DK3070090T3 - Anvendelse af salte af janus-kinase-inhibitoren (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropannitril - Google Patents
Anvendelse af salte af janus-kinase-inhibitoren (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropannitril Download PDFInfo
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- DK3070090T3 DK3070090T3 DK16152794.0T DK16152794T DK3070090T3 DK 3070090 T3 DK3070090 T3 DK 3070090T3 DK 16152794 T DK16152794 T DK 16152794T DK 3070090 T3 DK3070090 T3 DK 3070090T3
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- jak
- salt
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- pyrrolo
- pyrazol
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Claims (4)
1. Anvendelse af et salt valgt fra gruppen bestående af: (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-lH-pyrazol-l-yl)-3-cyclopentylpropannitril fosforsyresalt; (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-lH-pyrazol-l-yl)-3-cyclopentylpropannitril svovlsyresalt; og (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-lH-pyrazol-l-yl)-3-cyclopentylpropannitril maleinsyresalt, til fremstilling af et medikament til behandlingen af polycytæmia vera.
2. Anvendelse ifølge krav 1, hvor saltet er (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-lH-pyrazol-l-yl)-3-cyclopentylpropannitril fosforsyresalt.
3. Anvendelse ifølge krav 1 eller krav 2, hvor saltet er krystallinsk.
4. Anvendelse ifølge krav 3, hvor det krystallinske salt er 1:1 (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-lH-pyrazol-l-yl)-3-cyclopentylpropannitril: fosforsyresalt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94370507P | 2007-06-13 | 2007-06-13 | |
EP13198120.1A EP2740731B1 (en) | 2007-06-13 | 2008-06-12 | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
Publications (1)
Publication Number | Publication Date |
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DK3070090T3 true DK3070090T3 (da) | 2019-03-18 |
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ID=40029273
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16152794.0T DK3070090T3 (da) | 2007-06-13 | 2008-06-12 | Anvendelse af salte af janus-kinase-inhibitoren (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropannitril |
DK13198120.1T DK2740731T3 (da) | 2007-06-13 | 2008-06-12 | Krystallinske salte af januskinaseinhibitoren (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril |
DK08770794.9T DK2173752T4 (en) | 2007-06-13 | 2008-06-12 | Salte af janus-kinase-inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13198120.1T DK2740731T3 (da) | 2007-06-13 | 2008-06-12 | Krystallinske salte af januskinaseinhibitoren (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril |
DK08770794.9T DK2173752T4 (en) | 2007-06-13 | 2008-06-12 | Salte af janus-kinase-inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril |
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Families Citing this family (115)
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