DE3872956D1 - Verfahren zur herstellung von 2,4-diamino-6-(1-piperidinyl)-pyramidin-n-oxid. - Google Patents
Verfahren zur herstellung von 2,4-diamino-6-(1-piperidinyl)-pyramidin-n-oxid.Info
- Publication number
- DE3872956D1 DE3872956D1 DE8888830189T DE3872956T DE3872956D1 DE 3872956 D1 DE3872956 D1 DE 3872956D1 DE 8888830189 T DE8888830189 T DE 8888830189T DE 3872956 T DE3872956 T DE 3872956T DE 3872956 D1 DE3872956 D1 DE 3872956D1
- Authority
- DE
- Germany
- Prior art keywords
- diamino
- oxide
- piperidinyl
- chem
- pyramidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 2,4-DIAMINO-6- (1-PIPERIDINYL) -PYRAMIDIN-N-OXIDE Chemical compound 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- QJIUMVUZDYPQRT-UHFFFAOYSA-N 6-chloro-2,4-pyrimidinediamine Chemical compound NC1=CC(Cl)=NC(N)=N1 QJIUMVUZDYPQRT-UHFFFAOYSA-N 0.000 abstract 1
- CFHPTZFRFWGDPD-UHFFFAOYSA-N NC1=CC(Cl)=NC(N)=[N+]1[O-] Chemical compound NC1=CC(Cl)=NC(N)=[N+]1[O-] CFHPTZFRFWGDPD-UHFFFAOYSA-N 0.000 abstract 1
- QAQROVACAQJKSW-UHFFFAOYSA-N NC1=NC(N)=CC(N2CCCCC2)=[N+]1[O-] Chemical compound NC1=NC(N)=CC(N2CCCCC2)=[N+]1[O-] QAQROVACAQJKSW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8720436A IT1212140B (it) | 1987-05-08 | 1987-05-08 | Processo per la preparazione del 2,4-diammino-6-(1-piperidinil)-piri mi-din-n-ossido. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3872956D1 true DE3872956D1 (de) | 1992-08-27 |
| DE3872956T2 DE3872956T2 (de) | 1992-12-03 |
Family
ID=11166913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888830189T Expired - Lifetime DE3872956T2 (de) | 1987-05-08 | 1988-05-03 | Verfahren zur herstellung von 2,4-diamino-6-(1-piperidinyl)-pyramidin-n-oxid. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0295218B1 (de) |
| AT (1) | ATE78473T1 (de) |
| BE (1) | BE1000745A4 (de) |
| DE (1) | DE3872956T2 (de) |
| ES (1) | ES2042799T3 (de) |
| GR (1) | GR3006050T3 (de) |
| IT (1) | IT1212140B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI367208B (en) | 2004-11-12 | 2012-07-01 | Sumitomo Chemical Co | Production method of pyrimidine compounds |
| GB2451594A (en) * | 2006-03-15 | 2009-02-04 | Csir | Modulation of phosphoryl transferase activity of glutamine synthetase |
| WO2007105023A1 (en) * | 2006-03-15 | 2007-09-20 | Csir | Modulation of phosphoryl transferase activity of glutamine synthetase |
| CN107235919B (zh) * | 2017-06-22 | 2020-05-12 | 安徽拜善晟制药有限公司 | 一种米诺地尔的合成工艺 |
| CN110272391B (zh) * | 2019-07-03 | 2022-10-28 | 天津药物研究院药业有限责任公司 | 一种米诺地尔的精制方法 |
| CN114394941A (zh) * | 2022-02-16 | 2022-04-26 | 汉瑞药业(荆门)有限公司 | 一种2,4-二氨基-6-氯嘧啶的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3382248A (en) * | 1965-11-01 | 1968-05-07 | Upjohn Co | 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines |
-
1987
- 1987-05-08 IT IT8720436A patent/IT1212140B/it active
- 1987-07-16 BE BE8700791A patent/BE1000745A4/fr not_active IP Right Cessation
-
1988
- 1988-05-03 AT AT88830189T patent/ATE78473T1/de not_active IP Right Cessation
- 1988-05-03 EP EP88830189A patent/EP0295218B1/de not_active Expired - Lifetime
- 1988-05-03 DE DE8888830189T patent/DE3872956T2/de not_active Expired - Lifetime
- 1988-05-03 ES ES88830189T patent/ES2042799T3/es not_active Expired - Lifetime
-
1992
- 1992-10-22 GR GR920402375T patent/GR3006050T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE1000745A4 (fr) | 1989-03-28 |
| GR3006050T3 (de) | 1993-06-21 |
| ES2042799T3 (es) | 1993-12-16 |
| ATE78473T1 (de) | 1992-08-15 |
| EP0295218B1 (de) | 1992-07-22 |
| IT1212140B (it) | 1989-11-08 |
| DE3872956T2 (de) | 1992-12-03 |
| IT8720436A0 (it) | 1987-05-08 |
| EP0295218A1 (de) | 1988-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |