JPS6440458A - Production of azacycloalkane-2-one compound - Google Patents
Production of azacycloalkane-2-one compoundInfo
- Publication number
- JPS6440458A JPS6440458A JP19611587A JP19611587A JPS6440458A JP S6440458 A JPS6440458 A JP S6440458A JP 19611587 A JP19611587 A JP 19611587A JP 19611587 A JP19611587 A JP 19611587A JP S6440458 A JPS6440458 A JP S6440458A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- analgesic
- azacycloalkane
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (X is S, SO, SO2, O or NH; R is antiphlogistic and analgesic compound having carboxyl group at the end; l is 1-15; m is 2-15; n is 2-7). EXAMPLE:2-[{2-(2-Oxo-1-pyrrolidinyl)ethyl}thio] ethyl-d-2-(6-methoxy-2-naphthyl) propionate. USE:An antiphlogistics and analgesic remarkably reduced in side effect such as gastic disease. PREPARATION:An antiphlogistic and analgesic compound having carboxyl group at the end is reacted with thionyl chloride in an inert solvent (e.g. benzene or toluene) which does not participate in reaction under reflux for 1-5hr to give aid chloride compound, which is then reacted with azacycloalkane-2-one derivative expressed by formula II in the presence of a dehalogenating agent to provide the compound expressed by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19611587A JPH0739386B2 (en) | 1987-08-04 | 1987-08-04 | Azacycloalkane-2-one compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19611587A JPH0739386B2 (en) | 1987-08-04 | 1987-08-04 | Azacycloalkane-2-one compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6440458A true JPS6440458A (en) | 1989-02-10 |
JPH0739386B2 JPH0739386B2 (en) | 1995-05-01 |
Family
ID=16352488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP19611587A Expired - Lifetime JPH0739386B2 (en) | 1987-08-04 | 1987-08-04 | Azacycloalkane-2-one compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0739386B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206386A (en) * | 1991-03-20 | 1993-04-27 | Isp Investments Inc. | Controlled release N-substituted pyrrolidone esters and process for the use thereof |
-
1987
- 1987-08-04 JP JP19611587A patent/JPH0739386B2/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206386A (en) * | 1991-03-20 | 1993-04-27 | Isp Investments Inc. | Controlled release N-substituted pyrrolidone esters and process for the use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH0739386B2 (en) | 1995-05-01 |
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Legal Events
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R250 | Receipt of annual fees |
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EXPY | Cancellation because of completion of term | ||
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