KR880000448A - 세팔로스포린 유도체의 제조방법 - Google Patents
세팔로스포린 유도체의 제조방법 Download PDFInfo
- Publication number
- KR880000448A KR880000448A KR1019860005101A KR860005101A KR880000448A KR 880000448 A KR880000448 A KR 880000448A KR 1019860005101 A KR1019860005101 A KR 1019860005101A KR 860005101 A KR860005101 A KR 860005101A KR 880000448 A KR880000448 A KR 880000448A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- alkyl
- compound
- following formula
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 하기 일반식(Ⅱ)의 화합물을 하기 일반식(Ⅲ)의 화합물과 반응시켜 얻어진 반응성 유도체를 하기 일반식 (Ⅳ)의 화합물과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 Syn이성체를 제조하는 방법.식중, R은 푸릴기, 티아졸릴기, 티아디졸릴기를 나타내며 R1은 6 개 이하의 탄소원자를 갖는 알킬, 알케닐, 알키닐 또는 시클로알킬기들을 나타낸다. Z은 수소 또는 할로겐 원자이거나 5 개 이하의 탄소원자를 갖는 알킬, 시클로알킬, 알콕시 또는 알킬티오기, 또는 아세톡시메틸 또는 카르바모일옥시메틸기, 또는 R2가 S 및 N에서 선택된 임의로 치환된 1-4개의 헤테로 원자를 함유하는 5-6개의 고리를 가진 헤테로사이클을 나타내는 경우의-CH2-S-R2기, 혹은 -CH-R2기, 또는나기를 나타내며, R3는 수소 또는 1-5개의 탄소원자를 가진 알킬, 에스테르, 유기산, 또는 아미드기를 나타낸다. M은 수소원자, 알칼리나, 알칼리토금속, 또는 에스테르기를 나타내며 COOM기는 CO2를 나타내기도 하며 Z이를 나타내는 경우 COOM는 C00-를 나타낸다.상기 일반식(Ⅲ)에서 R4는 알킬 또는 아릴기를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019860005101A KR890002107B1 (ko) | 1986-06-25 | 1986-06-25 | 세팔로스포린 유도체의 제조방법 |
JP62155237A JPS6322570A (ja) | 1986-06-25 | 1987-06-22 | 1−メタンスルホニルオキシ−6−トリフルオロメチル−1h−ベンゾトリアゾ−ル及びセファロスポリン誘導体の製造方法 |
DE19873744772 DE3744772A1 (ko) | 1986-06-25 | 1987-06-23 | |
IT21014/87A IT1205178B (it) | 1986-06-25 | 1987-06-23 | 1-metansolfonilossi-6-trifluorometi l-1h-benzotriazolo e il suo impiego per preparare derivati della cefalosporina |
DE19873720681 DE3720681A1 (de) | 1986-06-25 | 1987-06-23 | 1-methansulfonyloxy- und p-toluolsulfonyloxy-6-trifluormethyl-1h-benzotriazol, 2-heterocyclyl-2-syn-oxyiminoessigsaeure-5-trifluormethyl-1h-benzotriazol-1-yl-ester und deren verwendung zur herstellung von cephalosporinderivaten |
GB08714764A GB2195334A (en) | 1986-06-25 | 1987-06-24 | 1-Methanesulfonyloxy-6-trifluoromethyl-1H-benzotriazole and its use in preparing cephalosporin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019860005101A KR890002107B1 (ko) | 1986-06-25 | 1986-06-25 | 세팔로스포린 유도체의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880000448A true KR880000448A (ko) | 1988-03-25 |
KR890002107B1 KR890002107B1 (ko) | 1989-06-19 |
Family
ID=19250716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860005101A KR890002107B1 (ko) | 1986-06-25 | 1986-06-25 | 세팔로스포린 유도체의 제조방법 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS6322570A (ko) |
KR (1) | KR890002107B1 (ko) |
DE (2) | DE3720681A1 (ko) |
GB (1) | GB2195334A (ko) |
IT (1) | IT1205178B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR890100706A (el) * | 1989-10-31 | 1992-03-20 | Han Mi Pharma Ind Co Ltd | Μέ?οδος παρασκευής παραγώγων κεφέμης. |
AT398764B (de) * | 1992-01-28 | 1995-01-25 | Lek Tovarna Farmacevtskih | Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat |
AT399877B (de) * | 1992-02-20 | 1995-08-25 | Biochemie Gmbh | Neues verfahren zur herstellung von ceftriaxon |
WO1996012712A1 (en) * | 1994-10-24 | 1996-05-02 | Miwon Co., Ltd. | Reactive phosphate derivatives of thiazolylacetic acid and process for preparing cephalosporin antibiotics using the same |
KR100197788B1 (ko) * | 1995-06-30 | 1999-06-15 | 김충환 | 세펨 유도체의 제조방법 |
-
1986
- 1986-06-25 KR KR1019860005101A patent/KR890002107B1/ko not_active IP Right Cessation
-
1987
- 1987-06-22 JP JP62155237A patent/JPS6322570A/ja active Pending
- 1987-06-23 DE DE19873720681 patent/DE3720681A1/de not_active Withdrawn
- 1987-06-23 DE DE19873744772 patent/DE3744772A1/de active Pending
- 1987-06-23 IT IT21014/87A patent/IT1205178B/it active
- 1987-06-24 GB GB08714764A patent/GB2195334A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR890002107B1 (ko) | 1989-06-19 |
IT1205178B (it) | 1989-03-15 |
IT8721014A0 (it) | 1987-06-23 |
DE3744772A1 (ko) | 1989-02-02 |
GB8714764D0 (en) | 1987-07-29 |
JPS6322570A (ja) | 1988-01-30 |
DE3720681A1 (de) | 1988-01-28 |
GB2195334A (en) | 1988-04-07 |
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