BE1000745A4 - Procede de preparation de 2,4-diamino-6-(1-piperidinyl)-pyrimidine-n-oxyde. - Google Patents

Procede de preparation de 2,4-diamino-6-(1-piperidinyl)-pyrimidine-n-oxyde. Download PDF

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Publication number
BE1000745A4
BE1000745A4 BE8700791A BE8700791A BE1000745A4 BE 1000745 A4 BE1000745 A4 BE 1000745A4 BE 8700791 A BE8700791 A BE 8700791A BE 8700791 A BE8700791 A BE 8700791A BE 1000745 A4 BE1000745 A4 BE 1000745A4
Authority
BE
Belgium
Prior art keywords
diamino
pyrimidine
oxide
piperidinyl
preparation
Prior art date
Application number
BE8700791A
Other languages
English (en)
Inventor
Claudio Botre
Original Assignee
Claudio Botre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Claudio Botre filed Critical Claudio Botre
Application granted granted Critical
Publication of BE1000745A4 publication Critical patent/BE1000745A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procédé de préparation du 2,4-diamino-6-(1-pipéridinyl)-pyrimidine-N-oxyde de la formule comprenant la réaction de 6-chloro-2,4-diaminopyrimidine avec un sel de magnésium d'acide monoperphtalique pour obtenir le 2,6-diamino-4-chloro-pyrimidine-N-oxyde que l'on fait réagir avec de la pipéridine pour obtenir le composé I susdit. Le composé présente des caractéristiques pharmacologiques, surtout qualité d'anti-hypertonique.
BE8700791A 1987-05-08 1987-07-16 Procede de preparation de 2,4-diamino-6-(1-piperidinyl)-pyrimidine-n-oxyde. BE1000745A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8720436A IT1212140B (it) 1987-05-08 1987-05-08 Processo per la preparazione del 2,4-diammino-6-(1-piperidinil)-piri mi-din-n-ossido.

Publications (1)

Publication Number Publication Date
BE1000745A4 true BE1000745A4 (fr) 1989-03-28

Family

ID=11166913

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700791A BE1000745A4 (fr) 1987-05-08 1987-07-16 Procede de preparation de 2,4-diamino-6-(1-piperidinyl)-pyrimidine-n-oxyde.

Country Status (7)

Country Link
EP (1) EP0295218B1 (fr)
AT (1) ATE78473T1 (fr)
BE (1) BE1000745A4 (fr)
DE (1) DE3872956T2 (fr)
ES (1) ES2042799T3 (fr)
GR (1) GR3006050T3 (fr)
IT (1) IT1212140B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367208B (en) 2004-11-12 2012-07-01 Sumitomo Chemical Co Production method of pyrimidine compounds
GB2451594A (en) * 2006-03-15 2009-02-04 Csir Modulation of phosphoryl transferase activity of glutamine synthetase
CN101438288A (zh) * 2006-03-15 2009-05-20 Csir公司 谷氨酰胺合成酶的磷酰基转移酶活性的调节
CN107235919B (zh) * 2017-06-22 2020-05-12 安徽拜善晟制药有限公司 一种米诺地尔的合成工艺
CN110272391B (zh) * 2019-07-03 2022-10-28 天津药物研究院药业有限责任公司 一种米诺地尔的精制方法
CN114394941A (zh) * 2022-02-16 2022-04-26 汉瑞药业(荆门)有限公司 一种2,4-二氨基-6-氯嘧啶的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382248A (en) * 1965-11-01 1968-05-07 Upjohn Co 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382248A (en) * 1965-11-01 1968-05-07 Upjohn Co 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines

Also Published As

Publication number Publication date
IT1212140B (it) 1989-11-08
GR3006050T3 (fr) 1993-06-21
EP0295218A1 (fr) 1988-12-14
DE3872956T2 (de) 1992-12-03
ES2042799T3 (es) 1993-12-16
DE3872956D1 (de) 1992-08-27
EP0295218B1 (fr) 1992-07-22
IT8720436A0 (it) 1987-05-08
ATE78473T1 (de) 1992-08-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ISTITUTO FARMACOLOGICO SERONO

Effective date: 19940731