DE3855017D1 - Verfahren zur Herstellung von kondensierten Pyridinverbindungen - Google Patents

Verfahren zur Herstellung von kondensierten Pyridinverbindungen

Info

Publication number
DE3855017D1
DE3855017D1 DE3855017T DE3855017T DE3855017D1 DE 3855017 D1 DE3855017 D1 DE 3855017D1 DE 3855017 T DE3855017 T DE 3855017T DE 3855017 T DE3855017 T DE 3855017T DE 3855017 D1 DE3855017 D1 DE 3855017D1
Authority
DE
Germany
Prior art keywords
preparation
pyridine compounds
condensed pyridine
condensed
ch2ch2coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3855017T
Other languages
English (en)
Other versions
DE3855017T2 (de
Inventor
Edward C Taylor
Philip M Harrington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Publication of DE3855017D1 publication Critical patent/DE3855017D1/de
Application granted granted Critical
Publication of DE3855017T2 publication Critical patent/DE3855017T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3855017T 1987-10-26 1988-09-07 Verfahren zur Herstellung von kondensierten Pyridinverbindungen Expired - Fee Related DE3855017T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11403087A 1987-10-26 1987-10-26
US07/186,015 US4895946A (en) 1987-10-26 1988-04-25 Process for the preparation of fused pyridine compounds

Publications (2)

Publication Number Publication Date
DE3855017D1 true DE3855017D1 (de) 1996-03-28
DE3855017T2 DE3855017T2 (de) 1996-08-01

Family

ID=26811764

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855017T Expired - Fee Related DE3855017T2 (de) 1987-10-26 1988-09-07 Verfahren zur Herstellung von kondensierten Pyridinverbindungen

Country Status (7)

Country Link
US (2) US4895946A (de)
EP (1) EP0314280B1 (de)
JP (1) JPH01113389A (de)
AT (1) ATE134374T1 (de)
DE (1) DE3855017T2 (de)
ES (1) ES2083954T3 (de)
GR (1) GR3019898T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0530537B1 (de) * 1991-08-12 1997-01-08 Takeda Chemical Industries, Ltd. Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
JPH09165387A (ja) * 1995-09-08 1997-06-24 Univ Princeton 非古典的抗葉酸剤
JP2001524927A (ja) * 1996-05-01 2001-12-04 ザ トラスティーズ オブ プリンストン ユニバーシティー ５，６，７，８―テトラヒドロピリド［２，３―ｄ］ピリミジン類
US6066639A (en) * 1996-05-01 2000-05-23 The Trustees Of Princeton University 5,6,7,8-tetrahydropyrido[2,3-D]pyrimidines
CZ301563B6 (cs) * 1997-09-26 2010-04-14 Eli Lilly And Company Zpusob prípravy pyrrolopyrimidinových derivátu
AU739292B2 (en) * 1998-02-11 2001-10-11 Eli Lilly And Company Processes and intermediates useful to make antifolates
GB2358799A (en) * 2000-02-04 2001-08-08 Lilley Forschung Gmbh A pharmaceutical composition comprising pemetrexed and an antioxidant
US20040092739A1 (en) * 2002-11-13 2004-05-13 Zejun Xiao Process for synthesizing antifolates
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288792A (en) * 1962-07-05 1966-11-29 Burroughs Wellcome Co Method of preparing 2, 4-diamino-6-alkylpyrido (2, 3-d) pyrimidines
ZA803539B (en) * 1979-06-14 1982-01-27 Wellcome Found Alkoxybenzylrimidines method for their preparation formulation thereof and their use in medicine
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
FR2582802B1 (de) * 1985-05-28 1989-07-28 Sfena
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
US5223620A (en) * 1988-04-01 1993-06-29 Takeda Chemical Industries, Ltd. Pyrido[2,3-d]pyrimidine compounds useful as intermediates

Also Published As

Publication number Publication date
EP0314280A3 (en) 1989-11-02
GR3019898T3 (en) 1996-08-31
EP0314280B1 (de) 1996-02-21
US4895946A (en) 1990-01-23
US5473071A (en) 1995-12-05
ATE134374T1 (de) 1996-03-15
ES2083954T3 (es) 1996-05-01
EP0314280A2 (de) 1989-05-03
JPH01113389A (ja) 1989-05-02
DE3855017T2 (de) 1996-08-01

Similar Documents

Publication Publication Date Title
DE3855017D1 (de) Verfahren zur Herstellung von kondensierten Pyridinverbindungen
ATE150462T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
FI906438A (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
DE3789599T2 (de) Verfahren zur Herstellung von kondensierten Pyridinverbindungen.
FI98067B (fi) Uusia alkyleenidiammoniumdiklavulanaattijohdannaisia, menetelmä niidenvalmistamiseksi samoin kuin niiden käyttö kalvulaanihapon puhdistamiseksi
PT83104B (en) Novel guanidinomethylbenzoic acid derivatives
AU7720891A (en) Novel intermediates for the preparation of novel 5(and/or 6) substituted 2(2-imidazolin-2-yl)nicotinic acids, esters and salts, useful as herbicidal agents
ATE122042T1 (de) Pyrazoloisoquinoline-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
NO850216L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte 5,11-dihydro-6-dibenz(b,e)-azepin-6-on-derivater
ATE48001T1 (de) Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
DE3774273D1 (de) Chinazolin-derivat, verfahren zu dessen herstellung und mittel zur behandlung von cerebraler disfunktion als aktiver inhaltsstoff.
DK18186A (da) Aminoacrylsyre-derivater, deres fremstilling og anvendelse, samt vedfremstillingen anvendelige mellemprodukter og fremstillingderaf
DE69015890T2 (de) Aerosole von Pyrido(1,2-a)pyrimidinen.
DE59309380D1 (de) Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure
DE3888317D1 (de) Verfahren zur Herstellung von Phosphorsäurederivaten und Zwischenprodukten.
DE3888513D1 (de) Derivate der 3,3'-Oxy-bis[2,2'-di(brommethyl)]propansäure, Verfahren zu ihrer Herstellung und ihre Verwendung als Flammverzögerungsmittel.
DE68925951D1 (de) Chemisches Verfahren zur Herstellung des Antibiotikums L 17392 (Deglukoteicoplanin) und dessen Salze
DE69127238D1 (de) Verfahren zur Herstellung von Pyrido[1,2-a]pyrimidinderivaten
DE69026638T2 (de) Verfahren zur Herstellung von Pyrido[1,2-a]pyrimidinderivaten
EP0367671A3 (de) Beta-D-phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE25680T1 (de) Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
DE3483011D1 (de) Substituierte alkylamino-derivate von 6,11-dihydro-11-oxo-dibenz(b,e)-oxepin, verfahren zu ihrer herstellung, ihre zwischenprodukte und ihre verwendung als arzneimittel.
ATE57934T1 (de) Verfahren zur herstellung von griseolinsaeurederivaten.
DE59308686D1 (de) Verfahren zur Herstellung von Reduktionsprodukten von Derivaten der 4-Hydroxybuttersäure
DE68929429T2 (de) Verfahren zur Herstellung von Pyridin-2,3-Dicarbonsäure-Verbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee