AT399877B - Neues verfahren zur herstellung von ceftriaxon - Google Patents
Neues verfahren zur herstellung von ceftriaxonInfo
- Publication number
- AT399877B AT399877B AT0030992A AT30992A AT399877B AT 399877 B AT399877 B AT 399877B AT 0030992 A AT0030992 A AT 0030992A AT 30992 A AT30992 A AT 30992A AT 399877 B AT399877 B AT 399877B
- Authority
- AT
- Austria
- Prior art keywords
- ceftriaxone
- producing
- new method
- methyl
- disodium salt
- Prior art date
Links
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 title abstract 3
- 229960004755 ceftriaxone Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 2
- YTUNICCSPPTMJY-URYLQHRCSA-N (6r)-7-amino-3-[(2-methyl-5,6-dioxo-1h-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound CN1NC(=O)C(=O)N=C1SCC1=C(C(O)=O)N2C(=O)C(N)[C@H]2SC1 YTUNICCSPPTMJY-URYLQHRCSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0030992A AT399877B (de) | 1992-02-20 | 1992-02-20 | Neues verfahren zur herstellung von ceftriaxon |
| SG1996004588A SG47054A1 (en) | 1992-02-20 | 1993-02-16 | New process for the production of ceftriaxone |
| DE69321749T DE69321749T2 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur Herstellung von Ceftriaxon |
| ES93102381T ES2124748T3 (es) | 1992-02-20 | 1993-02-16 | Nuevo proceso para la produccion de ceftriaxona. |
| AT93102381T ATE172734T1 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur herstellung von ceftriaxon |
| EP93102381A EP0556768B1 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur Herstellung von Ceftriaxon |
| US08/019,735 US5574155A (en) | 1992-02-20 | 1993-02-19 | Process for the synthesis of the disodium salt hemiheptahydrate of ceftriaxone |
| JP5030350A JP2609039B2 (ja) | 1992-02-20 | 1993-02-19 | セフトリアキソンの新規製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0030992A AT399877B (de) | 1992-02-20 | 1992-02-20 | Neues verfahren zur herstellung von ceftriaxon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA30992A ATA30992A (de) | 1994-12-15 |
| AT399877B true AT399877B (de) | 1995-08-25 |
Family
ID=3487145
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0030992A AT399877B (de) | 1992-02-20 | 1992-02-20 | Neues verfahren zur herstellung von ceftriaxon |
| AT93102381T ATE172734T1 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur herstellung von ceftriaxon |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93102381T ATE172734T1 (de) | 1992-02-20 | 1993-02-16 | Verfahren zur herstellung von ceftriaxon |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5574155A (de) |
| EP (1) | EP0556768B1 (de) |
| JP (1) | JP2609039B2 (de) |
| AT (2) | AT399877B (de) |
| DE (1) | DE69321749T2 (de) |
| ES (1) | ES2124748T3 (de) |
| SG (1) | SG47054A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT402928B (de) * | 1994-12-23 | 1997-09-25 | Biochemie Gmbh | Neues verfahren zur herstellung von cefotaxim |
| KR100361829B1 (ko) * | 1997-04-16 | 2005-08-17 | 주식회사 엘지생명과학 | 반응성 유기산 유도체로 부터 세프트리악손을 제조하는 방법 |
| EP1169324A1 (de) | 1999-04-15 | 2002-01-09 | BIOCHEMIE Gesellschaft m.b.H. | Beta-lactamherstellung |
| US7847093B2 (en) * | 2003-04-16 | 2010-12-07 | Sandoz Ag | Processes for the preparations of cefepime |
| ES2348299T3 (es) | 2003-04-16 | 2010-12-02 | Sandoz Ag | Procedimientos para la preparación de cefepime. |
| US7098329B2 (en) * | 2003-06-19 | 2006-08-29 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of a cephalosporin antibiotic |
| US20050059820A1 (en) * | 2003-09-17 | 2005-03-17 | Debashish Datta | Method for manufacture of ceftriaxone sodium |
| CN101210020B (zh) * | 2006-12-31 | 2010-11-24 | 山东轩竹医药科技有限公司 | 新型头孢菌素化合物 |
| RU2382790C2 (ru) * | 2007-10-25 | 2010-02-27 | Общество с ограниченной ответственностью "КОМПАНИЯ "ДЕКО" | Способ получения динатриевой соли гемигептагидрата 7-{[2-аминотиазол-4-ил)-2-син-метоксиимино]ацетамидо}-3-{[(2,5-дигидро-6-гидрокси-2-метил-5-оксо-1,2,4-триазин-3-ил)тио]метил}-3-цефем-4-карбоновой кислоты |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1240314A (en) * | 1974-06-21 | 1988-08-09 | Marc Montavon | Acyl derivatives |
| EP0399094A2 (de) * | 1989-05-23 | 1990-11-28 | S.B.D. SYNTHETIC AND BIOLOGICAL DEVELOPMENTS S.r.l. | Verfahren zur Herstellung von Ceftriaxon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| MC1259A1 (fr) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | Derives acyles |
| CH641468A5 (de) * | 1978-05-30 | 1984-02-29 | Hoffmann La Roche | Cephemderivate. |
| FI67385C (fi) * | 1979-11-21 | 1985-03-11 | Hoffmann La Roche | Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat |
| EP0037380B1 (de) * | 1980-03-28 | 1984-09-12 | BIOCHEMIE Gesellschaft m.b.H. | Verfahren zum Herstellen von Cephalosporin-Antibiotika und Zwischenprodukte zur Verwendung in diesem Verfahren und ihre Herstellung |
| KR870001332B1 (ko) * | 1984-09-27 | 1987-07-18 | 한미약품공업 주식회사 | 세펨 유도체의 간단한 제조방법 |
| KR890002107B1 (ko) * | 1986-06-25 | 1989-06-19 | 재단법인 한국화학연구소 | 세팔로스포린 유도체의 제조방법 |
| DE3911322A1 (de) * | 1989-04-07 | 1990-10-11 | Hoechst Ag | Verfahren zur herstellung von cefodizim-dinatrium |
| AT398764B (de) * | 1992-01-28 | 1995-01-25 | Lek Tovarna Farmacevtskih | Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat |
-
1992
- 1992-02-20 AT AT0030992A patent/AT399877B/de not_active IP Right Cessation
-
1993
- 1993-02-16 ES ES93102381T patent/ES2124748T3/es not_active Expired - Lifetime
- 1993-02-16 DE DE69321749T patent/DE69321749T2/de not_active Expired - Lifetime
- 1993-02-16 SG SG1996004588A patent/SG47054A1/en unknown
- 1993-02-16 EP EP93102381A patent/EP0556768B1/de not_active Expired - Lifetime
- 1993-02-16 AT AT93102381T patent/ATE172734T1/de active
- 1993-02-19 JP JP5030350A patent/JP2609039B2/ja not_active Expired - Lifetime
- 1993-02-19 US US08/019,735 patent/US5574155A/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1240314A (en) * | 1974-06-21 | 1988-08-09 | Marc Montavon | Acyl derivatives |
| EP0399094A2 (de) * | 1989-05-23 | 1990-11-28 | S.B.D. SYNTHETIC AND BIOLOGICAL DEVELOPMENTS S.r.l. | Verfahren zur Herstellung von Ceftriaxon |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69321749T2 (de) | 1999-04-22 |
| JPH069648A (ja) | 1994-01-18 |
| EP0556768A2 (de) | 1993-08-25 |
| DE69321749D1 (de) | 1998-12-03 |
| EP0556768A3 (en) | 1993-11-24 |
| SG47054A1 (en) | 1998-03-20 |
| JP2609039B2 (ja) | 1997-05-14 |
| ATE172734T1 (de) | 1998-11-15 |
| ES2124748T3 (es) | 1999-02-16 |
| US5574155A (en) | 1996-11-12 |
| EP0556768B1 (de) | 1998-10-28 |
| ATA30992A (de) | 1994-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |