam antibiotics Drugs 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 108010073038 Penicillin Amidase Proteins 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000033 IT1282362B1 (it) | 1996-01-11 | 1996-01-11 | Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima |
| PT96101581T PT730036E (pt) | 1995-02-28 | 1996-02-05 | Processo para a sintese enzimatica de antibioticos beta-lactamicos na presenca de um inibidor da enzima |
| DE69607778T DE69607778T2 (de) | 1995-02-28 | 1996-02-05 | Verfahren zur enzymatischen Synthese von beta-laktam Antibiotika in Anwesenheit von einem Enzyminhibitor |
| EP96101581A EP0730036B1 (en) | 1995-02-28 | 1996-02-05 | Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor |
| AT96101581T ATE191932T1 (de) | 1995-02-28 | 1996-02-05 | Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor |
| ES96101581T ES2146332T3 (es) | 1995-02-28 | 1996-02-05 | Procedimiento para la sintesis enzimatica de antibioticos beta-lactama en presencia de un inhibidor de enzima. |
| DK96101581T DK0730036T3 (da) | 1995-02-28 | 1996-02-05 | Fremgangsmåde til enzymatisk syntese af Beta-lactamantibiotika i nærvær af en enzyminhibitor |
| CA002168923A CA2168923C (en) | 1995-02-28 | 1996-02-06 | Process for the enzymatic synthesis of .beta.-lactam antibiotics in the presence of an enzyme inhibitor |
| JP8036837A JPH08256789A (ja) | 1995-02-28 | 1996-02-23 | β−ラクタム抗生物質の酵素阻害剤の存在下での酵素合成法 |
| CN96102555A CN1087350C (zh) | 1995-02-28 | 1996-02-27 | 酶抑制剂存在下酶法合成β－内酰胺抗生素的方法 |
| KR1019960004720A KR100449193B1 (ko) | 1995-02-28 | 1996-02-27 | 효소억제제의존재하에서의β-락탐항생제의효소적합성방법 |
| UA96020754A UA44709C2 (uk) | 1995-02-28 | 1996-02-27 | Спосіб oдержання пеніциліну чи цефалоспорину |
| AU45799/96A AU699930B2 (en) | 1995-02-28 | 1996-02-28 | Process for enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor |
| BR9600835A BR9600835A (pt) | 1995-02-28 | 1996-02-28 | Processo para preparar penicilinas ou cefalosporinas e composiç o farmacêutica que as contêm |
| GR20000401585T GR3033900T3 (en) | 1995-02-28 | 2000-07-05 | Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor |
| RU2002109387/13A RU2002109387A (ru) | 1995-02-28 | 2002-04-10 | Способ ферментативного синтеза бета-лактамовых антибиотиков в присутствии ингибитора фермента |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000033 IT1282362B1 (it) | 1996-01-11 | 1996-01-11 | Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI960033A0 ITMI960033A0 (it) | 1996-01-11 |
| ITMI960033A1 ITMI960033A1 (it) | 1997-07-11 |
| IT1282362B1 true IT1282362B1 (it) | 1998-03-20 |
Family
ID=11372877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT96MI000033 IT1282362B1 (it) | 1995-02-28 | 1996-01-11 | Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1282362B1 (it) |
-
1996
- 1996-01-11 IT IT96MI000033 patent/IT1282362B1/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI960033A0 (it) | 1996-01-11 |
| ITMI960033A1 (it) | 1997-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |