DE3774954D1 - Verfahren zur herstellung von penemen. - Google Patents
Verfahren zur herstellung von penemen.Info
- Publication number
- DE3774954D1 DE3774954D1 DE8787306586T DE3774954T DE3774954D1 DE 3774954 D1 DE3774954 D1 DE 3774954D1 DE 8787306586 T DE8787306586 T DE 8787306586T DE 3774954 T DE3774954 T DE 3774954T DE 3774954 D1 DE3774954 D1 DE 3774954D1
- Authority
- DE
- Germany
- Prior art keywords
- penemes
- producing
- dithiabicyclo
- penems
- azetidinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- JYLUAHUNORBOAL-UHFFFAOYSA-N 8-oxo-4,5-dithia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class OC(=O)C1=CSSC2CC(=O)N12 JYLUAHUNORBOAL-UHFFFAOYSA-N 0.000 abstract 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002961 penems Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electric Double-Layer Capacitors Or The Like (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Paints Or Removers (AREA)
- Control Of El Displays (AREA)
- Pens And Brushes (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Steroid Compounds (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/891,493 US4695626A (en) | 1986-07-29 | 1986-07-29 | 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3774954D1 true DE3774954D1 (de) | 1992-01-16 |
Family
ID=25398284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787306586T Expired - Fee Related DE3774954D1 (de) | 1986-07-29 | 1987-07-24 | Verfahren zur herstellung von penemen. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4695626A (de) |
| EP (1) | EP0255307B1 (de) |
| JP (1) | JPH0737462B2 (de) |
| KR (1) | KR890004581B1 (de) |
| AT (1) | ATE70064T1 (de) |
| AU (1) | AU583465B2 (de) |
| CA (1) | CA1285275C (de) |
| DE (1) | DE3774954D1 (de) |
| DK (1) | DK170169B1 (de) |
| ES (1) | ES2038665T3 (de) |
| FI (1) | FI87651C (de) |
| GR (1) | GR3003660T3 (de) |
| HU (1) | HU198068B (de) |
| IE (1) | IE60029B1 (de) |
| IL (1) | IL83304A (de) |
| NZ (1) | NZ221201A (de) |
| PT (1) | PT85407B (de) |
| ZA (1) | ZA875541B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77459C (fi) * | 1982-12-08 | 1989-03-10 | Erba Farmitalia | Foerfarande foer framstaellning av (5r)-penemderivat. |
| US4782145A (en) * | 1986-06-02 | 1988-11-01 | Pfizer Inc. | Process for penem derivatives |
| US4751297A (en) * | 1987-03-20 | 1988-06-14 | Pfizer Inc. | Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate |
| US5191077A (en) * | 1987-05-11 | 1993-03-02 | Pfizer Inc. | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids |
| US5013729A (en) * | 1987-05-11 | 1991-05-07 | Pfizer Inc. | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids |
| DE19512050A1 (de) * | 1995-03-31 | 1996-10-02 | Gimmy Lindomare Dr | Vorrichtung zum Sichern von Schrauben vor unbefugtem Zugriff |
| MXPA06013412A (es) * | 2004-05-19 | 2007-01-23 | Maxygen Inc | Polipeptidos de interferon-alfa y conjugados. |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| WO2018071358A1 (en) * | 2016-10-10 | 2018-04-19 | The Johns Hopkins University | Antibacterial agents against d,d- and l,d-transpeptidases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH541577A (de) * | 1970-11-03 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Herstellung thiaheterocyclischer Verbindungen |
| ATE21105T1 (de) * | 1980-11-06 | 1986-08-15 | Hoechst Uk Ltd | 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate. |
| JPS57176988A (en) * | 1981-04-09 | 1982-10-30 | Sankyo Co Ltd | Penam-3-carboxylic acid derivative and its preparation |
| FI77459C (fi) * | 1982-12-08 | 1989-03-10 | Erba Farmitalia | Foerfarande foer framstaellning av (5r)-penemderivat. |
| GB2131432B (en) * | 1982-12-08 | 1986-10-15 | Erba Farmitalia | Preparation of (5r)-penem derivatives |
| EP0115308A3 (de) * | 1983-01-25 | 1984-10-10 | Merck & Co. Inc. | 2-Ungesättigte Alkylthio-Pen-2-em-3-Carbonsäuren und Verfahren zur Herstellung von substituierten 2-Thioxopenamen und 2-substituierten Thiopenemen |
| EP0130025B1 (de) * | 1983-06-21 | 1987-07-08 | Pfizer Inc. | 2-Alkylthiopenem-Derivate |
| EP0132101A1 (de) * | 1983-07-14 | 1985-01-23 | Pfizer Inc. | 2-Heterocycloalkylthiopenem-Derivate |
-
1986
- 1986-07-29 US US06/891,493 patent/US4695626A/en not_active Expired - Fee Related
-
1987
- 1987-06-16 US US07/062,798 patent/US4782146A/en not_active Expired - Lifetime
- 1987-07-23 IL IL83304A patent/IL83304A/xx not_active IP Right Cessation
- 1987-07-24 EP EP87306586A patent/EP0255307B1/de not_active Expired - Lifetime
- 1987-07-24 AT AT87306586T patent/ATE70064T1/de not_active IP Right Cessation
- 1987-07-24 DE DE8787306586T patent/DE3774954D1/de not_active Expired - Fee Related
- 1987-07-24 ES ES198787306586T patent/ES2038665T3/es not_active Expired - Lifetime
- 1987-07-27 CA CA000543040A patent/CA1285275C/en not_active Expired - Fee Related
- 1987-07-27 PT PT85407A patent/PT85407B/pt unknown
- 1987-07-27 NZ NZ221201A patent/NZ221201A/xx unknown
- 1987-07-28 ZA ZA875541A patent/ZA875541B/xx unknown
- 1987-07-28 AU AU76187/87A patent/AU583465B2/en not_active Ceased
- 1987-07-28 JP JP62186763A patent/JPH0737462B2/ja not_active Expired - Lifetime
- 1987-07-28 FI FI873290A patent/FI87651C/fi not_active IP Right Cessation
- 1987-07-28 KR KR1019870008186A patent/KR890004581B1/ko not_active IP Right Cessation
- 1987-07-28 IE IE204687A patent/IE60029B1/en not_active IP Right Cessation
- 1987-07-28 DK DK392287A patent/DK170169B1/da not_active IP Right Cessation
- 1987-07-28 HU HU873463A patent/HU198068B/hu not_active IP Right Cessation
-
1992
- 1992-01-27 GR GR920400089T patent/GR3003660T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE60029B1 (en) | 1994-05-18 |
| KR880001668A (ko) | 1988-04-26 |
| FI873290A0 (fi) | 1987-07-28 |
| ZA875541B (en) | 1989-03-29 |
| GR3003660T3 (de) | 1993-03-16 |
| DK170169B1 (da) | 1995-06-06 |
| AU7618787A (en) | 1988-02-04 |
| PT85407A (en) | 1987-08-01 |
| JPH0737462B2 (ja) | 1995-04-26 |
| US4695626A (en) | 1987-09-22 |
| PT85407B (pt) | 1990-04-30 |
| IE872046L (en) | 1988-01-29 |
| AU583465B2 (en) | 1989-04-27 |
| HUT45067A (en) | 1988-05-30 |
| IL83304A (en) | 1992-06-21 |
| FI87651C (fi) | 1993-02-10 |
| KR890004581B1 (ko) | 1989-11-16 |
| ATE70064T1 (de) | 1991-12-15 |
| FI87651B (fi) | 1992-10-30 |
| FI873290A (fi) | 1988-01-30 |
| JPS6341481A (ja) | 1988-02-22 |
| EP0255307A1 (de) | 1988-02-03 |
| HU198068B (en) | 1989-07-28 |
| IL83304A0 (en) | 1987-12-31 |
| CA1285275C (en) | 1991-06-25 |
| EP0255307B1 (de) | 1991-12-04 |
| DK392287D0 (da) | 1987-07-28 |
| US4782146A (en) | 1988-11-01 |
| DK392287A (da) | 1988-01-30 |
| NZ221201A (en) | 1990-06-26 |
| ES2038665T3 (es) | 1993-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |