HK1136603A1 - 與谷氨酰環化酶相關的新基因 - Google Patents

與谷氨酰環化酶相關的新基因

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Publication number
HK1136603A1
HK1136603A1 HK10104168.6A HK10104168A HK1136603A1 HK 1136603 A1 HK1136603 A1 HK 1136603A1 HK 10104168 A HK10104168 A HK 10104168A HK 1136603 A1 HK1136603 A1 HK 1136603A1
Authority
HK
Hong Kong
Prior art keywords
genes related
novel genes
glutaminyl cyclase
glutaminyl
cyclase
Prior art date
Application number
HK10104168.6A
Other languages
English (en)
Inventor
‧席林
‧欽尼斯
‧拉赫菲爾德
‧德穆特
Original Assignee
前體生物藥物股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 前體生物藥物股份公司 filed Critical 前體生物藥物股份公司
Publication of HK1136603A1 publication Critical patent/HK1136603A1/zh

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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
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  • Pharmacology & Pharmacy (AREA)
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  • Biotechnology (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Dermatology (AREA)
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HK10104168.6A 2006-09-21 2010-04-28 與谷氨酰環化酶相關的新基因 HK1136603A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (1)

Publication Number Publication Date
HK1136603A1 true HK1136603A1 (zh) 2010-07-02

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HK10104168.6A HK1136603A1 (zh) 2006-09-21 2010-04-28 與谷氨酰環化酶相關的新基因

Country Status (13)

Country Link
US (3) US20080249083A1 (zh)
EP (2) EP2581449B1 (zh)
JP (1) JP2010504088A (zh)
KR (1) KR101432848B1 (zh)
AU (1) AU2007298929B2 (zh)
BR (1) BRPI0718507A2 (zh)
CA (1) CA2663635A1 (zh)
EA (1) EA016584B1 (zh)
HK (1) HK1136603A1 (zh)
IL (2) IL197090A (zh)
MX (1) MX2009003090A (zh)
NZ (2) NZ590631A (zh)
WO (1) WO2008034891A2 (zh)

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CN101837127A (zh) * 2003-05-05 2010-09-22 前体生物药物股份公司 谷氨酰胺酰基和谷氨酸环化酶效应物的应用
EA016584B1 (ru) * 2006-09-21 2012-06-29 Пробиодруг Аг Новые гены, родственные гену глутаминилциклазы
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008055945A1 (en) * 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2086960B1 (en) * 2006-11-09 2014-03-05 Probiodrug AG Novel inhibitors of glutaminyl cyclase
WO2008065141A1 (en) * 2006-11-30 2008-06-05 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
ES2372229T3 (es) * 2007-01-19 2012-01-17 Probiodrug Ag Modelos de selección in vivo para el tratamiento de la enfermedad de alzheimer y otros trastornos relacionados con qpct.
US20120070444A1 (en) 2007-01-19 2012-03-22 Probiodrug Ag IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS
JP5612860B2 (ja) * 2007-03-09 2014-10-22 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体
JP5667440B2 (ja) * 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
ES2474693T3 (es) * 2007-04-18 2014-07-09 Probiodrug Ag Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa
WO2008128986A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Urea derivatives as glutaminyl cyclase inhibitors
JP5675344B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのニトロビニルジアミン誘導体
JP5675340B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー 新規阻害剤
EP2160389B1 (en) * 2007-04-18 2014-03-12 Probiodrug AG Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors
WO2008128984A1 (en) * 2007-04-20 2008-10-30 Probiodrug Ag Aminopyrimidine derivatives as glutaminyl cyclase inhibitors
CA2696934A1 (en) * 2007-09-12 2010-02-16 Probiodrug Ag Transgenic mice
JP2011511622A (ja) * 2008-01-14 2011-04-14 プロビオドルグ エージー グルタミニルシクラーゼ遺伝子のノックアウト変異を有するマウスモデル
US20100028918A1 (en) * 2008-07-31 2010-02-04 Probiodrug Ag Glutaminyl cyclase as a diagnostic/prognostic indicator for neurodegenerative diseases
WO2010026209A1 (en) * 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors
US8962860B2 (en) * 2008-09-04 2015-02-24 Probiodrug Ag Inhibitors of glutaminyl cyclase
SG176164A1 (en) * 2009-05-19 2011-12-29 Probiodrug Ag Mouse models carrying a knock-out mutation of the qpctl-gene
WO2011101433A1 (en) * 2010-02-18 2011-08-25 Probiodrug Ag Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
EP2606129B1 (en) 2010-08-19 2015-03-25 Probiodrug AG Crystal structure of glutaminyl cyclase
US8741614B2 (en) 2010-11-02 2014-06-03 Probiodrug Ag Crystal structure of isoglutaminyl cyclase
JP6397407B2 (ja) 2012-07-19 2018-09-26 ドレクセル ユニバーシティ 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド
US20180318260A1 (en) * 2015-11-04 2018-11-08 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
AU2018308191B2 (en) * 2017-07-24 2023-12-21 Scenic Immunology B.V. Treating pathological conditions by direct and indirect targeting of SIRPa - CD47 interaction
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases
GB201918108D0 (en) * 2019-12-10 2020-01-22 Vib Vzw Improved aminopeptiadases for single molecule peptide sequencing

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IL214820A (en) 2016-06-30
BRPI0718507A2 (pt) 2013-11-12
NZ590631A (en) 2011-12-22
EP2082041A2 (en) 2009-07-29
JP2010504088A (ja) 2010-02-12
CA2663635A1 (en) 2008-03-27
EP2082041B1 (en) 2018-03-14
AU2007298929B2 (en) 2012-09-27
EA016584B1 (ru) 2012-06-29
IL197090A0 (en) 2011-08-01
WO2008034891A3 (en) 2008-05-08
US8647834B2 (en) 2014-02-11
KR101432848B1 (ko) 2014-08-27
EA200900404A1 (ru) 2009-10-30
EP2581449B1 (en) 2016-09-14
US20120183974A1 (en) 2012-07-19
NZ575727A (en) 2011-12-22
WO2008034891A2 (en) 2008-03-27
US20080249083A1 (en) 2008-10-09
AU2007298929A1 (en) 2008-03-27
US20100009337A1 (en) 2010-01-14
MX2009003090A (es) 2009-04-02
IL214820A0 (en) 2011-09-27
EP2581449A3 (en) 2013-07-31
IL197090A (en) 2016-03-31
KR20090059163A (ko) 2009-06-10
EP2581449A2 (en) 2013-04-17
US8129160B2 (en) 2012-03-06

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