GB1380065A - 5-amino-isophthalic acid derivatives - Google Patents

5-amino-isophthalic acid derivatives

Info

Publication number
GB1380065A
GB1380065A GB4629171A GB4629171A GB1380065A GB 1380065 A GB1380065 A GB 1380065A GB 4629171 A GB4629171 A GB 4629171A GB 4629171 A GB4629171 A GB 4629171A GB 1380065 A GB1380065 A GB 1380065A
Authority
GB
United Kingdom
Prior art keywords
diethyl
anilino
nitro
amino
benzylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4629171A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE789679D priority Critical patent/BE789679A/en
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Priority to GB4629171A priority patent/GB1380065A/en
Priority to IE1238/72A priority patent/IE37392B1/en
Priority to ZA726390A priority patent/ZA726390B/en
Priority to AU47031/72A priority patent/AU466298B2/en
Priority to CA152,555A priority patent/CA1002964A/en
Priority to US292525A priority patent/US3864385A/en
Priority to NL7213059A priority patent/NL7213059A/xx
Priority to LU66227A priority patent/LU66227A1/xx
Priority to FR7235179A priority patent/FR2158208B1/fr
Priority to DE19722248596 priority patent/DE2248596A1/en
Priority to JP47099744A priority patent/JPS4844229A/ja
Priority to SE7212799A priority patent/SE400551B/en
Publication of GB1380065A publication Critical patent/GB1380065A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

1380065 5-Aminoisophthalic acid derivatives LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB 28 Sept 1972 [5 Oct 1971 14 Dec 1971] 46291/71 Heading C2C [Also in Division A5] Novel therapeutic compounds (I) (including salts and esters thereof) in which X, is -O-, -S-, or -NH-; R 1 is hydrogen or an aliphatic radical with from one to four carbon atoms; R 2 and R 3 are hydrogen or a saturated or unsaturated, straight or branched optionally substituted aliphatic radical with from one to six carbon atoms, or an aryl- or heterocyclic-substituted aliphatic radical with from one to four carbon atoms; and R 4 is an unsubstituted or substituted phenyl radical; are made by standard methods. The invention also comprises novel-3-benzylamino-5-ethoxy-carbonyl - 4 - (phenory-, -phenylthio- and -pchlorophenylthio)-benzoic acids. Compounds (IV) and (V), where COOE signifies an ester or free carboxy group, are also prepared as well as 4-chloro-5-nitroisophthalic acid and its diethyl ester, diethyl 4 - anilino - 5 - nitroisophthalate, ethyl - 4- anilino - 5 - carboxy - 3 - nitrobenzoate and its potassium salt, ethyl 4-anilino-5-chlorocarbonyl-3- nitrobenzoate, 4 - anilino - 5 - carbamoyl - 3- nitrobenzoic acid, 4-anilino-5-nitro-isophthalic acid, ethyl 4-anilino-5-carboxy-3-nitrobenzoate, 5-amino- and 5-nitro-4-phenylthio-isophthalic acids, diethyl 3-benzylamino-4-phenylthioisophthalate, 4 - p - chlorophenylthio - 5 - amino and -nitro - isophthalic acids, diethyl 5 - benzylamino- 4-(p-chlorophenylthio)-isophthalate, diethyl 5- nitro and -amino-4-phenoxyisophthalates diethyl 5-benzylamino-4-phenoxyisophthalate and diethyl 5-amino- and 5-nitro-4-p-tolyloxyisophthalates
GB4629171A 1971-10-05 1971-10-05 5-amino-isophthalic acid derivatives Expired GB1380065A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
BE789679D BE789679A (en) 1971-10-05 NEW DERIVATIVES OF 5-AMINO ISOPHTHALIC ACID AND THEIR PREPARATION PROCEDURES
GB4629171A GB1380065A (en) 1971-10-05 1971-10-05 5-amino-isophthalic acid derivatives
IE1238/72A IE37392B1 (en) 1971-10-05 1972-09-12 5-amino-isophthalic acid derivatives
ZA726390A ZA726390B (en) 1971-10-05 1972-09-19 New 5-aminoisophthauc acid(3-amino-5-carboxybenzoic acid),to salts and esters of these compounds and to methods for their preparation
AU47031/72A AU466298B2 (en) 1971-10-05 1972-09-25 Derivatives of 5-amino isophthalic acid and salts and esters thereof
CA152,555A CA1002964A (en) 1971-10-05 1972-09-26 Methods for producing new diuretics
NL7213059A NL7213059A (en) 1971-10-05 1972-09-27
US292525A US3864385A (en) 1971-10-05 1972-09-27 New 5-Aminoisophthalic Acid Derivatives, Salts And Esters Thereof And Methods For Their Preparation
LU66227A LU66227A1 (en) 1971-10-05 1972-10-03
FR7235179A FR2158208B1 (en) 1971-10-05 1972-10-04
DE19722248596 DE2248596A1 (en) 1971-10-05 1972-10-04 NEW DERIVATIVES OF AMINOISOPHTALIC ACID
JP47099744A JPS4844229A (en) 1971-10-05 1972-10-04
SE7212799A SE400551B (en) 1971-10-05 1972-10-04 PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 3-AMINO-5-CARBAMYLBENZOIC ACID DERIVATIVES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4629171A GB1380065A (en) 1971-10-05 1971-10-05 5-amino-isophthalic acid derivatives
GB5810071 1971-12-14

Publications (1)

Publication Number Publication Date
GB1380065A true GB1380065A (en) 1975-01-08

Family

ID=26265784

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4629171A Expired GB1380065A (en) 1971-10-05 1971-10-05 5-amino-isophthalic acid derivatives

Country Status (11)

Country Link
US (1) US3864385A (en)
JP (1) JPS4844229A (en)
BE (1) BE789679A (en)
CA (1) CA1002964A (en)
DE (1) DE2248596A1 (en)
FR (1) FR2158208B1 (en)
GB (1) GB1380065A (en)
IE (1) IE37392B1 (en)
LU (1) LU66227A1 (en)
NL (1) NL7213059A (en)
SE (1) SE400551B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204970A (en) * 1978-12-07 1980-05-27 Standard Oil Company (Indiana) Lubricant compositions containing alkylated aromatic amino acid antioxidants

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50102767A (en) * 1974-01-22 1975-08-14
JPS62192494A (en) * 1986-02-20 1987-08-24 Echiren Chem Kk Hydraulic fluid composition for use in hydraulic brake of automobile
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
JP2002528531A (en) 1998-11-03 2002-09-03 ビーエーエスエフ アクチェンゲゼルシャフト Substituted 2-phenylbenzimidazoles, their preparation and use
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
DE602006013191D1 (en) * 2005-11-15 2010-05-06 Abbott Lab SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXYLIC ACIDS ARE EFFECTIVE PARP INHIBITORS
EP2012780B1 (en) * 2006-05-02 2012-04-11 Abbott Laboratories Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
WO2010083199A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252959B (en) * 1964-12-31 1967-10-26 Bayer Ag Acaricidal agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204970A (en) * 1978-12-07 1980-05-27 Standard Oil Company (Indiana) Lubricant compositions containing alkylated aromatic amino acid antioxidants

Also Published As

Publication number Publication date
NL7213059A (en) 1973-04-09
US3864385A (en) 1975-02-04
SE400551B (en) 1978-04-03
JPS4844229A (en) 1973-06-26
DE2248596A1 (en) 1973-04-12
FR2158208B1 (en) 1975-08-08
IE37392B1 (en) 1977-07-20
LU66227A1 (en) 1973-01-23
IE37392L (en) 1973-04-05
FR2158208A1 (en) 1973-06-15
CA1002964A (en) 1977-01-04
BE789679A (en) 1973-04-04

Similar Documents

Publication Publication Date Title
GB1380065A (en) 5-amino-isophthalic acid derivatives
GB1363847A (en) Iodinated organic acid derivatives for use as x-ray contrast agents
IE781227L (en) New peptide derivatives.
GB1430838A (en) 7beta-amino-cepham-3-one-4-carboxylic acid compounds and process for their manufacture
GB1448316A (en) Racemization of optically active 2,2-dimethyl-3,1,-alkenyl- cyclopropane-1-carboxylic acids
GB1496492A (en) Optically active lysergic acid derivatives
GB1432503A (en) Cycloalkylalkylesters and process for their preparation
GB1496692A (en) Process for the preparation of ceph-2-em compounds
GB1298005A (en)
GB1453376A (en) Naphthalene carboxylic acids and derivatives thereof
ES421098A1 (en) Fluoro-substituted thiaxanthene derivatives
GB1203538A (en) Cubane derivatives
GB1515614A (en) Preparation of m-benzoylhydratropic acid and an intermediate therefor
ES385183A1 (en) Beta-(2,4,6-triiodo-3-acetamidinophenyl)-propionic acids
ES446623A1 (en) Steroid carboxylic acids and derivatives
GB1364870A (en) Ethylene polymerization
ES430900A1 (en) Substituted indanones
GB1284423A (en) Cyclohexa-1,4-diene-1-acetic acids
GB1144829A (en) Tricyclic derivatives of acetamide
GB1315564A (en) Nickel salts of phosphonic acid monoesters
ES430901A1 (en) Substituted indanyl -oxy and thio- alkanoic acids and their derivatives
JPS52106857A (en) Preparation of 1,3-disubstituted-2-azetidinones
GB1236355A (en) Cyclopropanecarboxylic acid esters
GB1292662A (en) Bicycloheptaneheptanoic acids and esters thereof
GB1465497A (en) Flupen-thixol ester

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee