KR900017993A - 거울상 이성체 글루타르아미드 이뇨제 - Google Patents

거울상 이성체 글루타르아미드 이뇨제 Download PDF

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KR900017993A
KR900017993A KR1019890006691A KR890006691A KR900017993A KR 900017993 A KR900017993 A KR 900017993A KR 1019890006691 A KR1019890006691 A KR 1019890006691A KR 890006691 A KR890006691 A KR 890006691A KR 900017993 A KR900017993 A KR 900017993A
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compound
formula
ethyl
benzyl
propyl
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KR1019890006691A
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KR920000561B1 (ko
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크리스토퍼 다니엘위쯔 존
트레벨얀 윌리암스 마이클
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원본미기재
화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음

Description

거울상 이성체 글루타르아미드 이뇨제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. R-거울상 이성질체가 실질적으로 유리된 일반식(Ⅱ)의 S-거울상 이성질체 화합물 및 이의 약제학적으로 허용되는 염.
    상기식에서, R 및 R4는 각각 H이거나, R 및 R4중 어느 하나는 수소이고 다른 것은 생물학적으로 불안정한 에스테르 그룹을 나타낸다.
  2. 상기 생물학적으로 불안정한 에스테르 그룹이 에틸, 벤질, 1-(2,2-디에틸부티릴옥시)에틸, 2- 에틸프로피오닐옥시메틸, 1-(2-에틸프로피오닐옥시)에틸, 1-(2,4-디메틸벤조일옥시)에틸, α-벤조일옥시벤질, 1-(벤조일옥시)에틸, 2-메틸-1-프로피오닐옥시-1-프로필, 2,4,6-프리케틸벤조일옥시메틸, 1-(2,4,6-트리메틸 벤조일옥시)에틸, 피발로일옥시메틸, 펜에틸, 펜프로필, 2,2,2-트리플루오로에틸, 1- 또는 2- 나프틸, 2,4-디메틸페닐, 4-t-부틸페닐 및 5-인다닐인 일반식(Ⅱ)의 화합물.
  3. (S)-시스-4-{1-[2-(5-인다닐옥시카보닐)-3-(2-메록시에톡시)프로필]-1-사이클로펜탄카복사미도}-1-사이클로헥산카복실산.
  4. (-)-가구-4-{1-[2-(5-인다닐옥시카보닐)-2-(2-메톡시에톡시)프로필]-1-사이클로펜탄카복사미도}-1-사이클로헥산카복실산.
  5. (S)-시스-4-{1-[2-카복시-3-(2-메록시에톡시)프로필]-1-사이클로펜탄카복사미도}-1-사이클로헥산카복실산.
  6. (+)-시스-4-{1-[2-카복시-3-(2-메록시에톡시)프로필]-1-사이클로펜탄카복사미도}-1-사이클로헥산카복실산.
  7. (a) 일반식(Ⅵ)의 S거울상 이성체 화합물을 일반식(Ⅹ)의 화합물과 커플링시키고, (b)R13및 R14중 어느 하나 또는 둘다를 제거하여 일반식(Ⅱ)의 모노-에스테르 또는 디카복실산 생물학적 수득하거나, (c)R13을 제거하고, 생성물을 에스테르화하여 생물학적으로 불한정한 에스테르 그룹을 제공하여 R14를 제거하여 R4가 H이고 R은 생물학적으로 불안정한 에스테르 그룹인 일반식(Ⅱ)의 생성물을 수득하는 단계를 포함함을 특징으로 하는, 제1항의 화합물의 제조방법.
    상기식에서, R13및 R14는 수소를 제외하고 R 및 R4에 대해 정의한 바와 같거나, 선택적으로 제거할 수 있는 카복실산 보호그룹이다.
  8. 제7항에 있어서, R13가 N-아세틸-(1R, 2S)-에페드린을 형성하고 R14가 에틸이며, 에스테르 그룹을 수소화시킨 다음 가수분해시킴으로써 제거하여 R 및 R4가 둘다 H인 일반식(Ⅱ)의 화합물을 수득하는 방법.
  9. 제7항에 있어서, R13이인다닐이고 R14가 벤질이며 언급된 벤질 그룹을 제거하여 R이 5-인다닐이고 R4가 H인 일반식(Ⅱ)의 화합물을 수득하는 방법.
  10. 제7항에 있어서, R13이3급-부틸이고 R14가 벤질이며 언급된 그룹을 제거하여 R 및 R4가 둘다 수소인 일반식(Ⅱ)의 화합물을 수득하는 방법.
  11. 제7항에 있어서, R13이3급-부틸이고 R14가 벤질이며 언급된 3급-부틸 그룹을 제거하고, 생성물을 에스테르화하여 R에 생물학적으로 불안정한 에스테르 그룹을 제공하며, 벤질 그룹을 제거하는 방법.
  12. 약제학적으로 허용되는 희석제 또는 담체와 함께, 제1항 내지 6항중 어느 한 항의 화합물 또는 이의 약제학적으로 허용되는 염을 함유함을 특징으로 하는 약제학적 조성물.
  13. 제1항 내지 6항중 어느 한 항에 있어서, 의학용으로 사용하기 위한, 특히 고혈압 및 심기능부전의 치료를위한 이뇨제로서 사용하기 위한 화합물 및 약제학적으로 허용되는 이의 염.
  14. 제7항의 일반식(Ⅳ)의 화합물.
  15. 제14항에 있어서, R13이 5-인다닐, 3급-부틸이거나 N-아세틸-(1R, 2S)-에페드린 에스테르를 형성하는 화합물.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019890006691A 1988-05-19 1989-05-19 거울상 이성체 글루타르아미드 이뇨제 KR920000561B1 (ko)

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GB8811873.2 1988-05-19
US8811873.2 1988-05-19
GB888811873A GB8811873D0 (en) 1988-05-19 1988-05-19 Therapeutic agents

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KR900017993A true KR900017993A (ko) 1990-12-20
KR920000561B1 KR920000561B1 (ko) 1992-01-16

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EP (1) EP0342850B1 (ko)
JP (1) JPH072699B2 (ko)
KR (1) KR920000561B1 (ko)
CN (1) CN1015361B (ko)
AT (1) ATE76399T1 (ko)
AU (1) AU602813B2 (ko)
CA (1) CA1331197C (ko)
CS (1) CS274502B2 (ko)
DD (1) DD283772A5 (ko)
DE (1) DE68901582D1 (ko)
DK (1) DK172032B1 (ko)
EG (1) EG19007A (ko)
ES (1) ES2037418T3 (ko)
FI (1) FI93541C (ko)
GB (1) GB8811873D0 (ko)
GR (1) GR3004968T3 (ko)
HU (1) HU205067B (ko)
IE (1) IE60724B1 (ko)
IL (1) IL90267A (ko)
MX (1) MX16067A (ko)
MY (1) MY104735A (ko)
NO (1) NO173647C (ko)
NZ (1) NZ229186A (ko)
PH (1) PH26740A (ko)
PL (1) PL154813B1 (ko)
PT (1) PT90584B (ko)
SU (1) SU1766251A3 (ko)
YU (1) YU47973B (ko)
ZA (1) ZA893696B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
GB9000725D0 (en) * 1990-01-12 1990-03-14 Pfizer Ltd Therapeutic agents
DE69300826T2 (de) * 1993-09-22 1996-04-18 Pfizer Research And Development Co., N.V./S.A., Dublin Hydrierung.
US7468390B2 (en) 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
CN108685889A (zh) 2012-08-24 2018-10-23 诺华股份有限公司 用于治疗特征为心房增大或重构的疾病的nep抑制剂
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
US20180311241A1 (en) 2015-10-29 2018-11-01 Cadila Healthcare Limited Pharmaceutical synergistic combination

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제

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GB8811873D0 (en) 1988-06-22
ATE76399T1 (de) 1992-06-15
IL90267A0 (en) 1989-12-15
JPH072699B2 (ja) 1995-01-18
CN1015361B (zh) 1992-02-05
PH26740A (en) 1992-09-28
ES2037418T3 (es) 1993-06-16
ZA893696B (en) 1990-12-28
PT90584A (pt) 1989-11-30
FI892386A0 (fi) 1989-05-18
GR3004968T3 (ko) 1993-04-28
CS274502B2 (en) 1991-04-11
EP0342850A1 (en) 1989-11-23
MX16067A (es) 1993-10-01
YU102289A (en) 1991-06-30
EP0342850B1 (en) 1992-05-20
CA1331197C (en) 1994-08-02
NO173647C (no) 1994-01-12
AU3490489A (en) 1989-11-23
YU47973B (sh) 1996-08-13
NO173647B (no) 1993-10-04
FI93541C (fi) 1995-04-25
NO892002L (no) 1989-11-20
DE68901582D1 (de) 1992-06-25
IL90267A (en) 1993-08-18
HUT53596A (en) 1990-11-28
NO892002D0 (no) 1989-05-18
PL154813B1 (en) 1991-09-30
FI93541B (fi) 1995-01-13
FI892386A (fi) 1989-11-20
NZ229186A (en) 1990-10-26
DD283772A5 (de) 1990-10-24
DK240889A (da) 1989-11-20
HU205067B (en) 1992-03-30
CN1037704A (zh) 1989-12-06
JPH0222256A (ja) 1990-01-25
IE891613L (en) 1989-11-19
IE60724B1 (en) 1994-08-10
AU602813B2 (en) 1990-10-25
SU1766251A3 (ru) 1992-09-30
PT90584B (pt) 1994-09-30
EG19007A (en) 1994-11-30
KR920000561B1 (ko) 1992-01-16
MY104735A (en) 1994-05-31
CS296589A2 (en) 1990-09-12
DK240889D0 (da) 1989-05-18
PL279491A1 (en) 1989-11-27
DK172032B1 (da) 1997-09-22

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