GB1410853A - Pharmaceutically useful prostaglandin derivatives - Google Patents
Pharmaceutically useful prostaglandin derivativesInfo
- Publication number
- GB1410853A GB1410853A GB4017573A GB4017573A GB1410853A GB 1410853 A GB1410853 A GB 1410853A GB 4017573 A GB4017573 A GB 4017573A GB 4017573 A GB4017573 A GB 4017573A GB 1410853 A GB1410853 A GB 1410853A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- alkyl
- prepared
- compound
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002196 ecbolic effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052987 metal hydride Inorganic materials 0.000 abstract 1
- 150000004681 metal hydrides Chemical class 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1410853 Prostaglandins SANKYO CO Ltd 24 Aug 1973 [1 Sept 1972] 40175/73 Heading C2C Novel compounds of Formula I in which A=C 4-8 alkylene, R<SP>1</SP>= C 4-10 alkyl, R<SP>2</SP>=H or C 1-6 alkyl and R<SP>3</SP>=H or C 1-6 alkoxycarbonyl, and pharmaceutically acceptable acid addition salts thereof, are prepared by reducing a compound of Formula II, II or IV with a metal hydride complex reducing agent and, if appropriate, salifying the product obtained. Compounds I in which both R<SP>2</SP> and R<SP>3</SP> are H can also be prepared by hydrolysis of a compound I in which R<SP>2</SP>=alkyl and/or R<SP>3</SP>= alkoxycarbonyl. The corresponding groups can also be removed from compounds II, III and IV, to give compounds in which R<SP>2</SP> and R<SP>3</SP> are H. Starting materials of Formulae II and IV and intermediates therefor are prepared by the following reaction schemes Pharmaceutical compositions having oxytocic activity, for parenteral administration, comprise a compound I, or a pharmaceutically acceptable salt thereof, together with a pharmaceutical carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47088171A JPS5146113B2 (en) | 1972-09-01 | 1972-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1410853A true GB1410853A (en) | 1975-10-22 |
Family
ID=13935457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4017573A Expired GB1410853A (en) | 1972-09-01 | 1973-08-24 | Pharmaceutically useful prostaglandin derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3899525A (en) |
| JP (1) | JPS5146113B2 (en) |
| BE (1) | BE804342A (en) |
| CH (1) | CH578495A5 (en) |
| DE (1) | DE2344058A1 (en) |
| FR (1) | FR2197591B1 (en) |
| GB (1) | GB1410853A (en) |
| NL (1) | NL7312143A (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE384853B (en) * | 1972-04-04 | 1976-05-24 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF NEW AMINES |
| US3992411A (en) * | 1974-01-23 | 1976-11-16 | Merck & Co., Inc. | 2α-Formyl-3β-[(methoxalyl)oxy]-5-oxo-1β-cyclopentaneheptanoic acid and process |
| US3992412A (en) * | 1974-01-23 | 1976-11-16 | Merck & Co., Inc. | 2α-(2-Carboxy-2-oxoethyl)-3β-hydroxy-5-oxo-1β-cyclopentaneheptanoic acid and process |
| US4005106A (en) * | 1974-01-23 | 1977-01-25 | Merck & Co., Inc. | 3β-[(Methoxalyl)oxy]-2α-(3-oxo-1-octenyl)-5-oxo-1β-cyclopentaneheptanoic acid and process |
| US3991083A (en) * | 1974-01-23 | 1976-11-09 | Merck & Co., Inc. | 2α-(2-Loweralkanoyloxy-2-carboxyvinyl)-3β-hydroxy-5-oxo-1β-c |
| US3998849A (en) * | 1974-01-23 | 1976-12-21 | Merck & Co., Inc. | 2α-(2-Carboxy-2-formylethyl)-3β-hydroxy-5-oxo-β-cyclopentaneheptanoic acid and process |
| US3931282A (en) * | 1974-02-21 | 1976-01-06 | Syntex (U.S.A.) Inc. | 11α-Hydroxymethyl prostaglandins |
| US3996263A (en) * | 1975-05-05 | 1976-12-07 | Sankyo Company Limited | 9-Oxo-11α-methyl-15Ε-hyroxyprost-13(trans)-enoic acid derivatives and process for the preparaion thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455992A (en) * | 1966-05-10 | 1969-07-15 | American Home Prod | Process for preparing 11-desoxyprostaglandin and homologs thereof |
-
1972
- 1972-09-01 JP JP47088171A patent/JPS5146113B2/ja not_active Expired
-
1973
- 1973-08-24 GB GB4017573A patent/GB1410853A/en not_active Expired
- 1973-08-27 US US392113A patent/US3899525A/en not_active Expired - Lifetime
- 1973-08-28 FR FR7331132A patent/FR2197591B1/fr not_active Expired
- 1973-08-31 DE DE19732344058 patent/DE2344058A1/en active Pending
- 1973-08-31 BE BE135225A patent/BE804342A/en unknown
- 1973-08-31 CH CH1254173A patent/CH578495A5/xx not_active IP Right Cessation
- 1973-09-03 NL NL7312143A patent/NL7312143A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH578495A5 (en) | 1976-08-13 |
| FR2197591A1 (en) | 1974-03-29 |
| BE804342A (en) | 1974-02-28 |
| US3899525A (en) | 1975-08-12 |
| NL7312143A (en) | 1974-03-05 |
| DE2344058A1 (en) | 1974-03-07 |
| JPS5146113B2 (en) | 1976-12-07 |
| JPS4943947A (en) | 1974-04-25 |
| FR2197591B1 (en) | 1976-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |