ATE134374T1 - Verfahren zur herstellung von kondensierten pyridinverbindungen - Google Patents

Verfahren zur herstellung von kondensierten pyridinverbindungen

Info

Publication number
ATE134374T1
ATE134374T1 AT88308250T AT88308250T ATE134374T1 AT E134374 T1 ATE134374 T1 AT E134374T1 AT 88308250 T AT88308250 T AT 88308250T AT 88308250 T AT88308250 T AT 88308250T AT E134374 T1 ATE134374 T1 AT E134374T1
Authority
AT
Austria
Prior art keywords
pyridine compounds
producing condensed
condensed pyridine
producing
ch2ch2coor
Prior art date
Application number
AT88308250T
Other languages
English (en)
Inventor
Edward C Taylor
Philip M Harrington
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Application granted granted Critical
Publication of ATE134374T1 publication Critical patent/ATE134374T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT88308250T 1987-10-26 1988-09-07 Verfahren zur herstellung von kondensierten pyridinverbindungen ATE134374T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11403087A 1987-10-26 1987-10-26
US07/186,015 US4895946A (en) 1987-10-26 1988-04-25 Process for the preparation of fused pyridine compounds

Publications (1)

Publication Number Publication Date
ATE134374T1 true ATE134374T1 (de) 1996-03-15

Family

ID=26811764

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88308250T ATE134374T1 (de) 1987-10-26 1988-09-07 Verfahren zur herstellung von kondensierten pyridinverbindungen

Country Status (7)

Country Link
US (2) US4895946A (de)
EP (1) EP0314280B1 (de)
JP (1) JPH01113389A (de)
AT (1) ATE134374T1 (de)
DE (1) DE3855017T2 (de)
ES (1) ES2083954T3 (de)
GR (1) GR3019898T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ[2,3―d]ピリミジン誘導体,その製造法,用途及び中間体
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0530537B1 (de) * 1991-08-12 1997-01-08 Takeda Chemical Industries, Ltd. Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
JPH09165387A (ja) * 1995-09-08 1997-06-24 Univ Princeton 非古典的抗葉酸剤
JP2001524927A (ja) * 1996-05-01 2001-12-04 ザ トラスティーズ オブ プリンストン ユニバーシティー 5,6,7,8―テトラヒドロピリド[2,3―d]ピリミジン類
US6066639A (en) * 1996-05-01 2000-05-23 The Trustees Of Princeton University 5,6,7,8-tetrahydropyrido[2,3-D]pyrimidines
CZ301563B6 (cs) * 1997-09-26 2010-04-14 Eli Lilly And Company Zpusob prípravy pyrrolopyrimidinových derivátu
AU739292B2 (en) * 1998-02-11 2001-10-11 Eli Lilly And Company Processes and intermediates useful to make antifolates
GB2358799A (en) * 2000-02-04 2001-08-08 Lilley Forschung Gmbh A pharmaceutical composition comprising pemetrexed and an antioxidant
US20040092739A1 (en) * 2002-11-13 2004-05-13 Zejun Xiao Process for synthesizing antifolates
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288792A (en) * 1962-07-05 1966-11-29 Burroughs Wellcome Co Method of preparing 2, 4-diamino-6-alkylpyrido (2, 3-d) pyrimidines
ZA803539B (en) * 1979-06-14 1982-01-27 Wellcome Found Alkoxybenzylrimidines method for their preparation formulation thereof and their use in medicine
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
FR2582802B1 (de) * 1985-05-28 1989-07-28 Sfena
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
US5223620A (en) * 1988-04-01 1993-06-29 Takeda Chemical Industries, Ltd. Pyrido[2,3-d]pyrimidine compounds useful as intermediates

Also Published As

Publication number Publication date
DE3855017D1 (de) 1996-03-28
EP0314280A3 (en) 1989-11-02
GR3019898T3 (en) 1996-08-31
EP0314280B1 (de) 1996-02-21
US4895946A (en) 1990-01-23
US5473071A (en) 1995-12-05
ES2083954T3 (es) 1996-05-01
EP0314280A2 (de) 1989-05-03
JPH01113389A (ja) 1989-05-02
DE3855017T2 (de) 1996-08-01

Similar Documents

Publication Publication Date Title
ATE134374T1 (de) Verfahren zur herstellung von kondensierten pyridinverbindungen
ATE150462T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
ATE122042T1 (de) Pyrazoloisoquinoline-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
AU7720891A (en) Novel intermediates for the preparation of novel 5(and/or 6) substituted 2(2-imidazolin-2-yl)nicotinic acids, esters and salts, useful as herbicidal agents
DE3774273D1 (de) Chinazolin-derivat, verfahren zu dessen herstellung und mittel zur behandlung von cerebraler disfunktion als aktiver inhaltsstoff.
ATE102926T1 (de) N,n'-carboxyl-bis-(4-ethyl-2,3-dioxo)-piperazin verfahren zu dessen herstellung und dessen verwendung.
ATE189219T1 (de) Verfahren zur herstellung von liponsaeure
DE59309380D1 (de) Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure
DE69015890T2 (de) Aerosole von Pyrido(1,2-a)pyrimidinen.
DE3888317D1 (de) Verfahren zur Herstellung von Phosphorsäurederivaten und Zwischenprodukten.
ATE78473T1 (de) Verfahren zur herstellung von 2,4-diamino-6-(1piperidinyl)-pyramidin-n-oxid.
DE68925951D1 (de) Chemisches Verfahren zur Herstellung des Antibiotikums L 17392 (Deglukoteicoplanin) und dessen Salze
CA2154668A1 (en) Condensed heterocyclic glutamic acid derivatives as antiproliferative agents
ATE156824T1 (de) Verfahren zur herstellung von pyrido(1,2- a>pyrimidinderivaten
ATE137236T1 (de) Verfahren zur herstellung von pyrido(1,2- a>pyrimidinderivaten
ATE57934T1 (de) Verfahren zur herstellung von griseolinsaeurederivaten.
EP0367671A3 (de) Beta-D-phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE157655T1 (de) Verfahren zur herstellung von gegebenfalls 2- substituierten 5-chlorimidazolen
DE69416117D1 (de) Verfahren zur herstellung von kondensierten carbapenemderivaten
ATE25680T1 (de) Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
DE3672926D1 (de) Verfahren zur herstellung von 6-amino-penicillansaeure-1,1-dioxyd durch oxydation von 6-amino-penicillansaeure.
DE59308686D1 (de) Verfahren zur Herstellung von Reduktionsprodukten von Derivaten der 4-Hydroxybuttersäure
DE68929429T2 (de) Verfahren zur Herstellung von Pyridin-2,3-Dicarbonsäure-Verbindungen
DE69303035D1 (de) Verfahren zur Herstellung von 1,4-Dihydroxy-2-Naphthalin-Carbonsäure
ATE66671T1 (de) Gamma-l-glutanyl-4-nitoanilid-derivate und verfahren zur bestimmung von gamma-gtp-aktivitaet unter verwendung dieser derivate.