JP2010509284A5 - - Google Patents

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JP2010509284A5
JP2010509284A5 JP2009535728A JP2009535728A JP2010509284A5 JP 2010509284 A5 JP2010509284 A5 JP 2010509284A5 JP 2009535728 A JP2009535728 A JP 2009535728A JP 2009535728 A JP2009535728 A JP 2009535728A JP 2010509284 A5 JP2010509284 A5 JP 2010509284A5
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compound
heteroaryl
aryl
compound according
alkyl
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JP2009535728A
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JP2010509284A (ja
JP5379692B2 (ja
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Priority claimed from PCT/EP2007/062030 external-priority patent/WO2008055945A1/en
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JP2009535728A 2006-11-09 2007-11-08 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 Active JP5379692B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86498606P 2006-11-09 2006-11-09
US60/864,986 2006-11-09
PCT/EP2007/062030 WO2008055945A1 (en) 2006-11-09 2007-11-08 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013154932A Division JP5798157B2 (ja) 2006-11-09 2013-07-25 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体

Publications (3)

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JP2010509284A JP2010509284A (ja) 2010-03-25
JP2010509284A5 true JP2010509284A5 (US20040106767A1-20040603-C00005.png) 2011-02-17
JP5379692B2 JP5379692B2 (ja) 2013-12-25

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JP2009535728A Active JP5379692B2 (ja) 2006-11-09 2007-11-08 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
JP2013154932A Active JP5798157B2 (ja) 2006-11-09 2013-07-25 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体

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JP2013154932A Active JP5798157B2 (ja) 2006-11-09 2013-07-25 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体

Country Status (4)

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US (1) US8278345B2 (US20040106767A1-20040603-C00005.png)
EP (1) EP2089383B1 (US20040106767A1-20040603-C00005.png)
JP (2) JP5379692B2 (US20040106767A1-20040603-C00005.png)
WO (1) WO2008055945A1 (US20040106767A1-20040603-C00005.png)

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EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
JP5952816B2 (ja) 2010-08-19 2016-07-13 プロビオドルグ エージー グルタミニルシクラーゼの結晶構造
JP6050264B2 (ja) * 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
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WO2015004610A1 (en) 2013-07-11 2015-01-15 Adamed Sp. Z O.O. 1,5-dihydropyrrol-2-one derivatives as inhibitors of p53-mdm2/mdm4 protein-protein interaction
US20170363645A1 (en) 2014-12-19 2017-12-21 Probiodrug Ag Novel Method for the Detection of pGlu-Abeta Peptides
US20180104220A1 (en) * 2015-04-24 2018-04-19 Medshine Discovery Inc. Imidazole compound
WO2018072702A1 (zh) * 2016-10-20 2018-04-26 南京明德新药研发股份有限公司 一种咪唑类化合物的晶型、盐型及其制备方法
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
EP3543231A1 (en) * 2018-03-19 2019-09-25 ETH Zurich Compounds for treating cns- and neurodegenerative diseases
CN109535140A (zh) * 2018-12-29 2019-03-29 常州大学 一种基于肟酯与吲哚构建双吲哚取代二氢吡咯酮类衍生物的方法

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