GB1382169A - Alpha-phosphonoacetylcephalosporins - Google Patents
Alpha-phosphonoacetylcephalosporinsInfo
- Publication number
- GB1382169A GB1382169A GB775572A GB775572A GB1382169A GB 1382169 A GB1382169 A GB 1382169A GB 775572 A GB775572 A GB 775572A GB 775572 A GB775572 A GB 775572A GB 1382169 A GB1382169 A GB 1382169A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aralkyl
- alkyl
- carbocyclic aryl
- carbon
- monocyclic carbocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- XOAOLUVHGLODKG-UHFFFAOYSA-N 2-phenyl-2-phosphonoacetic acid Chemical compound OC(=O)C(P(O)(O)=O)C1=CC=CC=C1 XOAOLUVHGLODKG-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000005333 aroyloxy group Chemical group 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- AIPRAPZUGUTQKX-UHFFFAOYSA-N diethoxyphosphorylmethylbenzene Chemical compound CCOP(=O)(OCC)CC1=CC=CC=C1 AIPRAPZUGUTQKX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002596 lactones Chemical group 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1382169 Alpha-phosphonoacetylcephalosporins E R SQUIBB & SONS Inc 18 Feb 1972 [22 Feb 1971] 7755/72 Heading C2P Compounds of the formula (where R is H, C 1 -C 8 alkyl, aralkyl, CH 2 - OCOR 4 , or a salt forming ion; R 1 is H, lower alkyl. Monocyclic carbocyclic aryl or aralkyl, or a monocyclic heterocyclic group containing 5 or 6- members in the ring consisting of carbon, oxygen, nitrogen and sulphur, no-more than two being other than carbon, R 2 and R 3 each is H, metal ion, amine salt ion, C 1 -C 8 alkyl or monocyclic carbocyclic aryl or aralkyl: R 4 is C 1 -C 8 alkyl, monocyclic carbocyclic aryl or aralkyl and X is H, OH, lower alkanoyloxy, aroyloxy, aralkanoyloxy, the radical of a nitrogen base, quaternary ammonium radical or together X and R form a bond linking carbon and oxygen in a lactone ring) and prepared by reacting a compound with a compound or an acylating derivative thereof. Benzyl phosphonic acid diethyl ester, α-phosphonophenylacetic acid, P,P-diethyl and -dibenzyl esters, P-monoethyl and -monobenzyl esters and α-phosphonophenylacetic acid are prepared as intermediates. Pharmaceutical cleaning and disinfecting compositions comprise compounds (I) and a diluent. Antibacterial compositions may be administered orally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11777971A | 1971-02-22 | 1971-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1382169A true GB1382169A (en) | 1975-01-29 |
Family
ID=22374762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB775572A Expired GB1382169A (en) | 1971-02-22 | 1972-02-18 | Alpha-phosphonoacetylcephalosporins |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH539078A (en) |
| DE (1) | DE2208273A1 (en) |
| FR (1) | FR2126304B1 (en) |
| GB (1) | GB1382169A (en) |
| HU (1) | HU163354B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0018155A2 (en) * | 1979-04-09 | 1980-10-29 | Novo Nordisk A/S | Novel cephalosporin compounds, a process for the preparation thereof, pharmaceutical compositions containing the same and the use thereof as a therapeutic agent against a microorganism |
| GB2141124A (en) * | 1983-05-17 | 1984-12-12 | Chinoin Gyogyszer Es Vegyeszet | Phosphorus containing semisynthetic cephalosporanic and penicillanic derivatives |
-
1972
- 1972-02-18 GB GB775572A patent/GB1382169A/en not_active Expired
- 1972-02-22 FR FR7205967A patent/FR2126304B1/fr not_active Expired
- 1972-02-22 HU HUSU000719 patent/HU163354B/hu unknown
- 1972-02-22 DE DE19722208273 patent/DE2208273A1/en active Pending
- 1972-02-22 CH CH252772A patent/CH539078A/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0018155A2 (en) * | 1979-04-09 | 1980-10-29 | Novo Nordisk A/S | Novel cephalosporin compounds, a process for the preparation thereof, pharmaceutical compositions containing the same and the use thereof as a therapeutic agent against a microorganism |
| EP0018155A3 (en) * | 1979-04-09 | 1981-05-13 | Novo Nordisk A/S | Novel cephalosporin compounds, a process for the preparation thereof, pharmaceutical compositions containing the same and the use thereof as a therapeutic agent against a microorganism |
| GB2141124A (en) * | 1983-05-17 | 1984-12-12 | Chinoin Gyogyszer Es Vegyeszet | Phosphorus containing semisynthetic cephalosporanic and penicillanic derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2126304A1 (en) | 1972-10-06 |
| DE2208273A1 (en) | 1972-09-21 |
| HU163354B (en) | 1973-07-28 |
| CH539078A (en) | 1973-07-15 |
| FR2126304B1 (en) | 1975-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |