IT1190371B - Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico - Google Patents

Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico

Info

Publication number
IT1190371B
IT1190371B IT21215/85A IT2121585A IT1190371B IT 1190371 B IT1190371 B IT 1190371B IT 21215/85 A IT21215/85 A IT 21215/85A IT 2121585 A IT2121585 A IT 2121585A IT 1190371 B IT1190371 B IT 1190371B
Authority
IT
Italy
Prior art keywords
fluoro
methyl
acetic acid
cis
preparation
Prior art date
Application number
IT21215/85A
Other languages
English (en)
Other versions
IT8521215A0 (it
Inventor
Mariano Meneghin
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IT21215/85A priority Critical patent/IT1190371B/it
Publication of IT8521215A0 publication Critical patent/IT8521215A0/it
Priority to US06/875,405 priority patent/US4748271A/en
Priority to DE8686108310T priority patent/DE3662882D1/de
Priority to AT86108310T priority patent/ATE42278T1/de
Priority to EP86108310A priority patent/EP0206241B1/en
Priority to JP61143992A priority patent/JPH0733368B2/ja
Application granted granted Critical
Publication of IT1190371B publication Critical patent/IT1190371B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
IT21215/85A 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico IT1190371B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT21215/85A IT1190371B (it) 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico
US06/875,405 US4748271A (en) 1985-06-19 1986-06-17 Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methyl-thiobenzylidene)-indene-3-acetic acid
DE8686108310T DE3662882D1 (en) 1985-06-19 1986-06-18 Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid
AT86108310T ATE42278T1 (de) 1985-06-19 1986-06-18 Verfahren zur herstellung von cis-5-fluor-2methyl-1-(4-methylthiobenzyliden)-indenyl-3essigs|ure.
EP86108310A EP0206241B1 (en) 1985-06-19 1986-06-18 Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid
JP61143992A JPH0733368B2 (ja) 1985-06-19 1986-06-19 シス−５−フルオロ−２−メチル−１−（４−メチルチオベンジリデン）−インデン−３−酢酸の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21215/85A IT1190371B (it) 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico

Publications (2)

Publication Number Publication Date
IT8521215A0 IT8521215A0 (it) 1985-06-19
IT1190371B true IT1190371B (it) 1988-02-16

Family

ID=11178502

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21215/85A IT1190371B (it) 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico

Country Status (6)

Country Link
US (1) US4748271A (it)
EP (1) EP0206241B1 (it)
JP (1) JPH0733368B2 (it)
AT (1) ATE42278T1 (it)
DE (1) DE3662882D1 (it)
IT (1) IT1190371B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH0662547B2 (ja) * 1989-01-10 1994-08-17 田辺製薬株式会社 グリシン誘導体
US5093356A (en) * 1990-01-16 1992-03-03 Merck Frosst Canada, Inc. Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
US5817693A (en) 1991-11-05 1998-10-06 Cousins; Russell Donovan Endothelin receptor antagonists
DK0612244T3 (da) * 1991-11-05 2002-01-14 Smithkline Beecham Corp Endothelinreceptorantagonister
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
IT1315233B1 (it) * 1999-10-04 2003-02-03 Zambon Spa Processo per la preparazione dell'acido cis 5-fluoro -2-metil-1-/p-(metiltio) benziliden/inden-3-acetico.
CN111233706A (zh) * 2020-01-19 2020-06-05 安徽峆一药业股份有限公司 一种舒林酸的绿色合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692651A (en) * 1970-05-01 1972-09-19 Meyer Sletzinger Process for preparing cis 5-fluoro-2-methyl - 1 - (p-methylsulfinylbenzylidene)-3-indenyl acetic acid
US3647858A (en) * 1970-05-01 1972-03-07 Merck & Co Inc Process for preparing 1-benzylidene-3-indenyl acetic acids
US3654349A (en) * 1970-05-01 1972-04-04 Merck & Co Inc Substituted indenyl acetic acids
US3766259A (en) * 1970-05-01 1973-10-16 Merck & Co Inc Preparation of 1-aryl-3-indenyl acetic acids
US3932498A (en) * 1971-01-21 1976-01-13 Merck & Co., Inc. 3-Indenyl-γ-(ketobutyric)-acid compounds
US3998875A (en) * 1974-10-02 1976-12-21 Merck & Co., Inc. Process of preparing 5-fluoro-2-methyl-1-(paramethylsulfinylbenzylidene)-indenyl-3-acetic acid

Also Published As

Publication number Publication date
EP0206241A1 (en) 1986-12-30
IT8521215A0 (it) 1985-06-19
JPH0733368B2 (ja) 1995-04-12
US4748271A (en) 1988-05-31
EP0206241B1 (en) 1989-04-19
DE3662882D1 (en) 1989-05-24
ATE42278T1 (de) 1989-05-15
JPS6258A (ja) 1987-01-06

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