ATE70064T1 - Verfahren zur herstellung von penemen. - Google Patents
Verfahren zur herstellung von penemen.Info
- Publication number
- ATE70064T1 ATE70064T1 AT87306586T AT87306586T ATE70064T1 AT E70064 T1 ATE70064 T1 AT E70064T1 AT 87306586 T AT87306586 T AT 87306586T AT 87306586 T AT87306586 T AT 87306586T AT E70064 T1 ATE70064 T1 AT E70064T1
- Authority
- AT
- Austria
- Prior art keywords
- penemes
- production
- methods
- dithiabicyclo
- penems
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- JYLUAHUNORBOAL-UHFFFAOYSA-N 8-oxo-4,5-dithia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class OC(=O)C1=CSSC2CC(=O)N12 JYLUAHUNORBOAL-UHFFFAOYSA-N 0.000 abstract 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002961 penems Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Electric Double-Layer Capacitors Or The Like (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Control Of El Displays (AREA)
- Paints Or Removers (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Pens And Brushes (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
- Steroid Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/891,493 US4695626A (en) | 1986-07-29 | 1986-07-29 | 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters |
| EP87306586A EP0255307B1 (de) | 1986-07-29 | 1987-07-24 | Verfahren zur Herstellung von Penemen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE70064T1 true ATE70064T1 (de) | 1991-12-15 |
Family
ID=25398284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87306586T ATE70064T1 (de) | 1986-07-29 | 1987-07-24 | Verfahren zur herstellung von penemen. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4695626A (de) |
| EP (1) | EP0255307B1 (de) |
| JP (1) | JPH0737462B2 (de) |
| KR (1) | KR890004581B1 (de) |
| AT (1) | ATE70064T1 (de) |
| AU (1) | AU583465B2 (de) |
| CA (1) | CA1285275C (de) |
| DE (1) | DE3774954D1 (de) |
| DK (1) | DK170169B1 (de) |
| ES (1) | ES2038665T3 (de) |
| FI (1) | FI87651C (de) |
| GR (1) | GR3003660T3 (de) |
| HU (1) | HU198068B (de) |
| IE (1) | IE60029B1 (de) |
| IL (1) | IL83304A (de) |
| NZ (1) | NZ221201A (de) |
| PT (1) | PT85407B (de) |
| ZA (1) | ZA875541B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77459C (fi) * | 1982-12-08 | 1989-03-10 | Erba Farmitalia | Foerfarande foer framstaellning av (5r)-penemderivat. |
| US4782145A (en) * | 1986-06-02 | 1988-11-01 | Pfizer Inc. | Process for penem derivatives |
| US4751297A (en) * | 1987-03-20 | 1988-06-14 | Pfizer Inc. | Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate |
| US5191077A (en) * | 1987-05-11 | 1993-03-02 | Pfizer Inc. | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids |
| WO1988008845A1 (en) * | 1987-05-11 | 1988-11-17 | Pfizer Inc. | Diastereomeric 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids |
| DE19512050A1 (de) * | 1995-03-31 | 1996-10-02 | Gimmy Lindomare Dr | Vorrichtung zum Sichern von Schrauben vor unbefugtem Zugriff |
| WO2005113592A2 (en) * | 2004-05-19 | 2005-12-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| US7977078B2 (en) | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
| WO2018071358A1 (en) | 2016-10-10 | 2018-04-19 | The Johns Hopkins University | Antibacterial agents against d,d- and l,d-transpeptidases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH541576A (de) * | 1970-11-03 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Herstellung thiaheterocyclischer Verbindungen |
| EP0051813B1 (de) * | 1980-11-06 | 1986-07-30 | Hoechst Uk Limited | 7-Oxo-4-thia-1-aza(3.2.0)heptan- und 7-Oxo-4-thia-1-aza-(3.2.0)hept-2-en-Derivate |
| JPS57176988A (en) * | 1981-04-09 | 1982-10-30 | Sankyo Co Ltd | Penam-3-carboxylic acid derivative and its preparation |
| FI77459C (fi) * | 1982-12-08 | 1989-03-10 | Erba Farmitalia | Foerfarande foer framstaellning av (5r)-penemderivat. |
| GB2131432B (en) * | 1982-12-08 | 1986-10-15 | Erba Farmitalia | Preparation of (5r)-penem derivatives |
| EP0115308A3 (de) * | 1983-01-25 | 1984-10-10 | Merck & Co. Inc. | 2-Ungesättigte Alkylthio-Pen-2-em-3-Carbonsäuren und Verfahren zur Herstellung von substituierten 2-Thioxopenamen und 2-substituierten Thiopenemen |
| DE3464610D1 (de) * | 1983-06-21 | 1987-08-13 | Pfizer | 2-alkylthiopenem derivatives |
| EP0132101A1 (de) * | 1983-07-14 | 1985-01-23 | Pfizer Inc. | 2-Heterocycloalkylthiopenem-Derivate |
-
1986
- 1986-07-29 US US06/891,493 patent/US4695626A/en not_active Expired - Fee Related
-
1987
- 1987-06-16 US US07/062,798 patent/US4782146A/en not_active Expired - Lifetime
- 1987-07-23 IL IL83304A patent/IL83304A/xx not_active IP Right Cessation
- 1987-07-24 ES ES198787306586T patent/ES2038665T3/es not_active Expired - Lifetime
- 1987-07-24 DE DE8787306586T patent/DE3774954D1/de not_active Expired - Fee Related
- 1987-07-24 EP EP87306586A patent/EP0255307B1/de not_active Expired - Lifetime
- 1987-07-24 AT AT87306586T patent/ATE70064T1/de not_active IP Right Cessation
- 1987-07-27 PT PT85407A patent/PT85407B/pt unknown
- 1987-07-27 NZ NZ221201A patent/NZ221201A/xx unknown
- 1987-07-27 CA CA000543040A patent/CA1285275C/en not_active Expired - Fee Related
- 1987-07-28 HU HU873463A patent/HU198068B/hu not_active IP Right Cessation
- 1987-07-28 FI FI873290A patent/FI87651C/fi not_active IP Right Cessation
- 1987-07-28 IE IE204687A patent/IE60029B1/en not_active IP Right Cessation
- 1987-07-28 AU AU76187/87A patent/AU583465B2/en not_active Ceased
- 1987-07-28 ZA ZA875541A patent/ZA875541B/xx unknown
- 1987-07-28 JP JP62186763A patent/JPH0737462B2/ja not_active Expired - Lifetime
- 1987-07-28 KR KR1019870008186A patent/KR890004581B1/ko not_active IP Right Cessation
- 1987-07-28 DK DK392287A patent/DK170169B1/da not_active IP Right Cessation
-
1992
- 1992-01-27 GR GR920400089T patent/GR3003660T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0255307B1 (de) | 1991-12-04 |
| DK170169B1 (da) | 1995-06-06 |
| DE3774954D1 (de) | 1992-01-16 |
| US4782146A (en) | 1988-11-01 |
| FI873290A0 (fi) | 1987-07-28 |
| ZA875541B (en) | 1989-03-29 |
| AU583465B2 (en) | 1989-04-27 |
| JPH0737462B2 (ja) | 1995-04-26 |
| IL83304A0 (en) | 1987-12-31 |
| NZ221201A (en) | 1990-06-26 |
| FI873290A (fi) | 1988-01-30 |
| FI87651B (fi) | 1992-10-30 |
| HUT45067A (en) | 1988-05-30 |
| IL83304A (en) | 1992-06-21 |
| KR890004581B1 (ko) | 1989-11-16 |
| CA1285275C (en) | 1991-06-25 |
| IE60029B1 (en) | 1994-05-18 |
| KR880001668A (ko) | 1988-04-26 |
| PT85407B (pt) | 1990-04-30 |
| AU7618787A (en) | 1988-02-04 |
| US4695626A (en) | 1987-09-22 |
| FI87651C (fi) | 1993-02-10 |
| JPS6341481A (ja) | 1988-02-22 |
| ES2038665T3 (es) | 1993-08-01 |
| DK392287D0 (da) | 1987-07-28 |
| DK392287A (da) | 1988-01-30 |
| HU198068B (en) | 1989-07-28 |
| IE872046L (en) | 1988-01-29 |
| PT85407A (en) | 1987-08-01 |
| GR3003660T3 (de) | 1993-03-16 |
| EP0255307A1 (de) | 1988-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |