GB1347665A - Process for the production of cephalexin - Google Patents
Process for the production of cephalexinInfo
- Publication number
- GB1347665A GB1347665A GB3858772A GB3858772A GB1347665A GB 1347665 A GB1347665 A GB 1347665A GB 3858772 A GB3858772 A GB 3858772A GB 3858772 A GB3858772 A GB 3858772A GB 1347665 A GB1347665 A GB 1347665A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenylglycine
- enzyme
- cellulose
- enzyme preparations
- nrrl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1347665 Preparation of cephalexin TOYO JOZO KK 18 Aug 1972 [20 Aug 1971 14 Jan 1972] 38587/72 Heading C2A Cephalexin (7 - (D - α - aminophenylacetamido) - desacetoxy cephalosporanic acid) is prepared by reacting 7-aminodesacetoxy-cephalosporanic acid with D-phenylglycine or a reactive derivative thereof such as D-phenylglycine methyl or ethyl ester, D-phenylglycine amide, and D-phenylglycyl-glycine, -leucine or -alanine, in an aqueous medium in the presence of acylating enzyme derived from a microorganism selected from the genera Alcaligenes, Achromobacter, Flavobacterium, Bacillus and Beneckea such as Alcaligenes faecalis ATCC 8750, Achromobacter Nov. Sp. B-402-2 NRRL B-5393, Flavobacterium aquatile NRRL B-5394, Bacillus megaterium NRRL B-5385, Beneckea hiperoptica ATCC 15803, Flavobacterium capsulatum ATCC 14666. The acylation may be carried out batchwise or in a column, at a temperature of 20-45‹ C., at a pH of 5À5-7À5, for 0À5 to 3 hours, with a 2-20 molar excess of the D-phenylglycine reaction component, referred to the 7-aminoacetocy-cephalosporanic acid. The acylating enzyme preparations may be in the form of culture broths, bacterial cells, treated bacterial cells, enzyme extracts, solid phase enzyme preparations or insoluble enzyme preparations of the micro-organisms. Insolubilized enzyme preparations comprise a culture broth of the micro-organism, microbial cells thereof or enzyme prepared therefrom, absorbed on a solid carrier such as diatomaceous earth, acid clay, active clay, alumina, kaolin, calcium phosphate, hydroxy apatite, CM - cellulose, DEAE-cellulose, TEAE-cellulose or carboxymethyl cross-linked dextran.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP46063715A JPS5231436B2 (en) | 1971-08-20 | 1971-08-20 | |
| JP640772A JPS552958B2 (en) | 1972-01-14 | 1972-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1347665A true GB1347665A (en) | 1974-02-20 |
Family
ID=26340537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3858772A Expired GB1347665A (en) | 1971-08-20 | 1972-08-18 | Process for the production of cephalexin |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT324548B (en) |
| AU (1) | AU445437B2 (en) |
| BE (1) | BE787793A (en) |
| CA (1) | CA986440A (en) |
| CH (1) | CH588496A5 (en) |
| DD (1) | DD101166A5 (en) |
| DE (1) | DE2241091B2 (en) |
| FR (1) | FR2150380B1 (en) |
| GB (1) | GB1347665A (en) |
| HU (1) | HU164997B (en) |
| NL (1) | NL7211406A (en) |
| SE (1) | SE404928B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5231035B2 (en) * | 1972-08-22 | 1977-08-12 | ||
| FR2440402B1 (en) * | 1978-10-30 | 1981-08-14 | Inst Nat Rech Chimique | METHOD FOR IMMOBILIZING MICRO-ORGANISMS AND APPLICATIONS THEREOF |
| IT1274658B (en) * | 1995-02-28 | 1997-07-18 | Acs Dobfar Spa | IMPROVED ENZYMATIC PROCEDURE FOR THE PRODUCTION OF PENICILLINS AND CEPHALOSPORINS |
-
1972
- 1972-08-18 GB GB3858772A patent/GB1347665A/en not_active Expired
- 1972-08-18 CA CA150,260A patent/CA986440A/en not_active Expired
- 1972-08-18 FR FR7229647A patent/FR2150380B1/fr not_active Expired
- 1972-08-18 HU HUTO000884 patent/HU164997B/hu unknown
- 1972-08-18 SE SE1072172A patent/SE404928B/en unknown
- 1972-08-19 CH CH1231972A patent/CH588496A5/xx not_active IP Right Cessation
- 1972-08-21 AT AT719272A patent/AT324548B/en not_active IP Right Cessation
- 1972-08-21 BE BE787793A patent/BE787793A/en unknown
- 1972-08-21 DE DE19722241091 patent/DE2241091B2/en active Granted
- 1972-08-21 NL NL7211406A patent/NL7211406A/xx not_active Application Discontinuation
- 1972-08-21 DD DD16516072A patent/DD101166A5/xx unknown
- 1972-08-21 AU AU45781/72A patent/AU445437B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE787793A (en) | 1972-12-18 |
| CA986440A (en) | 1976-03-30 |
| AU4578172A (en) | 1974-02-21 |
| HU164997B (en) | 1974-05-28 |
| NL7211406A (en) | 1973-02-22 |
| FR2150380A1 (en) | 1973-04-06 |
| AT324548B (en) | 1975-09-10 |
| FR2150380B1 (en) | 1974-10-04 |
| DE2241091B2 (en) | 1976-02-05 |
| DE2241091A1 (en) | 1973-03-15 |
| AU445437B2 (en) | 1974-02-21 |
| CH588496A5 (en) | 1977-06-15 |
| DD101166A5 (en) | 1973-10-20 |
| SE404928B (en) | 1978-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |