ES479732A1 - Procedimiento para la obtencion de antibioticos de b-lactamasemi-sin-teticos. - Google Patents

Procedimiento para la obtencion de antibioticos de b-lactamasemi-sin-teticos.

Info

Publication number
ES479732A1
ES479732A1 ES479732A ES479732A ES479732A1 ES 479732 A1 ES479732 A1 ES 479732A1 ES 479732 A ES479732 A ES 479732A ES 479732 A ES479732 A ES 479732A ES 479732 A1 ES479732 A1 ES 479732A1
Authority
ES
Spain
Prior art keywords
beta
carboxylic acid
reaction
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479732A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6037546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES479732(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES479732A1 publication Critical patent/ES479732A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la obtención de antibióticos de beta-lactama semi-sintéticos de compuestos amino de fórmula**fórmula** donde X significa los miembros restantes de una anillo usual en un antibiótico de beta- lactama y R significa hidrógeno o metoxi, y derivados activados de ácido carboxílico de fórmula **fórmula** donde R1 significa u resto orgánico , B significa Fenilo, en caso dado sustituido, ciclohexadienilo o heterociclilo y R2 significa un resto alquilo inferior, caracterizado porque los compuestos (i) y (II) se hacen reaccionar en una mezcla de acetona-agua que contiene la acetona y el agua en una proporción de 0,5:1 hasta 3:1
ES479732A 1978-04-20 1979-04-19 Procedimiento para la obtencion de antibioticos de b-lactamasemi-sin-teticos. Expired ES479732A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782817228 DE2817228A1 (de) 1978-04-20 1978-04-20 Verfahren zur herstellung halbsynthetischer beta-lactamantibiotika

Publications (1)

Publication Number Publication Date
ES479732A1 true ES479732A1 (es) 1980-01-16

Family

ID=6037546

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479732A Expired ES479732A1 (es) 1978-04-20 1979-04-19 Procedimiento para la obtencion de antibioticos de b-lactamasemi-sin-teticos.

Country Status (7)

Country Link
US (1) US4229349A (es)
EP (1) EP0004938B1 (es)
JP (1) JPS54145693A (es)
AT (1) AT369004B (es)
DE (2) DE2817228A1 (es)
ES (1) ES479732A1 (es)
IL (1) IL57084A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221200B1 (en) * 1990-01-22 2002-08-28 Biochemie Gmbh Process for producing beta-lactames
CN101328187B (zh) * 2007-06-20 2011-05-25 瑞阳制药有限公司 美洛西林的制备工艺
CN101550144B (zh) * 2009-05-22 2011-05-11 山东润泽制药有限公司 美洛西林酸的制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864329A (en) * 1970-12-29 1975-02-04 Sumitomo Chemical Co Penicillins substituted with heterocyclic groups
BE790441A (fr) * 1971-10-23 1973-04-24 Bayer Ag Nouvelles penicillines, leur procede de preparation et medicament les contenant
JPS5318515B2 (es) * 1971-12-17 1978-06-15
AR208171A1 (es) * 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico
US4039673A (en) * 1973-10-30 1977-08-02 Bayer Aktiengesellschaft Penicillins and cephalosporins and their production
IL47168A (en) * 1974-05-09 1979-07-25 Toyama Chemical Co Ltd Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same
US4087424A (en) * 1974-05-09 1978-05-02 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
JPS5852996B2 (ja) * 1975-03-25 1983-11-26 バイエル・アクチエンゲゼルシヤフト β−ラクタム及び抗バクテリア剤
US4053609A (en) * 1975-09-12 1977-10-11 Tanabe Seiyaku Co., Ltd. Penicillins and processes for preparing the same
DE2613172A1 (de) * 1976-03-27 1977-10-06 Bayer Ag Verfahren zur herstellung von penicillinen und cephalosporinen
JPS5321190A (en) * 1976-08-10 1978-02-27 Baiokurafuto Lab Inc Production of 66 aminopenicillanic acid derivative

Also Published As

Publication number Publication date
EP0004938B1 (de) 1981-06-03
AT369004B (de) 1982-11-25
EP0004938A1 (de) 1979-10-31
IL57084A (en) 1982-07-30
JPS54145693A (en) 1979-11-14
US4229349A (en) 1980-10-21
DE2817228A1 (de) 1979-10-31
IL57084A0 (en) 1979-07-25
DE2960388D1 (en) 1981-09-10
ATA290179A (de) 1982-04-15

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