IT1190371B - Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico - Google Patents

Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico

Info

Publication number
IT1190371B
IT1190371B IT21215/85A IT2121585A IT1190371B IT 1190371 B IT1190371 B IT 1190371B IT 21215/85 A IT21215/85 A IT 21215/85A IT 2121585 A IT2121585 A IT 2121585A IT 1190371 B IT1190371 B IT 1190371B
Authority
IT
Italy
Prior art keywords
fluoro
methyl
acetic acid
cis
preparation
Prior art date
Application number
IT21215/85A
Other languages
English (en)
Other versions
IT8521215A0 (it
Inventor
Mariano Meneghin
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IT21215/85A priority Critical patent/IT1190371B/it
Publication of IT8521215A0 publication Critical patent/IT8521215A0/it
Priority to US06/875,405 priority patent/US4748271A/en
Priority to AT86108310T priority patent/ATE42278T1/de
Priority to DE8686108310T priority patent/DE3662882D1/de
Priority to EP86108310A priority patent/EP0206241B1/en
Priority to JP61143992A priority patent/JPH0733368B2/ja
Application granted granted Critical
Publication of IT1190371B publication Critical patent/IT1190371B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT21215/85A 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico IT1190371B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT21215/85A IT1190371B (it) 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico
US06/875,405 US4748271A (en) 1985-06-19 1986-06-17 Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methyl-thiobenzylidene)-indene-3-acetic acid
AT86108310T ATE42278T1 (de) 1985-06-19 1986-06-18 Verfahren zur herstellung von cis-5-fluor-2methyl-1-(4-methylthiobenzyliden)-indenyl-3essigs|ure.
DE8686108310T DE3662882D1 (en) 1985-06-19 1986-06-18 Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid
EP86108310A EP0206241B1 (en) 1985-06-19 1986-06-18 Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid
JP61143992A JPH0733368B2 (ja) 1985-06-19 1986-06-19 シス−５−フルオロ−２−メチル−１−（４−メチルチオベンジリデン）−インデン−３−酢酸の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21215/85A IT1190371B (it) 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico

Publications (2)

Publication Number Publication Date
IT8521215A0 IT8521215A0 (it) 1985-06-19
IT1190371B true IT1190371B (it) 1988-02-16

Family

ID=11178502

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21215/85A IT1190371B (it) 1985-06-19 1985-06-19 Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico

Country Status (6)

Country Link
US (1) US4748271A (it)
EP (1) EP0206241B1 (it)
JP (1) JPH0733368B2 (it)
AT (1) ATE42278T1 (it)
DE (1) DE3662882D1 (it)
IT (1) IT1190371B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH0662547B2 (ja) * 1989-01-10 1994-08-17 田辺製薬株式会社 グリシン誘導体
US5093356A (en) * 1990-01-16 1992-03-03 Merck Frosst Canada, Inc. Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
US5817693A (en) 1991-11-05 1998-10-06 Cousins; Russell Donovan Endothelin receptor antagonists
DK0612244T3 (da) * 1991-11-05 2002-01-14 Smithkline Beecham Corp Endothelinreceptorantagonister
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
IT1315233B1 (it) * 1999-10-04 2003-02-03 Zambon Spa Processo per la preparazione dell'acido cis 5-fluoro -2-metil-1-/p-(metiltio) benziliden/inden-3-acetico.
CN111233706A (zh) * 2020-01-19 2020-06-05 安徽峆一药业股份有限公司 一种舒林酸的绿色合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692651A (en) * 1970-05-01 1972-09-19 Meyer Sletzinger Process for preparing cis 5-fluoro-2-methyl - 1 - (p-methylsulfinylbenzylidene)-3-indenyl acetic acid
US3654349A (en) * 1970-05-01 1972-04-04 Merck & Co Inc Substituted indenyl acetic acids
US3766259A (en) * 1970-05-01 1973-10-16 Merck & Co Inc Preparation of 1-aryl-3-indenyl acetic acids
US3647858A (en) * 1970-05-01 1972-03-07 Merck & Co Inc Process for preparing 1-benzylidene-3-indenyl acetic acids
US3932498A (en) * 1971-01-21 1976-01-13 Merck & Co., Inc. 3-Indenyl-γ-(ketobutyric)-acid compounds
US3998875A (en) * 1974-10-02 1976-12-21 Merck & Co., Inc. Process of preparing 5-fluoro-2-methyl-1-(paramethylsulfinylbenzylidene)-indenyl-3-acetic acid

Also Published As

Publication number Publication date
IT8521215A0 (it) 1985-06-19
JPH0733368B2 (ja) 1995-04-12
EP0206241B1 (en) 1989-04-19
DE3662882D1 (en) 1989-05-24
EP0206241A1 (en) 1986-12-30
US4748271A (en) 1988-05-31
JPS6258A (ja) 1987-01-06
ATE42278T1 (de) 1989-05-15

Similar Documents

Publication Publication Date Title
IT1190371B (it) Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico
GB1515620A (en) Continuous production of alkyl acrylates free from ether
FR2611719B1 (fr) Procede de preparation en continu d'oximinosilanes
DE3670286D1 (de) Verfahren zur synthese von 4,4'-dihydroxydiphenylsulfon.
FI864900A (fi) Foerfarande foer framstaellning av 5-(2,5-dimetylfenoxi)-2,2-dimetylpentansyra.
HUT41779A (en) Process for n-alkylating dihydro-lisergic acid
JPS54138517A (en) Preparation of tertiary alkylisocyanate
GB1434320A (en) Process for formylating organic basic nitrogen compounds
ES2137151T3 (es) Procedimiento para la preparacion de acido 3-metilindazol-3-carboxilico.
JPS5627648A (en) Preparation of filler for chromatography
MX161725A (es) Proceso para la preparacion de n-metilantranilato de metilo
US5081275A (en) Process for the preparation of 2-fluorobenzonitrile from saccharin
DE3572171D1 (en) Theophylline-7-acetic acid ester of d,l-trans-sobrerol having mucosecretolytic-fluidizing and antibronchospastic activity, a process for its preparation and pharmaceutical compositions thereof
JPS5538329A (en) Preparation of polyethylenepolyamine
JPS57165341A (en) Preparation of pivaloyl chloride and benzoyl chloride
JPS5576881A (en) Preparation of high-purity coproporphyrin 3 alkali salt
JPS57188548A (en) Preparation of beta-chloroalanine
JPS6475494A (en) Production of n-acyl, o,s-dimethylphosphoroamidethioate
JPS54148743A (en) Production of methoclopramide
JPS5740447A (en) Preparation of 3-nitro-4- lower alkoxy aniline
JPS5262234A (en) Process for preparation of n_3'-hydroxyphenyl-2-methylbenzamide
JPS5540630A (en) Preparation of 2,2'-bis(4-(1,1,3,3-tetramethylbutyl) phenol) sulfide
JPS55127382A (en) Preparation of alpha-aroyl-gamma-butyrolactone
JPS5549397A (en) Preparation of 17alpha-methylsteroid
KR920007967A (ko) 케탈의 연속 제조방법