ES2038665T3 - Procedimiento de sintesis de penems. - Google Patents

Procedimiento de sintesis de penems.

Info

Publication number
ES2038665T3
ES2038665T3 ES198787306586T ES87306586T ES2038665T3 ES 2038665 T3 ES2038665 T3 ES 2038665T3 ES 198787306586 T ES198787306586 T ES 198787306586T ES 87306586 T ES87306586 T ES 87306586T ES 2038665 T3 ES2038665 T3 ES 2038665T3
Authority
ES
Spain
Prior art keywords
penems
synthesis procedure
synthesis
procedure
ditiabiciclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787306586T
Other languages
English (en)
Inventor
Catherine Elizabeth Brighty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Application granted granted Critical
Publication of ES2038665T3 publication Critical patent/ES2038665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pens And Brushes (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Paints Or Removers (AREA)
  • Control Of El Displays (AREA)

Abstract

UN PROCEDIMIENTO PARA LA SINTESIS DE PENEMS A PARTIR DE ACETIDINONAS POR MEDIO DE ESTERES 2-CARBOXILICOS DE 1-AZA-4,5-DITIABICICLO[4.2.0]OCT-2-EN-8-ONA.
ES198787306586T 1986-07-29 1987-07-24 Procedimiento de sintesis de penems. Expired - Lifetime ES2038665T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/891,493 US4695626A (en) 1986-07-29 1986-07-29 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters

Publications (1)

Publication Number Publication Date
ES2038665T3 true ES2038665T3 (es) 1993-08-01

Family

ID=25398284

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787306586T Expired - Lifetime ES2038665T3 (es) 1986-07-29 1987-07-24 Procedimiento de sintesis de penems.

Country Status (18)

Country Link
US (2) US4695626A (es)
EP (1) EP0255307B1 (es)
JP (1) JPH0737462B2 (es)
KR (1) KR890004581B1 (es)
AT (1) ATE70064T1 (es)
AU (1) AU583465B2 (es)
CA (1) CA1285275C (es)
DE (1) DE3774954D1 (es)
DK (1) DK170169B1 (es)
ES (1) ES2038665T3 (es)
FI (1) FI87651C (es)
GR (1) GR3003660T3 (es)
HU (1) HU198068B (es)
IE (1) IE60029B1 (es)
IL (1) IL83304A (es)
NZ (1) NZ221201A (es)
PT (1) PT85407B (es)
ZA (1) ZA875541B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1221358A (en) * 1982-12-08 1987-05-05 Erba Farmitalia 2-thiacephems and (5r) penems derivatives
US4782145A (en) * 1986-06-02 1988-11-01 Pfizer Inc. Process for penem derivatives
US4751297A (en) * 1987-03-20 1988-06-14 Pfizer Inc. Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate
US5013729A (en) * 1987-05-11 1991-05-07 Pfizer Inc. Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
US5191077A (en) * 1987-05-11 1993-03-02 Pfizer Inc. Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
DE19512050A1 (de) * 1995-03-31 1996-10-02 Gimmy Lindomare Dr Vorrichtung zum Sichern von Schrauben vor unbefugtem Zugriff
JP2008507298A (ja) * 2004-05-19 2008-03-13 マキシジェン， インコーポレイテッド インターフェロンαポリペプチドおよび結合体
WO2009029554A2 (en) * 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
CN110062760A (zh) * 2016-10-10 2019-07-26 约翰霍普金斯大学 抗d,d-转肽酶和l,d-转肽酶的抗细菌剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH541576A (de) * 1970-11-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung thiaheterocyclischer Verbindungen
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
JPS57176988A (en) * 1981-04-09 1982-10-30 Sankyo Co Ltd Penam-3-carboxylic acid derivative and its preparation
GB2131432B (en) * 1982-12-08 1986-10-15 Erba Farmitalia Preparation of (5r)-penem derivatives
CA1221358A (en) * 1982-12-08 1987-05-05 Erba Farmitalia 2-thiacephems and (5r) penems derivatives
EP0115308A3 (en) * 1983-01-25 1984-10-10 Merck & Co. Inc. 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids and process for preparing substituted 2-thioxopenams and 2-substituted thiopenems
DE3464610D1 (de) * 1983-06-21 1987-08-13 Pfizer 2-alkylthiopenem derivatives
EP0132101A1 (en) * 1983-07-14 1985-01-23 Pfizer Inc. 2-Heterocycloalkylthiopenem derivatives

Also Published As

Publication number Publication date
GR3003660T3 (es) 1993-03-16
KR890004581B1 (ko) 1989-11-16
EP0255307A1 (en) 1988-02-03
FI87651C (fi) 1993-02-10
DK392287A (da) 1988-01-30
FI873290A0 (fi) 1987-07-28
ZA875541B (en) 1989-03-29
DK392287D0 (da) 1987-07-28
DK170169B1 (da) 1995-06-06
NZ221201A (en) 1990-06-26
JPS6341481A (ja) 1988-02-22
ATE70064T1 (de) 1991-12-15
CA1285275C (en) 1991-06-25
DE3774954D1 (de) 1992-01-16
PT85407A (en) 1987-08-01
US4695626A (en) 1987-09-22
AU583465B2 (en) 1989-04-27
HU198068B (en) 1989-07-28
FI873290A7 (fi) 1988-01-30
IL83304A0 (en) 1987-12-31
IE872046L (en) 1988-01-29
FI87651B (fi) 1992-10-30
PT85407B (pt) 1990-04-30
HUT45067A (en) 1988-05-30
IL83304A (en) 1992-06-21
EP0255307B1 (en) 1991-12-04
US4782146A (en) 1988-11-01
IE60029B1 (en) 1994-05-18
AU7618787A (en) 1988-02-04
JPH0737462B2 (ja) 1995-04-26
KR880001668A (ko) 1988-04-26

Similar Documents

Publication Publication Date Title
MY105224A (en) Catalysts for the polymerization of olefins.
ZA941968B (en) Process for the purification of taxoids
AU6751887A (en) 4,5,6-substituted-2-pyrimidinamines
IL115790A0 (en) Pharmaceutical compositions containing boronic ester and acid compounds and methods for the preparation thereof
GR3006319T3 (es)
IT8719189A0 (it) Procedimento per gasificare fanghi di chiarificazione.
UA5972A1 (uk) Спосіб отримання заміщених 2-меркапто-імідазолів
MX17846A (es) Proceso para la preparacion de nuevos derivados de 9h purina.
DK314487A (da) Benzoxepinderivat
ES2038665T3 (es) Procedimiento de sintesis de penems.
ES2060862T3 (es) Procedimiento para la preparacion de d,l-lactida.
DZ1569A1 (fr) Procédé de préparation de ginkgolide b a partir deginkgolide c.
BG101794A (en) Method for the preparation of trihydrate of (2r, 3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate of 4, 10-diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1,7 beta -dihydroxy-9-oco-tax-11-en-13 alpha-yl
FR2659665B1 (fr) Procede d'affinage, notamment de decuivrage, du plomb.
GR1001203B (el) Μεθοδος παρασκευης της ενωσεως 24r-σκυμνολη.
IT8820391A0 (it) Macchina per rincalzare il binario.
IT1240497B (it) Cantra per orditoi.
FI885631A0 (fi) Bilddisplayanordning som omfattar generator foer alstrande av trappstegsvaog.
IT1230866B (it) Procedimento per la produzione di coke.
FR2700538B1 (fr) Procédé de préparation de 2-méthyl-3-aminobenzotrifluorure.
GR1001309B (el) Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
ES2129573T3 (es) Procedimiento para la preparacion de articulos de poliuretano a partir de composiciones basadas en uretonimina.
IT8719775A0 (it) Procedimento per la produzione di un filato di poliammide-6.
EP0305667A3 (en) Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid
ES2021616B3 (es) Procedimiento para la obtencion de polimerizados a partir de sus dispersiones.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 255307

Country of ref document: ES