JPS56150039A - Clathrate compound of prostacycline derivative - Google Patents

Clathrate compound of prostacycline derivative

Info

Publication number
JPS56150039A
JPS56150039A JP5305680A JP5305680A JPS56150039A JP S56150039 A JPS56150039 A JP S56150039A JP 5305680 A JP5305680 A JP 5305680A JP 5305680 A JP5305680 A JP 5305680A JP S56150039 A JPS56150039 A JP S56150039A
Authority
JP
Japan
Prior art keywords
derivative
clathrate compound
alkyl
cyclodextrin
prostacycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5305680A
Other languages
Japanese (ja)
Inventor
Koichi Kojima
Kazu Tajima
Kiyoshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP5305680A priority Critical patent/JPS56150039A/en
Publication of JPS56150039A publication Critical patent/JPS56150039A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A clathrate compound obtained by the inclusion of 9(0)-methanoprostacycline derivative of formula [X is (CH2)n, (CH2)n-CH=CH (n is 0W7), or (CH2)p-A-(CH2)q (p and q are 1W4; A is O, S, or NH); Y is ethylene or trans- vinylene; R1 is H, alkyl, or salt-forming group; R2 and R3 are H or OH-protecting group; R4 is H or alkyl; R5 is alkyl, alkenyl, or alkynyl] is cyclodextrin.
EXAMPLE: 20-Methyl-9(0)-methanoprostacyclone β-cyclodextrin clathrate compound.
USE: Drug having blood platelet coagulation inhibiting activity. In is pharmaceutically and pharmacologically stable.
PROCESS: The objective compound is prepared, e.g. by mixing an alcohol solution of 9(0)-methanoprostacycline derivative and an aqueous solution of cyclodextrin at about 50W70°C under agitation or shaking.
COPYRIGHT: (C)1981,JPO&Japio
JP5305680A 1980-04-22 1980-04-22 Clathrate compound of prostacycline derivative Pending JPS56150039A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5305680A JPS56150039A (en) 1980-04-22 1980-04-22 Clathrate compound of prostacycline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5305680A JPS56150039A (en) 1980-04-22 1980-04-22 Clathrate compound of prostacycline derivative

Publications (1)

Publication Number Publication Date
JPS56150039A true JPS56150039A (en) 1981-11-20

Family

ID=12932189

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5305680A Pending JPS56150039A (en) 1980-04-22 1980-04-22 Clathrate compound of prostacycline derivative

Country Status (1)

Country Link
JP (1) JPS56150039A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2573422A1 (en) * 1984-11-22 1986-05-23 May & Baker Ltd NOVEL ANALOGUES OF PROSTAGLANDINS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1987005294A1 (en) * 1986-03-07 1987-09-11 Schering Aktiengesellschaft Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs
US4764528A (en) * 1986-03-17 1988-08-16 Teruo Kabushiki Kaisha 2,4-pentadienoic acid derivatives and platelet aggregation inhibitors containing the same
US5010065A (en) * 1987-11-27 1991-04-23 Schering Aktiengesellschaft Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use as pharmaceutical agents
US5221695A (en) * 1987-12-22 1993-06-22 Glaxo Group Limited Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin
JP2002518475A (en) * 1998-06-22 2002-06-25 シエーリング アクチエンゲゼルシヤフト Antioxidant measures in prostane derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130543A (en) * 1978-03-31 1979-10-09 Ono Pharmaceut Co Ltd Prostagladin i2 analog, and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130543A (en) * 1978-03-31 1979-10-09 Ono Pharmaceut Co Ltd Prostagladin i2 analog, and its preparation

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2573422A1 (en) * 1984-11-22 1986-05-23 May & Baker Ltd NOVEL ANALOGUES OF PROSTAGLANDINS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1987005294A1 (en) * 1986-03-07 1987-09-11 Schering Aktiengesellschaft Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs
GB2189783A (en) * 1986-03-07 1987-11-04 Schering Ag Carbacyclin-cyclodextrin compositions
GB2199031A (en) * 1986-03-07 1988-06-29 Schering Ag Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs
US4886788A (en) * 1986-03-07 1989-12-12 Schering Aktiengesellschaft Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents
GB2199031B (en) * 1986-03-07 1990-01-10 Schering Ag Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs
AU609390B2 (en) * 1986-03-07 1991-05-02 Schering Aktiengesellschaft Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs
JPH07107020B2 (en) * 1986-03-07 1995-11-15 シエ−リング アクチエンゲゼルシヤフト Cyclodextrin clathrates of carbacyclin derivatives
US4764528A (en) * 1986-03-17 1988-08-16 Teruo Kabushiki Kaisha 2,4-pentadienoic acid derivatives and platelet aggregation inhibitors containing the same
US5010065A (en) * 1987-11-27 1991-04-23 Schering Aktiengesellschaft Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use as pharmaceutical agents
US5221695A (en) * 1987-12-22 1993-06-22 Glaxo Group Limited Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin
JP2002518475A (en) * 1998-06-22 2002-06-25 シエーリング アクチエンゲゼルシヤフト Antioxidant measures in prostane derivatives

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