ES2124748T3 - Nuevo proceso para la produccion de ceftriaxona. - Google Patents

Nuevo proceso para la produccion de ceftriaxona.

Info

Publication number
ES2124748T3
ES2124748T3 ES93102381T ES93102381T ES2124748T3 ES 2124748 T3 ES2124748 T3 ES 2124748T3 ES 93102381 T ES93102381 T ES 93102381T ES 93102381 T ES93102381 T ES 93102381T ES 2124748 T3 ES2124748 T3 ES 2124748T3
Authority
ES
Spain
Prior art keywords
ceftriaxone
production
new process
methyl
disodium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93102381T
Other languages
English (en)
Inventor
Johann Danklmaier
Ingolf Macher
Bernhard Prager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Application granted granted Critical
Publication of ES2124748T3 publication Critical patent/ES2124748T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA PRODUCCION DE HEMIHEPTAHIDRATO DE SAL DE DISODIO DE CEFTRIAXONA MEDIANTE LA REACCION DE ACIDO 7-AMINO-3-{[(2,5-DIHIDRO-6-HIDROXI-2-METIL-5OXO-1,2,4-TRIZIN-3-IL)TIO]METIL}-3-CEFEM-4-CARBOXILICO CON (2BENZOTIAZOLIL)TIOLESTER DE ACIDO 2-(AMINOTIAZOL-4-IL)-2-SYNMETOXIMNOACETICO EN LA PRESENCIA DE UNA BASE, QUE SE CARACTERIZA EN QUE LA REACCION Y LA CRITALIZACION DEL HEMIHEPTAHIDRATO DE LA SAL DE DISODIO DE CEFTRIAXONA ESTA SOPORTADO EN ACETONA ACUOSA.
ES93102381T 1992-02-20 1993-02-16 Nuevo proceso para la produccion de ceftriaxona. Expired - Lifetime ES2124748T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0030992A AT399877B (de) 1992-02-20 1992-02-20 Neues verfahren zur herstellung von ceftriaxon

Publications (1)

Publication Number Publication Date
ES2124748T3 true ES2124748T3 (es) 1999-02-16

Family

ID=3487145

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93102381T Expired - Lifetime ES2124748T3 (es) 1992-02-20 1993-02-16 Nuevo proceso para la produccion de ceftriaxona.

Country Status (7)

Country Link
US (1) US5574155A (es)
EP (1) EP0556768B1 (es)
JP (1) JP2609039B2 (es)
AT (2) AT399877B (es)
DE (1) DE69321749T2 (es)
ES (1) ES2124748T3 (es)
SG (1) SG47054A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
KR100361829B1 (ko) * 1997-04-16 2005-08-17 주식회사 엘지생명과학 반응성 유기산 유도체로 부터 세프트리악손을 제조하는 방법
WO2000063214A1 (en) * 1999-04-15 2000-10-26 Biochemie Gesellschaft M B H Beta-lactam production
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
ES2348299T3 (es) 2003-04-16 2010-12-02 Sandoz Ag Procedimientos para la preparación de cefepime.
WO2004111059A1 (en) * 2003-06-19 2004-12-23 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of a cephalosporin antibiotic
US20050059820A1 (en) * 2003-09-17 2005-03-17 Debashish Datta Method for manufacture of ceftriaxone sodium
CN101210020B (zh) * 2006-12-31 2010-11-24 山东轩竹医药科技有限公司 新型头孢菌素化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1240314A (en) * 1974-06-21 1988-08-09 Marc Montavon Acyl derivatives
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
CH641468A5 (de) * 1978-05-30 1984-02-29 Hoffmann La Roche Cephemderivate.
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FI67385C (fi) * 1979-11-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
KR870001332B1 (ko) * 1984-09-27 1987-07-18 한미약품공업 주식회사 세펨 유도체의 간단한 제조방법
KR890002107B1 (ko) * 1986-06-25 1989-06-19 재단법인 한국화학연구소 세팔로스포린 유도체의 제조방법
DE3911322A1 (de) * 1989-04-07 1990-10-11 Hoechst Ag Verfahren zur herstellung von cefodizim-dinatrium
IT1234385B (it) * 1989-05-23 1992-05-18 Sbd Synthetic And Biolog Devel Procedimento migliorato per la produzione di una sostanza antibiotica appartenente al gruppo delle cefalosporine
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat

Also Published As

Publication number Publication date
EP0556768A2 (en) 1993-08-25
ATA30992A (de) 1994-12-15
AT399877B (de) 1995-08-25
ATE172734T1 (de) 1998-11-15
EP0556768B1 (en) 1998-10-28
JPH069648A (ja) 1994-01-18
EP0556768A3 (en) 1993-11-24
DE69321749T2 (de) 1999-04-22
SG47054A1 (en) 1998-03-20
JP2609039B2 (ja) 1997-05-14
DE69321749D1 (de) 1998-12-03
US5574155A (en) 1996-11-12

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