JPS6440458A - Production of azacycloalkane-2-one compound - Google Patents

Production of azacycloalkane-2-one compound

Info

Publication number
JPS6440458A
JPS6440458A JP19611587A JP19611587A JPS6440458A JP S6440458 A JPS6440458 A JP S6440458A JP 19611587 A JP19611587 A JP 19611587A JP 19611587 A JP19611587 A JP 19611587A JP S6440458 A JPS6440458 A JP S6440458A
Authority
JP
Japan
Prior art keywords
compound
formula
analgesic
azacycloalkane
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP19611587A
Other languages
Japanese (ja)
Other versions
JPH0739386B2 (en
Inventor
Masayoshi Tsuji
Toshitaka Inoue
Terumi Yatani
Mikio Nakajima
Kanji Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP19611587A priority Critical patent/JPH0739386B2/en
Publication of JPS6440458A publication Critical patent/JPS6440458A/en
Publication of JPH0739386B2 publication Critical patent/JPH0739386B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I (X is S, SO, SO2, O or NH; R is antiphlogistic and analgesic compound having carboxyl group at the end; l is 1-15; m is 2-15; n is 2-7). EXAMPLE:2-[{2-(2-Oxo-1-pyrrolidinyl)ethyl}thio] ethyl-d-2-(6-methoxy-2-naphthyl) propionate. USE:An antiphlogistics and analgesic remarkably reduced in side effect such as gastic disease. PREPARATION:An antiphlogistic and analgesic compound having carboxyl group at the end is reacted with thionyl chloride in an inert solvent (e.g. benzene or toluene) which does not participate in reaction under reflux for 1-5hr to give aid chloride compound, which is then reacted with azacycloalkane-2-one derivative expressed by formula II in the presence of a dehalogenating agent to provide the compound expressed by formula I.
JP19611587A 1987-08-04 1987-08-04 Azacycloalkane-2-one compound Expired - Lifetime JPH0739386B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP19611587A JPH0739386B2 (en) 1987-08-04 1987-08-04 Azacycloalkane-2-one compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19611587A JPH0739386B2 (en) 1987-08-04 1987-08-04 Azacycloalkane-2-one compound

Publications (2)

Publication Number Publication Date
JPS6440458A true JPS6440458A (en) 1989-02-10
JPH0739386B2 JPH0739386B2 (en) 1995-05-01

Family

ID=16352488

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19611587A Expired - Lifetime JPH0739386B2 (en) 1987-08-04 1987-08-04 Azacycloalkane-2-one compound

Country Status (1)

Country Link
JP (1) JPH0739386B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206386A (en) * 1991-03-20 1993-04-27 Isp Investments Inc. Controlled release N-substituted pyrrolidone esters and process for the use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206386A (en) * 1991-03-20 1993-04-27 Isp Investments Inc. Controlled release N-substituted pyrrolidone esters and process for the use thereof

Also Published As

Publication number Publication date
JPH0739386B2 (en) 1995-05-01

Similar Documents

Publication Publication Date Title
IL110321A0 (en) Intermediates to n-aryl and n-heteroarylamide and urea derivatives
AU697681B2 (en) Retroviral protease inhibiting compounds
AU5691990A (en) N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
JPS5553282A (en) Dibenzothiepin derivative and its preparation
FI892386A0 (en) Process for the preparation of enantiomeric glutaric acid amide-based urinary excretion enhancing compounds
JPS5551041A (en) Phenyl-fatty acid derivative
EP0103320A3 (en) Acetylsalicylic acid thioesters, a process for their preparation and pharmaceutical compositions containing them
JPS6440458A (en) Production of azacycloalkane-2-one compound
ES509782A0 (en) A PROCEDURE FOR THE PREPARATION OF NEW BISTERS OF METHANODIOL AND ETHANODIOL.
CS38584A2 (en) Zpusob pripravy 5 (2 alkoxyfenyl) thiazolidindionu
FI103885B1 (en) A process for the preparation of therapeutically active 1-benzyl-4-phenylpiperazine derivatives and compounds useful as intermediates
ATE146472T1 (en) CONVERSION PROCESS OF LORABEF DIHYDRATE INTO LORACARBEF MONOHYDRATE
CA2473422A1 (en) Preparation of 5-chlorimidazoles
AU4617193A (en) Heteroarenylpiperazines, a process for their preparation and their use as medicaments
JPS54128599A (en) Pyrrolobenzazepin derivative
JPS5726658A (en) 4r -4- 3-substituted carboxy-3-diazo-2-oxopropyl -2- azetidinone derivative and its preparation
DE3472257D1 (en) A novel derivative of benzoic acid
JPS6445334A (en) 2-(r)-halogeno-4-phenyl lactic acid derivative and production thereof
DE69011174D1 (en) Catecholamine ester.
ES2061535T3 (en) A METHOD FOR PREPARING AN ESTER COMPOUND OF BENZOPYRANOPYRIDINEACETIC ACID.
JPS5579381A (en) Benzothiazine dioxide derivative and its preparation
GR3024594T3 (en) Novel thiophene-2-carboxylic acid derivatives and process for their production
JPS5655373A (en) Quinolinoneiminecarboxylic acid, its preparation, and antiphlogistic and analgesic composition containing said compound
EP0338494A3 (en) 3-anilino-2-hydroxycarbonyl-4-thiophen-acetic acids
EP0338493A3 (en) Tetrahydro-4-phenylimino-3-thiophen-acetic acids

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term
FPAY Renewal fee payment (prs date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080501

Year of fee payment: 13