DE69632538T2 - Neuartige lipolytische enzyme - Google Patents
Neuartige lipolytische enzyme Download PDFInfo
- Publication number
- DE69632538T2 DE69632538T2 DE69632538T DE69632538T DE69632538T2 DE 69632538 T2 DE69632538 T2 DE 69632538T2 DE 69632538 T DE69632538 T DE 69632538T DE 69632538 T DE69632538 T DE 69632538T DE 69632538 T2 DE69632538 T2 DE 69632538T2
- Authority
- DE
- Germany
- Prior art keywords
- enzyme
- lipolytic
- lipolytic enzyme
- parent
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- BKIFJPAJPVNRSG-UHFFFAOYSA-N oxolane-2,2,5,5-tetracarboxylic acid Chemical class OC(=O)C1(C(O)=O)CCC(C(O)=O)(C(O)=O)O1 BKIFJPAJPVNRSG-UHFFFAOYSA-N 0.000 description 1
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- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
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- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
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- 150000003904 phospholipids Chemical class 0.000 description 1
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- 238000011533 pre-incubation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 108010077112 prolyl-proline Proteins 0.000 description 1
- 108010004914 prolylarginine Proteins 0.000 description 1
- NJEVMKZODGWUQT-UHFFFAOYSA-N propane-1,1,3,3-tetracarboxylic acid Chemical class OC(=O)C(C(O)=O)CC(C(O)=O)C(O)=O NJEVMKZODGWUQT-UHFFFAOYSA-N 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
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- 150000004023 quaternary phosphonium compounds Chemical class 0.000 description 1
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
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- 238000009738 saturating Methods 0.000 description 1
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- 239000003352 sequestering agent Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000010563 solid-state fermentation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 108010079522 solysime Proteins 0.000 description 1
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- 238000012409 standard PCR amplification Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 229950009390 symclosene Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 108010075550 termamyl Proteins 0.000 description 1
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- 229960002180 tetracycline Drugs 0.000 description 1
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- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- JSPLKZUTYZBBKA-UHFFFAOYSA-N trioxidane Chemical compound OOO JSPLKZUTYZBBKA-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 101150016309 trpC gene Proteins 0.000 description 1
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 235000010447 xylitol Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK90595 | 1995-08-11 | ||
| DK90595 | 1995-08-11 | ||
| DK109695 | 1995-09-29 | ||
| DK109695 | 1995-09-29 | ||
| US1162796P | 1996-02-14 | 1996-02-14 | |
| DK37496 | 1996-04-01 | ||
| DK37496 | 1996-04-01 | ||
| US1675496P | 1996-05-07 | 1996-05-07 | |
| US16754P | 1996-05-07 | ||
| PCT/DK1996/000341 WO1997007202A1 (en) | 1995-08-11 | 1996-08-12 | Novel lipolytic enzymes |
| US11627P | 1997-06-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69632538D1 DE69632538D1 (de) | 2004-06-24 |
| DE69632538T2 true DE69632538T2 (de) | 2005-05-19 |
Family
ID=27512774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69632538T Expired - Lifetime DE69632538T2 (de) | 1995-08-11 | 1996-08-12 | Neuartige lipolytische enzyme |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0851913B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4068142B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1192780B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE267248T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU6655196A (cg-RX-API-DMAC7.html) |
| DE (1) | DE69632538T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2221934T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997007202A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (661)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936289B2 (en) | 1995-06-07 | 2005-08-30 | Danisco A/S | Method of improving the properties of a flour dough, a flour dough improving composition and improved food products |
| JP4290763B2 (ja) | 1996-04-30 | 2009-07-08 | ノボザイムス アクティーゼルスカブ | α―アミラーゼ変異体 |
| JPH11511780A (ja) * | 1996-05-15 | 1999-10-12 | ザ、プロクター、エンド、ギャンブル、カンパニー | 特定の脂肪分解酵素と石炭石鹸分散剤とを含んでなる洗剤組成物 |
| WO1997043380A1 (en) * | 1996-05-15 | 1997-11-20 | The Procter & Gamble Company | Detergent compositions comprising specific lipolytic enzyme and zeolite map |
| EP2278001B1 (en) | 1996-11-04 | 2013-10-23 | Novozymes A/S | Protease variants and compositions |
| TW524667B (en) | 1996-12-05 | 2003-03-21 | Pfizer | Parasiticidal pyrazoles |
| AU5187898A (en) | 1996-12-09 | 1998-07-03 | Novo Nordisk A/S | Reduction of phosphorus containing components in edible oils comprising a high amount of non-hydratable phosphorus by use of a phospholipase, a phospholipase from a filamentous fungus having phospholipase a and/or b activity |
| AU6820698A (en) | 1997-04-09 | 1998-10-30 | Danisco A/S | Improved method for preparing flour doughs and products made from such doughs using glycerol oxidase |
| DE19743683A1 (de) * | 1997-10-02 | 1999-04-08 | Basf Ag | Verfahren zur Änderung der Substratspezifität von Enzymen |
| KR20010015754A (ko) | 1997-10-13 | 2001-02-26 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | α-아밀라제 변이체 |
| CN1163597C (zh) | 1997-10-30 | 2004-08-25 | 诺维信公司 | α-淀粉酶突变体 |
| DE69837559T3 (de) * | 1997-12-24 | 2011-07-21 | Genencor International, Inc., Calif. | Verfahren zur Bestimmung der Waschleistung eines Enzyms. |
| AU3247699A (en) * | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| US6156552A (en) * | 1998-02-18 | 2000-12-05 | Novo Nordisk A/S | Lipase variants |
| WO2000005396A1 (en) | 1998-07-21 | 2000-02-03 | Danisco A/S | Foodstuff |
| US7312062B2 (en) | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| EP2290058A1 (en) | 1998-11-27 | 2011-03-02 | Novozymes A/S | Lipolytic enzyme variants |
| DE69943346D1 (de) | 1998-12-18 | 2011-05-19 | Novozymes As | Subtilase Enzyme der I-S1- und I-S2-Untergruppen mit einem zusätzlichen Aminosäurerest in einer aktiven Schleifenregion |
| MXPA01009700A (es) * | 1999-03-31 | 2002-05-14 | Novo Nordisk As | Variante de lipasa. |
| DK2011864T3 (en) | 1999-03-31 | 2015-04-07 | Novozymes As | Polypeptides with alkaline alpha-amylase activity and nucleic acids encoding them |
| JP4750284B2 (ja) | 1999-03-31 | 2011-08-17 | ノボザイムス アクティーゼルスカブ | アルカリα−アミラーゼ活性を有するポリペプチド及びそれらをコードする核酸 |
| DK1428874T3 (en) | 1999-03-31 | 2014-03-10 | Novozymes As | lipase variant |
| AU4392900A (en) | 1999-05-20 | 2000-12-12 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 127 and 128 |
| ATE408680T1 (de) | 1999-05-20 | 2008-10-15 | Novozymes As | Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 128 und 129 |
| WO2000071691A1 (en) | 1999-05-20 | 2000-11-30 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 125 and 126 |
| WO2000071687A1 (en) | 1999-05-20 | 2000-11-30 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 129 and 130 |
| EP1183340B1 (en) | 1999-05-20 | 2008-09-03 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 126 and 127 |
| ATE408676T1 (de) | 1999-05-20 | 2008-10-15 | Novozymes As | Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 132 und 133 |
| AU6820000A (en) | 1999-08-31 | 2001-03-26 | Novozymes A/S | Novel proteases and variants thereof |
| US6350599B1 (en) | 2000-01-12 | 2002-02-26 | Novozymes A/S | Pullulanase variants and methods for preparing such variants with predetermined properties |
| EP2221365A1 (en) | 2000-03-08 | 2010-08-25 | Novozymes A/S | Variants with altered properties |
| EP2258852A1 (en) | 2000-04-28 | 2010-12-08 | Novozymes A/S | Lipolytic enzyme variant |
| WO2002000852A2 (en) | 2000-06-26 | 2002-01-03 | Novozymes A/S | Lipolytic enzyme |
| EP2204446A1 (en) | 2000-08-01 | 2010-07-07 | Novozymes A/S | Alpha-amylase mutants with altered properties |
| AU2001279614B2 (en) | 2000-08-21 | 2006-08-17 | Novozymes A/S | Subtilase enzymes |
| EP1975229A3 (en) | 2000-10-13 | 2009-03-18 | Novozymes A/S | Alpha-amylase variant with altered properties |
| EP2333055A1 (en) | 2000-10-13 | 2011-06-15 | Novozymes A/S | Subtilase variants |
| ES2323947T3 (es) | 2001-01-10 | 2009-07-28 | Novozymes A/S | Variante de enzima lipolitica. |
| EP1360278B1 (en) | 2001-02-07 | 2009-09-23 | Novozymes A/S | Lipase variants |
| EP3000881A3 (en) | 2001-05-15 | 2016-07-20 | Novozymes A/S | Alpha-amylase variant with altered properties |
| CN100591212C (zh) | 2001-05-18 | 2010-02-24 | 丹尼斯科有限公司 | 改善生面团和面包质量的方法 |
| AU2002316809A1 (en) | 2001-06-26 | 2003-01-08 | Novozymes A/S | Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same |
| DK200101090A (da) | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
| AU2003203139B2 (en) | 2002-01-16 | 2007-11-08 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| JP2005520546A (ja) | 2002-03-27 | 2005-07-14 | ノボザイムス アクティーゼルスカブ | フィラメントコーティングを有する粒体 |
| EP1520012B1 (en) | 2002-07-01 | 2009-01-07 | Novozymes A/S | Monopropylene glycol added to fermentation |
| US7560260B2 (en) | 2002-07-25 | 2009-07-14 | Bio-Rad Laboratories, Inc. | Compositions with polymerase activity |
| ATE494368T1 (de) | 2002-10-01 | 2011-01-15 | Novozymes As | Polypeptide der gh-61-familie |
| CA2502304C (en) | 2002-10-08 | 2013-10-01 | Genencor International, Inc. | Phenolic binding peptides |
| TWI319007B (en) | 2002-11-06 | 2010-01-01 | Novozymes As | Subtilase variants |
| EP2128247A1 (en) | 2002-12-20 | 2009-12-02 | Novozymes A/S | Polypeptides having cellobiohydrolase II activity and polynucleotides encoding same |
| US20050196766A1 (en) | 2003-12-24 | 2005-09-08 | Soe Jorn B. | Proteins |
| MXPA05007654A (es) | 2003-01-17 | 2005-09-30 | Danisco | Metodo. |
| US7955814B2 (en) | 2003-01-17 | 2011-06-07 | Danisco A/S | Method |
| JP2006517990A (ja) | 2003-01-27 | 2006-08-03 | ノボザイムス アクティーゼルスカブ | 粒体の安定化 |
| EP1923455A3 (en) | 2003-02-18 | 2009-01-21 | Novozymes A/S | Detergent compositions |
| EP2228440B1 (en) | 2003-05-02 | 2012-08-22 | Novozymes Inc. | Variants of beta-glucosidases |
| DK1639106T3 (da) | 2003-06-19 | 2010-09-27 | Novozymes As | Proteaser |
| WO2005001064A2 (en) | 2003-06-25 | 2005-01-06 | Novozymes A/S | Polypeptides having alpha-amylase activity and polypeptides encoding same |
| EP1660637A4 (en) | 2003-08-25 | 2009-10-21 | Novozymes Inc | VARIANTS OF GLYCOSIDE HYDROLASES |
| CN1867668A (zh) | 2003-10-10 | 2006-11-22 | 诺维信公司 | 蛋白酶变体 |
| JP4880469B2 (ja) | 2003-10-23 | 2012-02-22 | ノボザイムス アクティーゼルスカブ | 洗剤中で改良された安定性を有するプロテアーゼ |
| ES2437198T3 (es) | 2003-10-28 | 2014-01-09 | Novozymes Inc. | Polipéptidos con actividad de beta-glucosidasa y polinucleótidos aislados que codifican los polipéptidos |
| US7514464B2 (en) | 2003-12-18 | 2009-04-07 | Pfizer Limited | Substituted arylpyrazoles |
| GB0329314D0 (en) | 2003-12-18 | 2004-01-21 | Pfizer Ltd | Substituted arylpyrazoles |
| US7718408B2 (en) | 2003-12-24 | 2010-05-18 | Danisco A/S | Method |
| WO2008090395A1 (en) | 2007-01-25 | 2008-07-31 | Danisco A/S | Production of a lipid acyltransferase from transformed bacillus licheniformis cells |
| GB0716126D0 (en) | 2007-08-17 | 2007-09-26 | Danisco | Process |
| US7906307B2 (en) | 2003-12-24 | 2011-03-15 | Danisco A/S | Variant lipid acyltransferases and methods of making |
| JP5059412B2 (ja) | 2004-01-06 | 2012-10-24 | ノボザイムス アクティーゼルスカブ | アリシクロバシラスｓｐ．のポリペプチド |
| EP2305703B1 (en) | 2004-01-30 | 2014-03-12 | Novozymes Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| EP1713919A2 (en) | 2004-02-13 | 2006-10-25 | Novozymes A/S | Protease variants |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2076939T3 (es) * | 1987-08-28 | 1995-11-16 | Novo Nordisk As | Lipasa recombinante de humicola y procedimiento para la produccion de lipasas recombinantes de humicola. |
| AU657278B2 (en) * | 1990-09-13 | 1995-03-09 | Novo Nordisk A/S | Lipase variants |
| GB9114734D0 (en) * | 1991-07-09 | 1991-08-28 | Univ London | Process for modifying proteins |
| GB9216387D0 (en) * | 1992-07-31 | 1992-09-16 | Unilever Plc | Enzymatic detergent compositions |
| CA2151038A1 (en) * | 1992-12-23 | 1994-07-07 | Maarten Robert Egmond | Modified cutinases, dna, vector and host |
-
1996
- 1996-08-12 AT AT96926323T patent/ATE267248T1/de not_active IP Right Cessation
- 1996-08-12 JP JP50884097A patent/JP4068142B2/ja not_active Expired - Fee Related
- 1996-08-12 CN CN96196233.XA patent/CN1192780B/zh not_active Expired - Fee Related
- 1996-08-12 AU AU66551/96A patent/AU6655196A/en not_active Abandoned
- 1996-08-12 DE DE69632538T patent/DE69632538T2/de not_active Expired - Lifetime
- 1996-08-12 EP EP96926323A patent/EP0851913B1/en not_active Expired - Lifetime
- 1996-08-12 WO PCT/DK1996/000341 patent/WO1997007202A1/en not_active Ceased
- 1996-08-12 ES ES96926323T patent/ES2221934T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6655196A (en) | 1997-03-12 |
| JP4068142B2 (ja) | 2008-03-26 |
| ATE267248T1 (de) | 2004-06-15 |
| DE69632538D1 (de) | 2004-06-24 |
| EP0851913B1 (en) | 2004-05-19 |
| ES2221934T3 (es) | 2005-01-16 |
| WO1997007202A1 (en) | 1997-02-27 |
| CN1192780A (zh) | 1998-09-09 |
| EP0851913A1 (en) | 1998-07-08 |
| CN1192780B (zh) | 2010-08-04 |
| JPH11510699A (ja) | 1999-09-21 |
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