JPS5686172A - Preparation of uracil - Google Patents
Preparation of uracilInfo
- Publication number
- JPS5686172A JPS5686172A JP16330579A JP16330579A JPS5686172A JP S5686172 A JPS5686172 A JP S5686172A JP 16330579 A JP16330579 A JP 16330579A JP 16330579 A JP16330579 A JP 16330579A JP S5686172 A JPS5686172 A JP S5686172A
- Authority
- JP
- Japan
- Prior art keywords
- catalyst
- reaction
- acid
- cyanoacetylurea
- catalytically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To improve the purity and yield of the titled substance useful as a synthetic intermediate for medicines, without forming by-products, by reducing cyanoacetylurea catalytically and rapidly in the presence of a strong acid and a very small amount of catalyst.
CONSTITUTION: Cyanoacetylurea is catalytically reduced in the presence of a strong acid, e.g. hydrochloric or sulfuric acid, at 20W70°C, and then the temperature is preferably increased to complete the ring closure reaction and give the titled compound. In the reaction, an acid-resistant catalyst, e.g. the palladium or platinum type, is preferably used as the reduction catalyst. For example, the amount of the catalyst is about 1/50 of the raw material cyanoacelylurea in the case of 5% palladium carbon powder, and the reaction is completed at room temperature in a short time.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16330579A JPS5686172A (en) | 1979-12-15 | 1979-12-15 | Preparation of uracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16330579A JPS5686172A (en) | 1979-12-15 | 1979-12-15 | Preparation of uracil |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5686172A true JPS5686172A (en) | 1981-07-13 |
JPS6112906B2 JPS6112906B2 (en) | 1986-04-10 |
Family
ID=15771295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16330579A Granted JPS5686172A (en) | 1979-12-15 | 1979-12-15 | Preparation of uracil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5686172A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58172376A (en) * | 1982-04-02 | 1983-10-11 | Yodogawa Seiyaku Kk | Preparation of 5-ethyluracil |
US4440928A (en) * | 1981-09-01 | 1984-04-03 | Ube Industries, Ltd. | Process for preparation of uracils |
-
1979
- 1979-12-15 JP JP16330579A patent/JPS5686172A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4440928A (en) * | 1981-09-01 | 1984-04-03 | Ube Industries, Ltd. | Process for preparation of uracils |
JPS58172376A (en) * | 1982-04-02 | 1983-10-11 | Yodogawa Seiyaku Kk | Preparation of 5-ethyluracil |
Also Published As
Publication number | Publication date |
---|---|
JPS6112906B2 (en) | 1986-04-10 |
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