KR900011720A - 글리신 유도체 및 그의 제조방법 - Google Patents

글리신 유도체 및 그의 제조방법 Download PDF

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Publication number
KR900011720A
KR900011720A KR1019900000186A KR900000186A KR900011720A KR 900011720 A KR900011720 A KR 900011720A KR 1019900000186 A KR1019900000186 A KR 1019900000186A KR 900000186 A KR900000186 A KR 900000186A KR 900011720 A KR900011720 A KR 900011720A
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South Korea
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compound
group
carboxyl group
formula
protected carboxyl
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KR1019900000186A
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English (en)
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다께오 이와꾸마
야스오 세끼네
야스히꼬 사사끼
이께자와 가쓰오
아끼오 오다와라
Original Assignee
지바따 이찌로
다나베 세이야꾸 가부시끼가이샤
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Publication of KR900011720A publication Critical patent/KR900011720A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

글리신 유도체 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기식(I)의 글리신 유도체 또는 그의 약리학적 허용가능 염.
    (상기 식중에서 R1은 치환된 또는 비치환된 페닐기, R2는 보호될 수 있는 카르복실기, Q는 저급 알키렌기및 m은 0 또는 1이다).
  2. 제1항에 있어서, R1이 페닐기 또는 할로게노페닐기인 화합물.
  3. 제2항에 있어서, R2가 유리 카르복실기 또는 저급 알콕시카르보닐기인 화합물.
  4. 제3항에 있어서, R1이 클로로페닐기이고, R2가 유리 카르복실기인 화합물.
  5. 제1항에 있어서, 상기 화합물이 {N-[2-(4-클로로페닐)술포닐아미노인단-5-일]}글리신, 메틸N-[2-(4-클로로페닐)술포닐아미노인단-5-일]글리시네이트, 3-{[[2-(4-클로로페닐) 술포닐아미노 인단-5-일]아미노] 아세틸아미노}-n-프로피온산, 4-{[[2-(4-클로로페닐)술포닐 아미노인단-5-일]아미노]아세틸아미노}-n-부티르산, 및 그의 약리학적 허용 가능염 중에서 선택된 화합물.
  6. (1) 하기식(II)의 화합물 또는 그의 염과 하기식(III)의 화합물의 축합 반응, 또는 (2) 하기식(IV)의 화합물과 하기식(V)의 술폰산 화합물 또는 그의 반응성 유도체의 축합 반응, 및(3) R21이 보호된 카르복실기일 때, 원한다면, 보호기의 제거를, 특징으로 하는 하기식(I)의 글리신 유도체 또는 그의 약리학적 허용 가능염의 제조방법.
    (상기식중에서, R1은 치환된 또는 비치환된 페닐기, R2는 보호될 수 있는 카르복실기, R21은 보호될 수 있는 카르복실기, X는 반응성 잔기, Q는 저급 알킬렌기, 및 m은 0또는 1을 나타낸다)
  7. 하기식(I-a)의 화합물 또는 그의 카르복실기의 부위 반응성 유도체 및 하기식(VI)의 아민 화합물 또는 그의 염의 축합반응, 및 R21이 보호된 카르복실기일때, 원한다면, 보호기의 제거를 특징으로 하는 하기식(A)의 글리신 유도체 및 그의 약리학적 허용 가능염의 제조방법.
    (상기식중에서, R1은 치환된 또는 비치환된 페닐기, R2는 보호될 수 있는 카르복실기, R21은 보호될 수 있는 카르복실기, 및 Q는 저급 알킬렌기이다).
  8. 제1항의 화합물 및 그의 약학적 허용 가능염의 치료유효량을 포함함을 특징으로 하는 약학적 조성물.
  9. 혈전중, 관상 및 뇌 혈관의 평할근 경련, 및 천식의 예방 또는 치료에 효과적인 약물 제조를 위한 제1내지 5항중 어느 한항에 따른 화합물의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900000186A 1989-01-10 1990-01-09 글리신 유도체 및 그의 제조방법 KR900011720A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP89-3548 1989-01-10
JP1003548A JPH0662547B2 (ja) 1989-01-10 1989-01-10 グリシン誘導体

Publications (1)

Publication Number Publication Date
KR900011720A true KR900011720A (ko) 1990-08-02

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KR1019900000186A KR900011720A (ko) 1989-01-10 1990-01-09 글리신 유도체 및 그의 제조방법

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Country Link
US (1) US4963587A (ko)
EP (1) EP0377977A1 (ko)
JP (1) JPH0662547B2 (ko)
KR (1) KR900011720A (ko)
CA (1) CA2004604A1 (ko)
FR (1) FR2641534B1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5442055A (en) * 1992-11-13 1995-08-15 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
FR2803848B1 (fr) * 2000-01-19 2002-02-15 Adir Nouveaux derives de benzenesulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1316998B1 (it) * 2000-03-02 2003-05-26 Sigma Tau Healthscience Spa Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori.
KR101247137B1 (ko) 2011-03-23 2013-04-01 주식회사 엠씨켐 Ｎ-[ｏ-(ｐ-피발로일옥시벤젠술포닐아미노)벤조일]글리신의 신규 제조 방법 및 그 모노나트륨염ㆍ4 수화물의 동결 건조 제제의 제조 방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190371B (it) * 1985-06-19 1988-02-16 Zambon Spa Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH02231464A (ja) * 1988-02-26 1990-09-13 Tanabe Seiyaku Co Ltd インダンオキシ酢酸誘導体

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US4963587A (en) 1990-10-16
EP0377977A1 (en) 1990-07-18
JPH02184662A (ja) 1990-07-19
CA2004604A1 (en) 1990-07-10
FR2641534B1 (fr) 1991-10-11
FR2641534A1 (fr) 1990-07-13
JPH0662547B2 (ja) 1994-08-17

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