PT98205A - Processo para a preparacao de novos derivados beta-lactamicos - Google Patents

Processo para a preparacao de novos derivados beta-lactamicos

Info

Publication number
PT98205A
PT98205A PT98205A PT9820591A PT98205A PT 98205 A PT98205 A PT 98205A PT 98205 A PT98205 A PT 98205A PT 9820591 A PT9820591 A PT 9820591A PT 98205 A PT98205 A PT 98205A
Authority
PT
Portugal
Prior art keywords
derivatives
lactamic
beta
preparing new
new beta
Prior art date
Application number
PT98205A
Other languages
English (en)
Other versions
PT98205B (pt
Inventor
Svend Gunnar Kaasgaard
Ulla Veitland
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PT98205A publication Critical patent/PT98205A/pt
Publication of PT98205B publication Critical patent/PT98205B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT98205A 1990-07-04 1991-07-04 Processo para a preparacao de novos derivados beta-lactamicos PT98205B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90610045 1990-07-04

Publications (2)

Publication Number Publication Date
PT98205A true PT98205A (pt) 1992-05-29
PT98205B PT98205B (pt) 1998-12-31

Family

ID=8205872

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98205A PT98205B (pt) 1990-07-04 1991-07-04 Processo para a preparacao de novos derivados beta-lactamicos

Country Status (17)

Country Link
US (1) US5525483A (pt)
EP (1) EP0537255B1 (pt)
JP (1) JP3115593B2 (pt)
KR (1) KR100222606B1 (pt)
AT (1) ATE317912T1 (pt)
AU (1) AU8208691A (pt)
CA (1) CA2086250C (pt)
CZ (1) CZ381392A3 (pt)
DE (1) DE69133509T2 (pt)
ES (1) ES2258260T3 (pt)
FI (1) FI925988A0 (pt)
NO (1) NO307710B1 (pt)
PT (1) PT98205B (pt)
RU (1) RU2136759C1 (pt)
SK (1) SK381392A3 (pt)
WO (1) WO1992001061A1 (pt)
ZA (1) ZA915142B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK63894A3 (en) * 1991-12-19 1995-03-08 Novo Nordisk As Method of preparation of beta-lactam antibiotic
ZA932809B (en) * 1992-04-24 1994-10-21 Lilly Co Eli Process for preparing cephalosporins.
WO1994017800A1 (en) * 1993-02-15 1994-08-18 Gist-Brocades B.V. AN IMPROVED β-LACTAM ANTIBIOTIC COMPOSITION
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
JPH0719083U (ja) * 1993-09-20 1995-04-04 株式会社江崎製作所 自動二輪車のヘッドパイプ
AUPM543894A0 (en) * 1994-05-04 1994-05-26 Commonwealth Scientific And Industrial Research Organisation An adjuvant
ZA954839B (en) * 1994-06-10 1996-05-14 Gist Brocades Bv An acylation method
DE69512917D1 (de) * 1994-07-18 1999-11-25 Dsm Nv Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
DE69607778T2 (de) * 1995-02-28 2000-08-10 Acs Dobfar S.P.A., Tribiano Verfahren zur enzymatischen Synthese von beta-laktam Antibiotika in Anwesenheit von einem Enzyminhibitor
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
KR100455252B1 (ko) * 1995-12-08 2005-01-15 디에스엠 기스트 베.파우. 항생제제조방법
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) * 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
WO2007134987A1 (en) 2006-05-19 2007-11-29 Dsm Ip Assets B.V. Process for the crystallisation of cefadroxil
BRPI0808685A2 (pt) * 2007-03-09 2014-08-19 Dsm Ip Assets Bv Processo para a preparação de derivados semissintéticos de beta-lactama.
EP2723882B1 (en) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079305A (en) * 1959-09-24 1963-02-26 Bayer Ag Process for the enzymatic acylation of 6-aminopenicillanic acid
US3152050A (en) * 1962-12-27 1964-10-06 American Home Prod Enzymatic process for preparing penicillins
JPS5417030B2 (pt) * 1972-12-06 1979-06-27
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
ATE138690T1 (de) * 1988-04-26 1996-06-15 Gist Brocades Nv Verfahren zur enzymatischen herstellung von beta- lactamen
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

Also Published As

Publication number Publication date
NO930006L (no) 1993-01-04
JP3115593B2 (ja) 2000-12-11
FI925988A (fi) 1992-12-31
DE69133509T2 (de) 2006-08-24
DE69133509D1 (de) 2006-04-20
JPH05507623A (ja) 1993-11-04
RU2136759C1 (ru) 1999-09-10
CA2086250C (en) 2001-05-29
SK381392A3 (en) 1995-11-08
CZ381392A3 (en) 1993-12-15
NO307710B1 (no) 2000-05-15
ATE317912T1 (de) 2006-03-15
PT98205B (pt) 1998-12-31
CA2086250A1 (en) 1992-01-05
ES2258260T3 (es) 2006-08-16
AU8208691A (en) 1992-02-04
FI925988A0 (fi) 1992-12-31
KR100222606B1 (en) 1999-10-01
US5525483A (en) 1996-06-11
NO930006D0 (no) 1993-01-04
WO1992001061A1 (en) 1992-01-23
ZA915142B (en) 1992-05-27
EP0537255A1 (en) 1993-04-21
EP0537255B1 (en) 2006-02-15

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920106

FG3A Patent granted, date of granting

Effective date: 19980928

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20030331