EA201001014A1 - Фармацевтически приемлемые соли метил (3-{[[3-(6-амино-2-бутокси-8-оксо-7,8-дигидро-9h-пурин-9-ил)пропил](3-морфолин-4-илпропил)амино]метил}фенил)ацетата и их применение в терапии - Google Patents

Фармацевтически приемлемые соли метил (3-{[[3-(6-амино-2-бутокси-8-оксо-7,8-дигидро-9h-пурин-9-ил)пропил](3-морфолин-4-илпропил)амино]метил}фенил)ацетата и их применение в терапии

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Publication number
EA201001014A1
EA201001014A1 EA201001014A EA201001014A EA201001014A1 EA 201001014 A1 EA201001014 A1 EA 201001014A1 EA 201001014 A EA201001014 A EA 201001014A EA 201001014 A EA201001014 A EA 201001014A EA 201001014 A1 EA201001014 A1 EA 201001014A1
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EA
Eurasian Patent Office
Prior art keywords
amino
methyl
purin
dihydro
oxo
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EA201001014A
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English (en)
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EA017532B1 (ru
Inventor
Томас МакИналли
Хокан Шульц
Original Assignee
Астразенека Аб
ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД.
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Application filed by Астразенека Аб, ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. filed Critical Астразенека Аб
Publication of EA201001014A1 publication Critical patent/EA201001014A1/ru
Publication of EA017532B1 publication Critical patent/EA017532B1/ru

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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/52—Purines, e.g. adenine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Настоящее изобретение относится к солям метил-(3-{[[3-(6-амино-2-бутокси-8-оксо-7,8-дигидро-9Н-пурин-9-ил)пропил](3-морфолин-4-илпропил)амино]метил}фенил)ацетата с соляной кислотой, бромисто-водородной кислотой и малеиновой кислотой, содержащим их композициям и их применению в терапии.
EA201001014A 2007-12-17 2008-12-16 Фармацевтически приемлемые соли метил-(3-{[[3-(6-амино-2-бутокси-8-оксо-7,8-дигидро-9н-пурин-9-ил)пропил](3-морфолин-4-илпропил)амино]метил}фенил)ацетата и их применение в терапии EA017532B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1416407P 2007-12-17 2007-12-17
PCT/SE2008/051465 WO2009078798A1 (en) 2007-12-17 2008-12-16 Pharmaceutically acceptable salts of methyl (3-{ [[3-(6- amino- 2-butoxy-8-oxo-7, 8-dihydro-9h-purin-9-yl) propyl] (3- morpholin-4-ylpropyl) amino] methyl }phenyl) acetate and their use in therapy

Publications (2)

Publication Number Publication Date
EA201001014A1 true EA201001014A1 (ru) 2011-02-28
EA017532B1 EA017532B1 (ru) 2013-01-30

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EA201001014A EA017532B1 (ru) 2007-12-17 2008-12-16 Фармацевтически приемлемые соли метил-(3-{[[3-(6-амино-2-бутокси-8-оксо-7,8-дигидро-9н-пурин-9-ил)пропил](3-морфолин-4-илпропил)амино]метил}фенил)ацетата и их применение в терапии

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KR (2) KR20100093566A (ru)
CN (1) CN101903389B (ru)
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AU (1) AU2008339095B2 (ru)
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TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
ES2457316T3 (es) 2007-03-19 2014-04-25 Astrazeneca Ab Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7)
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JPWO2008114819A1 (ja) 2007-03-20 2010-07-08 大日本住友製薬株式会社 新規アデニン化合物
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
US20110054168A1 (en) * 2008-01-17 2011-03-03 Ayumu Kurimoto Method for preparing adenine compound
US8865896B2 (en) * 2008-01-17 2014-10-21 Astrazeneca Aktiebolag Method for preparing adenine compound
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