ATE138690T1 - Verfahren zur enzymatischen herstellung von beta- lactamen - Google Patents

Verfahren zur enzymatischen herstellung von beta- lactamen

Info

Publication number
ATE138690T1
ATE138690T1 AT89201074T AT89201074T ATE138690T1 AT E138690 T1 ATE138690 T1 AT E138690T1 AT 89201074 T AT89201074 T AT 89201074T AT 89201074 T AT89201074 T AT 89201074T AT E138690 T1 ATE138690 T1 AT E138690T1
Authority
AT
Austria
Prior art keywords
beta
lactamen
enzymatic production
enzymatic
aminophenylacetamido
Prior art date
Application number
AT89201074T
Other languages
English (en)
Inventor
Der Laken Cornelis Jacobus Van
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Application granted granted Critical
Publication of ATE138690T1 publication Critical patent/ATE138690T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
AT89201074T 1988-04-26 1989-04-25 Verfahren zur enzymatischen herstellung von beta- lactamen ATE138690T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88200811 1988-04-26

Publications (1)

Publication Number Publication Date
ATE138690T1 true ATE138690T1 (de) 1996-06-15

Family

ID=8199787

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89201074T ATE138690T1 (de) 1988-04-26 1989-04-25 Verfahren zur enzymatischen herstellung von beta- lactamen

Country Status (9)

Country Link
EP (1) EP0339751B1 (de)
JP (1) JP2771244B2 (de)
KR (1) KR890016184A (de)
AT (1) ATE138690T1 (de)
DE (1) DE68926548T2 (de)
DK (1) DK198789A (de)
ES (1) ES2090031T3 (de)
GR (1) GR3020486T3 (de)
PT (1) PT90373B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ381392A3 (en) * 1990-07-04 1993-12-15 Novo Nordisk As Process for preparing beta-lactams
SK63894A3 (en) * 1991-12-19 1995-03-08 Novo Nordisk As Method of preparation of beta-lactam antibiotic
US5753458A (en) * 1994-06-10 1998-05-19 Gist-Brocades B.V. Acylation method for penicillins and cephalosporins
US6048708A (en) * 1994-07-18 2000-04-11 Gist-Brocades B.V. Process for preparation of β-lactams at constantly high concentration of reactants
EP0924180A4 (de) 1996-07-02 2005-04-20 Toray Finechemicals Co Ltd Verfahren zur herstellung von optisch aktiven ketonen
CN1224471A (zh) * 1997-04-22 1999-07-28 吉斯特-布罗卡迪斯有限公司 一种制备β－内酰胺抗生素的方法
WO2012032040A1 (en) 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
CN103635586A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 结晶头孢氧哌唑中间体、其制备方法及其制药用途
PL2723882T3 (pl) 2011-06-23 2020-01-31 Centrient Pharmaceuticals Netherlands B.V. Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5343597B1 (de) * 1970-12-25 1978-11-21
JPS5548797B1 (de) * 1971-04-02 1980-12-08
US3904606A (en) * 1973-01-12 1975-09-09 Upjohn Co Process for preparing optically active 6-(' -amino-acetamido)penicillanic acids and 7-(' -aminoacetamido) cephalosporanic acids
JPS51133488A (en) * 1975-05-14 1976-11-19 Shionogi & Co Ltd Process for producing antibiotics enzymatically
JPS591995Y2 (ja) * 1980-02-21 1984-01-19 日立造船株式会社 微細粒を含有する液体の貯溜槽
JPS63294932A (ja) * 1987-05-27 1988-12-01 Niigata Eng Co Ltd スラリーの貯蔵装置
JPS63294933A (ja) * 1987-05-27 1988-12-01 Niigata Eng Co Ltd スラリ−貯槽

Also Published As

Publication number Publication date
PT90373B (pt) 1994-09-30
JPH01312998A (ja) 1989-12-18
ES2090031T3 (es) 1996-10-16
EP0339751B1 (de) 1996-05-29
GR3020486T3 (en) 1996-10-31
DE68926548T2 (de) 1996-09-26
DE68926548D1 (de) 1996-07-04
KR890016184A (ko) 1989-11-28
JP2771244B2 (ja) 1998-07-02
PT90373A (pt) 1989-11-10
DK198789D0 (da) 1989-04-25
DK198789A (da) 1989-10-27
EP0339751A1 (de) 1989-11-02

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Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee