IT8521215A0 - Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico. - Google Patents
Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico.Info
- Publication number
- IT8521215A0 IT8521215A0 IT8521215A IT2121585A IT8521215A0 IT 8521215 A0 IT8521215 A0 IT 8521215A0 IT 8521215 A IT8521215 A IT 8521215A IT 2121585 A IT2121585 A IT 2121585A IT 8521215 A0 IT8521215 A0 IT 8521215A0
- Authority
- IT
- Italy
- Prior art keywords
- methylthiobenzyliden
- indenyl
- cis
- fluoro
- methyl
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21215/85A IT1190371B (it) | 1985-06-19 | 1985-06-19 | Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico |
US06/875,405 US4748271A (en) | 1985-06-19 | 1986-06-17 | Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methyl-thiobenzylidene)-indene-3-acetic acid |
AT86108310T ATE42278T1 (de) | 1985-06-19 | 1986-06-18 | Verfahren zur herstellung von cis-5-fluor-2methyl-1-(4-methylthiobenzyliden)-indenyl-3essigs|ure. |
DE8686108310T DE3662882D1 (en) | 1985-06-19 | 1986-06-18 | Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid |
EP86108310A EP0206241B1 (en) | 1985-06-19 | 1986-06-18 | Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid |
JP61143992A JPH0733368B2 (ja) | 1985-06-19 | 1986-06-19 | シス−5−フルオロ−2−メチル−1−(4−メチルチオベンジリデン)−インデン−3−酢酸の製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21215/85A IT1190371B (it) | 1985-06-19 | 1985-06-19 | Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8521215A0 true IT8521215A0 (it) | 1985-06-19 |
IT1190371B IT1190371B (it) | 1988-02-16 |
Family
ID=11178502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT21215/85A IT1190371B (it) | 1985-06-19 | 1985-06-19 | Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico |
Country Status (6)
Country | Link |
---|---|
US (1) | US4748271A (it) |
EP (1) | EP0206241B1 (it) |
JP (1) | JPH0733368B2 (it) |
AT (1) | ATE42278T1 (it) |
DE (1) | DE3662882D1 (it) |
IT (1) | IT1190371B (it) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3623944A1 (de) * | 1986-07-16 | 1988-02-11 | Thomae Gmbh Dr K | Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JPH0662547B2 (ja) * | 1989-01-10 | 1994-08-17 | 田辺製薬株式会社 | グリシン誘導体 |
US5093356A (en) * | 1990-01-16 | 1992-03-03 | Merck Frosst Canada, Inc. | Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
PL176250B1 (pl) * | 1991-11-05 | 1999-05-31 | Smithkline Beecham Corp | Sposób wytwarzania pochodnych indanu |
US5817693A (en) * | 1991-11-05 | 1998-10-06 | Cousins; Russell Donovan | Endothelin receptor antagonists |
US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
US6121321A (en) * | 1996-06-13 | 2000-09-19 | Cell Pathways, Inc. | Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions |
US6063818A (en) * | 1996-06-13 | 2000-05-16 | Cell Pathways Inc. | Substituted benzylidene indenyl formamides, acetamides and propionamides |
US5998477A (en) * | 1996-06-13 | 1999-12-07 | Cell Pathways Inc. | Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions |
US5965619A (en) * | 1996-06-13 | 1999-10-12 | Cell Pathways Inc. | Method for treating patients having precancerous lesions with substituted indene derivatives |
US5948779A (en) * | 1997-12-12 | 1999-09-07 | Cell Pathways, Inc. | Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes |
US6028116A (en) * | 1998-04-03 | 2000-02-22 | Cell Pathways, Inc. | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia |
IT1315233B1 (it) * | 1999-10-04 | 2003-02-03 | Zambon Spa | Processo per la preparazione dell'acido cis 5-fluoro -2-metil-1-/p-(metiltio) benziliden/inden-3-acetico. |
CN111233706A (zh) * | 2020-01-19 | 2020-06-05 | 安徽峆一药业股份有限公司 | 一种舒林酸的绿色合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654349A (en) * | 1970-05-01 | 1972-04-04 | Merck & Co Inc | Substituted indenyl acetic acids |
US3692651A (en) * | 1970-05-01 | 1972-09-19 | Meyer Sletzinger | Process for preparing cis 5-fluoro-2-methyl - 1 - (p-methylsulfinylbenzylidene)-3-indenyl acetic acid |
US3647858A (en) * | 1970-05-01 | 1972-03-07 | Merck & Co Inc | Process for preparing 1-benzylidene-3-indenyl acetic acids |
US3766259A (en) * | 1970-05-01 | 1973-10-16 | Merck & Co Inc | Preparation of 1-aryl-3-indenyl acetic acids |
US3932498A (en) * | 1971-01-21 | 1976-01-13 | Merck & Co., Inc. | 3-Indenyl-γ-(ketobutyric)-acid compounds |
US3998875A (en) * | 1974-10-02 | 1976-12-21 | Merck & Co., Inc. | Process of preparing 5-fluoro-2-methyl-1-(paramethylsulfinylbenzylidene)-indenyl-3-acetic acid |
-
1985
- 1985-06-19 IT IT21215/85A patent/IT1190371B/it active
-
1986
- 1986-06-17 US US06/875,405 patent/US4748271A/en not_active Expired - Lifetime
- 1986-06-18 EP EP86108310A patent/EP0206241B1/en not_active Expired
- 1986-06-18 DE DE8686108310T patent/DE3662882D1/de not_active Expired
- 1986-06-18 AT AT86108310T patent/ATE42278T1/de not_active IP Right Cessation
- 1986-06-19 JP JP61143992A patent/JPH0733368B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0206241A1 (en) | 1986-12-30 |
US4748271A (en) | 1988-05-31 |
EP0206241B1 (en) | 1989-04-19 |
DE3662882D1 (en) | 1989-05-24 |
JPS6258A (ja) | 1987-01-06 |
ATE42278T1 (de) | 1989-05-15 |
JPH0733368B2 (ja) | 1995-04-12 |
IT1190371B (it) | 1988-02-16 |
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