IE37392L - 5-amino-isophthalic acid derivatives - Google Patents

5-amino-isophthalic acid derivatives

Info

Publication number
IE37392L
IE37392L IE721238A IE123872A IE37392L IE 37392 L IE37392 L IE 37392L IE 721238 A IE721238 A IE 721238A IE 123872 A IE123872 A IE 123872A IE 37392 L IE37392 L IE 37392L
Authority
IE
Ireland
Prior art keywords
diethyl
anilino
nitro
amino
benzylamino
Prior art date
Application number
IE721238A
Other versions
IE37392B1 (en
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of IE37392L publication Critical patent/IE37392L/en
Publication of IE37392B1 publication Critical patent/IE37392B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Abstract

1380065 5-Aminoisophthalic acid derivatives LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB 28 Sept 1972 [5 Oct 1971 14 Dec 1971] 46291/71 Heading C2C [Also in Division A5] Novel therapeutic compounds (I) (including salts and esters thereof) in which X, is -O-, -S-, or -NH-; R 1 is hydrogen or an aliphatic radical with from one to four carbon atoms; R 2 and R 3 are hydrogen or a saturated or unsaturated, straight or branched optionally substituted aliphatic radical with from one to six carbon atoms, or an aryl- or heterocyclic-substituted aliphatic radical with from one to four carbon atoms; and R 4 is an unsubstituted or substituted phenyl radical; are made by standard methods. The invention also comprises novel-3-benzylamino-5-ethoxy-carbonyl - 4 - (phenory-, -phenylthio- and -pchlorophenylthio)-benzoic acids. Compounds (IV) and (V), where COOE signifies an ester or free carboxy group, are also prepared as well as 4-chloro-5-nitroisophthalic acid and its diethyl ester, diethyl 4 - anilino - 5 - nitroisophthalate, ethyl - 4- anilino - 5 - carboxy - 3 - nitrobenzoate and its potassium salt, ethyl 4-anilino-5-chlorocarbonyl-3- nitrobenzoate, 4 - anilino - 5 - carbamoyl - 3- nitrobenzoic acid, 4-anilino-5-nitro-isophthalic acid, ethyl 4-anilino-5-carboxy-3-nitrobenzoate, 5-amino- and 5-nitro-4-phenylthio-isophthalic acids, diethyl 3-benzylamino-4-phenylthioisophthalate, 4 - p - chlorophenylthio - 5 - amino and -nitro - isophthalic acids, diethyl 5 - benzylamino- 4-(p-chlorophenylthio)-isophthalate, diethyl 5- nitro and -amino-4-phenoxyisophthalates diethyl 5-benzylamino-4-phenoxyisophthalate and diethyl 5-amino- and 5-nitro-4-p-tolyloxyisophthalates [GB1380065A]
IE1238/72A 1971-10-05 1972-09-12 5-amino-isophthalic acid derivatives IE37392B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4629171A GB1380065A (en) 1971-10-05 1971-10-05 5-amino-isophthalic acid derivatives
GB5810071 1971-12-14

Publications (2)

Publication Number Publication Date
IE37392L true IE37392L (en) 1973-04-05
IE37392B1 IE37392B1 (en) 1977-07-20

Family

ID=26265784

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1238/72A IE37392B1 (en) 1971-10-05 1972-09-12 5-amino-isophthalic acid derivatives

Country Status (11)

Country Link
US (1) US3864385A (en)
JP (1) JPS4844229A (en)
BE (1) BE789679A (en)
CA (1) CA1002964A (en)
DE (1) DE2248596A1 (en)
FR (1) FR2158208B1 (en)
GB (1) GB1380065A (en)
IE (1) IE37392B1 (en)
LU (1) LU66227A1 (en)
NL (1) NL7213059A (en)
SE (1) SE400551B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50102767A (en) * 1974-01-22 1975-08-14
US4204970A (en) * 1978-12-07 1980-05-27 Standard Oil Company (Indiana) Lubricant compositions containing alkylated aromatic amino acid antioxidants
JPS62192494A (en) * 1986-02-20 1987-08-24 Echiren Chem Kk Hydraulic fluid composition for use in hydraulic brake of automobile
MX18467A (en) * 1988-11-23 1993-07-01 Pfizer THERAPEUTIC AGENTS OF QUINUCLIDINES
US7781596B1 (en) * 1998-11-03 2010-08-24 Abbott Laboratories Substituted 2-phenylbenzimidazoles, the production thereof and their use
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
DE602006013191D1 (en) * 2005-11-15 2010-05-06 Abbott Lab SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXYLIC ACIDS ARE EFFECTIVE PARP INHIBITORS
US20070259937A1 (en) * 2006-05-02 2007-11-08 Giranda Vincent L Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
WO2010083199A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252959B (en) * 1964-12-31 1967-10-26 Bayer Ag Acaricidal agents

Also Published As

Publication number Publication date
GB1380065A (en) 1975-01-08
JPS4844229A (en) 1973-06-26
FR2158208A1 (en) 1973-06-15
NL7213059A (en) 1973-04-09
CA1002964A (en) 1977-01-04
BE789679A (en) 1973-04-04
DE2248596A1 (en) 1973-04-12
IE37392B1 (en) 1977-07-20
LU66227A1 (en) 1973-01-23
FR2158208B1 (en) 1975-08-08
US3864385A (en) 1975-02-04
SE400551B (en) 1978-04-03

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