DK2361932T3 - Kimære immunoglobulinmonomer-dimerhybrider - Google Patents

Kimære immunoglobulinmonomer-dimerhybrider Download PDF

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Publication number
DK2361932T3
DK2361932T3 DK10182890.3T DK10182890T DK2361932T3 DK 2361932 T3 DK2361932 T3 DK 2361932T3 DK 10182890 T DK10182890 T DK 10182890T DK 2361932 T3 DK2361932 T3 DK 2361932T3
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Prior art keywords
chimeric protein
factor
biologically active
protein
active molecule
Prior art date
Application number
DK10182890.3T
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English (en)
Inventor
Adam R Mezo
Daniel S Rivera
Alan J Bitonti
James M Stattel
Susan C Low
Robert T Peters
Original Assignee
Biogen Hemophilia Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33458764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2361932(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Hemophilia Inc filed Critical Biogen Hemophilia Inc
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Publication of DK2361932T3 publication Critical patent/DK2361932T3/da

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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Claims (19)

1. Kimærisk protein, til anvendelse i en fremgangsmåde til behandling, med et biologisk aktivt molekyle og to konstante immunoglobulinregioner eller dele deraf, hvor det kimæriske protein omfatter en første polypeptidkæde og en anden polypeptidkæde, hvor den første polypeptidkæde omfatter det biologisk aktive molekyle og en konstant immunoglobulinregion, eller en del deraf, der er en Fc-neonatal-receptor-(FcRn) bindingspartner, og hvor det biologisk aktive molekyle er et protein udvalgt fra gruppen bestående af et cytokin, et hormon og en koagulationsfaktor; og hvor den anden polypeptidkæde består af en konstant immunoglobulinregion, eller en del deraf, der er en FcRn-bindingspartner og eventuelt et molekyle med en molekylvægt på ikke større end 2 kD.
2. Kimærisk protein til anvendelse ifølge krav 1, hvor den første polypeptidkæde endvidere omfatter en linker mellem proteinet og den konstante immunoglobulinregion eller delen deraf.
3. Kimærisk protein til anvendelse ifølge krav 1 eller krav 2, hvor delen af den konstante immunoglobulinregion af den første polypeptidkæde er et Fc-fragment og delen af den konstante immunoglobulinregion af den anden polypeptidkæde er et Fc-fragment.
4. Kimærisk protein til anvendelse ifølge et hvilket som helst af kravene 1 til 3, hvor den konstante immunoglobulinregion er en konstant IgGl- eller lgG2-region.
5. Kimærisk protein til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor proteinet i den første polypeptidkæde er en koagulationsfaktor.
6. Kimærisk protein til anvendelse ifølge krav 5, hvor koagulationsfaktoren er udvalgt fra gruppen bestående af Faktor VII, Faktor Vila, Faktor VIII, Faktor V, Faktor IX, Faktor X, Faktor XI, Faktor XII, Faktor XIII, fibrinogen, prothrombin og von Willebrand Faktor.
7. Kimærisk protein til anvendelse ifølge krav 6, hvor koagulationsfaktoren er Faktor IX.
8. Kimærisk protein til anvendelse ifølge krav 6, hvor koagulationsfaktoren er Faktor VIII.
9. Kimærisk protein til anvendelse ifølge krav 6, hvor koagulationsfaktoren er Faktor VII eller Faktor Vila.
10. Kimærisk protein til anvendelse ifølge et hvilket som helst af kravene 5 til 9 til anvendelse til behandling af et individ, der har en hæmostatisk forstyrrelse.
11. Kimærisk protein til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor proteinet i den første polypeptidkæde er et hormon.
12. Kimærisk protein til anvendelse ifølge krav 11, hvor hormonet er erythropoietin (EPO).
13. Kimærisk protein til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor proteinet i den første polypeptidkæde er et cytokin.
14. Kimærisk protein til anvendelse ifølge krav 13, hvor cytokinet er interferon-α eller interferon-β.
15. Kimærisk protein til anvendelse ifølge krav 13 eller krav 14 til anvendelse til behandling af en virusinfektion.
16. Kimærisk protein til anvendelse ifølge et hvilket som helst af kravene 1 til 15, hvor det kimæriske protein er til administration intravenøst, intramuskulært, subkutant, oralt, bukkalt, sublingualt, nasalt, parenteralt, rektalt, vaginalt, via en slimhindeoverflade, via en aerosol, eller via en pulmonal vej.
17. Farmaceutisk sammensætning til anvendelse i en fremgangsmåde til behandling, hvor den farmaceutiske sammensætning omfatter det kimæriske protein til anvendelse ifølge et hvilket som helst af kravene 1 til 16 og en farmaceutisk acceptabel excipiens.
18. Første polynukleotid, der koder for den første polypeptidkæde af det kimæriske protein til anvendelse ifølge et hvilket som helst af kravene 1 til 16, og et andet polynukleotid, der koder for den anden polypeptidkæde af det kimæriske protein.
19. Fremgangsmåde til fremstilling af det kimæriske protein til anvendelse ifølge et hvilket som helst af kravene 1 til 16, hvor fremgangsmåden omfatter: transfektion af en værtscelle med et første polynukleotid, der koder for den første polypeptidkæde, og et andet polynukleotid, der koder for den anden polypeptidkæde; dyrkning af cellen under forhold, således at den første og anden polypeptidkæde udtrykkes; og isolering af det kimæriske protein fra værtscellen.
DK10182890.3T 2003-05-06 2004-05-06 Kimære immunoglobulinmonomer-dimerhybrider DK2361932T3 (da)

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