MX2009003090A - Genes novedosos relacionados con ciclasa de glutaminilo. - Google Patents

Genes novedosos relacionados con ciclasa de glutaminilo.

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Publication number
MX2009003090A
MX2009003090A MX2009003090A MX2009003090A MX2009003090A MX 2009003090 A MX2009003090 A MX 2009003090A MX 2009003090 A MX2009003090 A MX 2009003090A MX 2009003090 A MX2009003090 A MX 2009003090A MX 2009003090 A MX2009003090 A MX 2009003090A
Authority
MX
Mexico
Prior art keywords
glutaminyl cyclase
isoenzymes
glutaminyl
cyclase
genes related
Prior art date
Application number
MX2009003090A
Other languages
English (en)
Inventor
Hans-Ulrich Demuth
Stephen Schilling
Holger Cynis
Jens-Ulrich Rahfeld
Original Assignee
Probiodrug Ag
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Publication date
Application filed by Probiodrug Ag filed Critical Probiodrug Ag
Publication of MX2009003090A publication Critical patent/MX2009003090A/es

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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
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Abstract

La presente invención se refiere a una proteína tipo ciclotransferasa de péptido-glutaminilo novedosas QPCTLs, que son isoenzimas de ciclasa de glutaminilo (QC, EC 2.3.3.5), y a ácidos nucleicos aislados que codifican estas isoenzimas, las cuales todas son útiles para el descubrimiento de nuevos agentes terapéuticos, para medir la actividad de ciclasa, y para determinar la actividad inhibidora de los compuestos contra estas isoenzimas de ciclasa de glutaminilo.
MX2009003090A 2006-09-21 2007-09-21 Genes novedosos relacionados con ciclasa de glutaminilo. MX2009003090A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (1)

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MX2009003090A true MX2009003090A (es) 2009-04-02

Family

ID=38779576

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Application Number Title Priority Date Filing Date
MX2009003090A MX2009003090A (es) 2006-09-21 2007-09-21 Genes novedosos relacionados con ciclasa de glutaminilo.

Country Status (13)

Country Link
US (3) US20080249083A1 (es)
EP (2) EP2082041B1 (es)
JP (1) JP2010504088A (es)
KR (1) KR101432848B1 (es)
AU (1) AU2007298929B2 (es)
BR (1) BRPI0718507A2 (es)
CA (1) CA2663635A1 (es)
EA (1) EA016584B1 (es)
HK (1) HK1136603A1 (es)
IL (2) IL197090A (es)
MX (1) MX2009003090A (es)
NZ (2) NZ575727A (es)
WO (1) WO2008034891A2 (es)

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US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
EA016584B1 (ru) 2006-09-21 2012-06-29 Пробиодруг Аг Новые гены, родственные гену глутаминилциклазы
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008055945A1 (en) * 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
JP5599614B2 (ja) * 2006-11-09 2014-10-01 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
US9126987B2 (en) * 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
DK2121944T3 (da) * 2007-01-19 2011-10-31 Probiodrug Ag In vivo screeningsmodeller til behandling af Alzheimers sygdom og andre QPCT-relaterede lidelser
EP2118101B1 (en) * 2007-03-09 2012-09-26 Probiodrug AG Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase
EP2146968B1 (en) * 2007-04-18 2015-09-23 Probiodrug AG Urea derivatives as glutaminyl cyclase inhibitors
WO2008128981A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
EP2160380B1 (en) * 2007-04-18 2014-04-02 Probiodrug AG Cyano-guanidine derivatives as glutaminyl cyclase inhibitors
US8202897B2 (en) * 2007-04-18 2012-06-19 Probiodrug Ag Inhibitors of glutaminyl cyclases
DK2160389T3 (da) * 2007-04-18 2014-06-23 Probiodrug Ag Thioxoquinazolinonderivater som glutaminylcyclaseinhibitorer
EP2865670B1 (en) * 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
WO2009034158A2 (en) * 2007-09-12 2009-03-19 Probiodrug Ag Transgenic mice
WO2009090190A1 (en) * 2008-01-14 2009-07-23 Probiodrug Ag Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
US20100028918A1 (en) * 2008-07-31 2010-02-04 Probiodrug Ag Glutaminyl cyclase as a diagnostic/prognostic indicator for neurodegenerative diseases
EA021150B1 (ru) 2008-09-04 2015-04-30 Пробиодруг Аг Производные имидазолидина в качестве ингибиторов глутаминилциклазы
WO2010026209A1 (en) * 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors
AU2010251176A1 (en) * 2009-05-19 2011-12-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
US20110212853A1 (en) * 2010-02-18 2011-09-01 Probiodrug Ag Novel diagnostic method
US8409837B2 (en) 2010-08-19 2013-04-02 Probiodrug Ag Crystal structure of glutaminyl cyclase
JP2013541938A (ja) 2010-09-02 2013-11-21 プロビオドルグ エージー アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル
JP6026425B2 (ja) 2010-11-02 2016-11-16 プロビオドルグ エージー イソグルタミニルシクラーゼの結晶構造
JP6397407B2 (ja) 2012-07-19 2018-09-26 ドレクセル ユニバーシティ 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド
US20180318260A1 (en) * 2015-11-04 2018-11-08 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
EP3658141B1 (en) * 2017-07-24 2022-11-16 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Treating pathological conditions by direct and indirect targeting of sirpalpha - cd47 interaction
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases
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JP2010504088A (ja) 2010-02-12
US20080249083A1 (en) 2008-10-09
CA2663635A1 (en) 2008-03-27
WO2008034891A3 (en) 2008-05-08
IL197090A0 (en) 2011-08-01
KR20090059163A (ko) 2009-06-10
AU2007298929B2 (en) 2012-09-27
EP2581449B1 (en) 2016-09-14
IL197090A (en) 2016-03-31
EP2082041A2 (en) 2009-07-29
EA200900404A1 (ru) 2009-10-30
AU2007298929A1 (en) 2008-03-27
US8647834B2 (en) 2014-02-11
US8129160B2 (en) 2012-03-06
US20100009337A1 (en) 2010-01-14
NZ590631A (en) 2011-12-22
US20120183974A1 (en) 2012-07-19
EP2581449A3 (en) 2013-07-31
WO2008034891A2 (en) 2008-03-27
KR101432848B1 (ko) 2014-08-27
EA016584B1 (ru) 2012-06-29
EP2581449A2 (en) 2013-04-17
BRPI0718507A2 (pt) 2013-11-12
HK1136603A1 (zh) 2010-07-02
NZ575727A (en) 2011-12-22

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