JPS57188548A - Preparation of beta-chloroalanine - Google Patents
Preparation of beta-chloroalanineInfo
- Publication number
- JPS57188548A JPS57188548A JP7352181A JP7352181A JPS57188548A JP S57188548 A JPS57188548 A JP S57188548A JP 7352181 A JP7352181 A JP 7352181A JP 7352181 A JP7352181 A JP 7352181A JP S57188548 A JPS57188548 A JP S57188548A
- Authority
- JP
- Japan
- Prior art keywords
- hcl
- aziridine
- objective compound
- carboxylic acid
- acid salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate of pharmaceuticals, easily, economically, in an industrial scale, by reacting an aziridine-2- carboxylic acid salt with a specific molar ratio of HCl in an aqueous solution, and isolating the objective compound under the condition necessary for the selective crystallization.
CONSTITUTION: β-Chloroalanine is prepared by reacting an aziridine-2-carboxylic acid salt with HCl. The reaction is carried out in an aqueous solution using 2.0W5.0mol, preferably 2.05W2.3mol, based on 1mol of the aziridine-2-carboxylic acid salt, of HCl (concentrated hydrochloric acid), and the objective compound is isolated under the condition necessary for the selective crystallization of the compound (the total concentration of the β- and α-chloro-β-alanine in the reaction solution is adjusted: the reaction temperature is -30W+40°C, preferably -20W+30°C). The objective compound can be separated directly from the reaction solution in the form of crystal without using a large excess HCl, and is easily separated from the by-products to obtain pure objective compound.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7352181A JPS57188548A (en) | 1981-05-18 | 1981-05-18 | Preparation of beta-chloroalanine |
US06/459,634 US4484003A (en) | 1981-05-18 | 1982-05-17 | Preparation process of β-chloroalanine |
DE8282901437T DE3267381D1 (en) | 1981-05-18 | 1982-05-17 | Process for preparing beta-chloroalanine |
PCT/JP1982/000174 WO1982004043A1 (en) | 1981-05-18 | 1982-05-17 | Process for preparing beta-chloroalanine |
EP82901437A EP0078853B1 (en) | 1981-05-18 | 1982-05-17 | Process for preparing beta-chloroalanine |
AU83960/82A AU548497B2 (en) | 1981-01-28 | 1982-05-17 | Process for preparing b-chloroalanine |
IT21318/82A IT1151407B (en) | 1981-05-18 | 1982-05-17 | BETA-CHLOROALANINE PREPARATION PROCESS |
MX192741A MX158197A (en) | 1981-05-18 | 1982-05-18 | CONTINUOUS PROCEDURE FOR OBTAINING BETA CLORDALANINE |
KR8202154A KR860001900B1 (en) | 1981-05-18 | 1982-05-18 | A process for preparing-chloroalanine |
CA000403196A CA1183869A (en) | 1981-05-18 | 1982-05-18 | PREPARATION PROCESS OF .beta.-CHLOROALANINE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7352181A JPS57188548A (en) | 1981-05-18 | 1981-05-18 | Preparation of beta-chloroalanine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57188548A true JPS57188548A (en) | 1982-11-19 |
JPS649309B2 JPS649309B2 (en) | 1989-02-16 |
Family
ID=13520621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7352181A Granted JPS57188548A (en) | 1981-01-28 | 1981-05-18 | Preparation of beta-chloroalanine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57188548A (en) |
-
1981
- 1981-05-18 JP JP7352181A patent/JPS57188548A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS649309B2 (en) | 1989-02-16 |
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