FI892386A - Menetelmä enantiomeeristen glutaarihappoamidipohjaisten virtsaneritystä lisäävien yhdisteiden valmistamiseksi - Google Patents

Menetelmä enantiomeeristen glutaarihappoamidipohjaisten virtsaneritystä lisäävien yhdisteiden valmistamiseksi Download PDF

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Publication number
FI892386A
FI892386A FI892386A FI892386A FI892386A FI 892386 A FI892386 A FI 892386A FI 892386 A FI892386 A FI 892386A FI 892386 A FI892386 A FI 892386A FI 892386 A FI892386 A FI 892386A
Authority
FI
Finland
Prior art keywords
enantiomeric
preparation
acid amide
glutaric acid
urinary excretion
Prior art date
Application number
FI892386A
Other languages
English (en)
Swedish (sv)
Other versions
FI93541B (fi
FI892386A0 (fi
FI93541C (fi
Inventor
John Christopher Danilewicz
Michael Trevelyan Williams
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI892386A0 publication Critical patent/FI892386A0/fi
Publication of FI892386A publication Critical patent/FI892386A/fi
Publication of FI93541B publication Critical patent/FI93541B/fi
Application granted granted Critical
Publication of FI93541C publication Critical patent/FI93541C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI892386A 1988-05-19 1989-05-18 Menetelmä enantiomeeristen glutaarihappoamidipohjaisten virtsaneritystä lisäävien yhdisteiden valmistamiseksi FI93541C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888811873A GB8811873D0 (en) 1988-05-19 1988-05-19 Therapeutic agents
GB8811873 1988-05-19

Publications (4)

Publication Number Publication Date
FI892386A0 FI892386A0 (fi) 1989-05-18
FI892386A true FI892386A (fi) 1989-11-20
FI93541B FI93541B (fi) 1995-01-13
FI93541C FI93541C (fi) 1995-04-25

Family

ID=10637176

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892386A FI93541C (fi) 1988-05-19 1989-05-18 Menetelmä enantiomeeristen glutaarihappoamidipohjaisten virtsaneritystä lisäävien yhdisteiden valmistamiseksi

Country Status (29)

Country Link
EP (1) EP0342850B1 (fi)
JP (1) JPH072699B2 (fi)
KR (1) KR920000561B1 (fi)
CN (1) CN1015361B (fi)
AT (1) ATE76399T1 (fi)
AU (1) AU602813B2 (fi)
CA (1) CA1331197C (fi)
CS (1) CS274502B2 (fi)
DD (1) DD283772A5 (fi)
DE (1) DE68901582D1 (fi)
DK (1) DK172032B1 (fi)
EG (1) EG19007A (fi)
ES (1) ES2037418T3 (fi)
FI (1) FI93541C (fi)
GB (1) GB8811873D0 (fi)
GR (1) GR3004968T3 (fi)
HU (1) HU205067B (fi)
IE (1) IE60724B1 (fi)
IL (1) IL90267A (fi)
MX (1) MX16067A (fi)
MY (1) MY104735A (fi)
NO (1) NO173647C (fi)
NZ (1) NZ229186A (fi)
PH (1) PH26740A (fi)
PL (1) PL154813B1 (fi)
PT (1) PT90584B (fi)
SU (1) SU1766251A3 (fi)
YU (1) YU47973B (fi)
ZA (1) ZA893696B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
GB9000725D0 (en) * 1990-01-12 1990-03-14 Pfizer Ltd Therapeutic agents
EP0644176B1 (en) * 1993-09-22 1995-11-15 Pfizer Limited Hydrogenation
US7468390B2 (en) 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
SI2887961T1 (sl) 2012-08-24 2021-08-31 Novartis Ag Zaviralci NEP za zdravljenje bolezni, značilnih po atrialni širitvi ali preoblikovanju
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
WO2017072636A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical synergistic combination

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제

Also Published As

Publication number Publication date
YU102289A (en) 1991-06-30
GB8811873D0 (en) 1988-06-22
DK240889A (da) 1989-11-20
IE60724B1 (en) 1994-08-10
NO892002L (no) 1989-11-20
DE68901582D1 (de) 1992-06-25
FI93541B (fi) 1995-01-13
DK172032B1 (da) 1997-09-22
NZ229186A (en) 1990-10-26
NO892002D0 (no) 1989-05-18
IL90267A0 (en) 1989-12-15
PT90584B (pt) 1994-09-30
NO173647C (no) 1994-01-12
PL154813B1 (en) 1991-09-30
PH26740A (en) 1992-09-28
ATE76399T1 (de) 1992-06-15
KR900017993A (ko) 1990-12-20
MY104735A (en) 1994-05-31
JPH0222256A (ja) 1990-01-25
NO173647B (no) 1993-10-04
HU205067B (en) 1992-03-30
GR3004968T3 (fi) 1993-04-28
EP0342850B1 (en) 1992-05-20
PL279491A1 (en) 1989-11-27
AU602813B2 (en) 1990-10-25
CN1015361B (zh) 1992-02-05
EG19007A (en) 1994-11-30
CN1037704A (zh) 1989-12-06
MX16067A (es) 1993-10-01
SU1766251A3 (ru) 1992-09-30
FI892386A0 (fi) 1989-05-18
AU3490489A (en) 1989-11-23
JPH072699B2 (ja) 1995-01-18
IL90267A (en) 1993-08-18
DK240889D0 (da) 1989-05-18
IE891613L (en) 1989-11-19
FI93541C (fi) 1995-04-25
HUT53596A (en) 1990-11-28
CS296589A2 (en) 1990-09-12
PT90584A (pt) 1989-11-30
ZA893696B (en) 1990-12-28
ES2037418T3 (es) 1993-06-16
KR920000561B1 (ko) 1992-01-16
CA1331197C (en) 1994-08-02
DD283772A5 (de) 1990-10-24
CS274502B2 (en) 1991-04-11
EP0342850A1 (en) 1989-11-23
YU47973B (sh) 1996-08-13

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BB Publication of examined application
MM Patent lapsed

Owner name: PFIZER INC.