CN1487967A - 一种制备胶原海绵的方法和用于萃取部分胶原泡沫的装置以及拉长的胶原海绵 - Google Patents
一种制备胶原海绵的方法和用于萃取部分胶原泡沫的装置以及拉长的胶原海绵 Download PDFInfo
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- CN1487967A CN1487967A CNA028040953A CN02804095A CN1487967A CN 1487967 A CN1487967 A CN 1487967A CN A028040953 A CNA028040953 A CN A028040953A CN 02804095 A CN02804095 A CN 02804095A CN 1487967 A CN1487967 A CN 1487967A
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/046—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00463—Plasters use haemostatic
- A61F2013/00472—Plasters use haemostatic with chemical means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
Description
循环1 | 循环2 | 循环3 | |
剥离腱:废物(%) | 24 | 40 | 38 |
剥离前的生物负荷CFU/g腱 | 7×104 | 2.4×105 | 5×105 |
剥离后的生物负荷(CFU/g腱) | - | 2×103 | 5×103 |
每批腱重量 | 12.00kg | 10.5kg | 10.5kg |
用除离子水洗涤剥离腱 | 30min | 30min | 30min |
除去可溶蛋白:用除离子水洗涤切断的腱直到洗涤溶液不含血红蛋白 | 5h | 5h | 1.5h |
用70%乙醇消毒 | 15min | 15min | 15min |
在0.45%乳酸中洗涤 | 21min | 21min | 21min |
在0.45%乳酸中浸泡 | 144h | 120h | 120h |
均化 | Condux齿条式盘磨机 | Condux齿条式盘磨机 | Condux齿条式盘磨机 |
凝胶粘度(转矩) | 6.9-7.8Ncm | 6.9-7.8Ncm | 7.1-9.5Ncm |
胶原凝胶干燥重量 | 6.3-8.3mg/g | 8.9-9.4mg/g | 7.8-9.4mg/g |
每块的起泡时间 | 37-47min | 51-58min | 54-62min |
生物负荷(CFU/ml湿的泡沫) | - | 2 | 1 |
排放时间 | 18.5h | 22h | 18h |
中和时间 | 24h | 24h | 24.5h |
干燥时间 | 147h | 148.5h | 144.5h |
每块重量 | 200-256g | 195-228g | 177-257g |
腾腾海绵条带的生物负荷(CFU/g) | 14-1000 | <18-124 | <11-33 |
胶原海绵条带的收率:长度:110mm宽度:500mm高度:4-7mm重量:770-1500mg/条带 | 405 | 379 | 433 |
海绵I | 海绵II | 海绵III | |
pH值(spec:4-6) | 5.4 | 5.1 | 5.4 |
乳酸含量 | 2.6% | 2.8% | 2% |
铵含量 | 0.2% | 0.2% | 0.1% |
可溶蛋白含量 | 0.1% | 0.05% | 0.08% |
硫酸盐灰分含量 | 0.4% | 0.3% | 0.3% |
微生物纯度(CFU/g) | 14-1000 | <18-124 | <11-33 |
胶原含量(干燥重量) | 95% | 95% | 98% |
水分含量 | 14% | 15% | 16% |
弹性模量 | 10-45N/cm | 15-50N/cm | 12.3-41.0N/cm |
腔尺寸(直径,平均值) | 2.3mm | 2.1mm | 2.9mm |
密度 | 2.5-6.1mg/cm3 | 2.9-5.9mg/cm3 | 2.4-5.0mg/cm3 |
海绵IV | 海绵V | ||
pH值 | 5.3 | 5.7 | |
乳酸含量 | 2.3% | 1.1% | |
铵含量 | 0.1% | 0.1% | |
可溶蛋白含量 | 0.04% | 0.11% | |
硫酸盐灰分含量 | 0.3% | 0.2% | |
重金属含量 | <20ppm | <20ppm | |
微生物纯度(CFU/g) | <12-345 | <15-48 | |
胶原含量(干燥重量) | 95% | 96% | |
水分含量 | 14% | 12% | |
弹性模量 | 10.4-42.1N/cm | 20-47N/cm | |
腔尺寸(直径,平均值) | 2.9mm | 2.5mm | |
密度 | 2.9-5.3mg/cm3 | 2-6.8mg/cm3 |
Claims (41)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100135 | 2001-01-25 | ||
DKPA200100135 | 2001-01-25 | ||
DKPA200100235 | 2001-02-13 | ||
DKPA200100235 | 2001-02-13 |
Publications (2)
Publication Number | Publication Date |
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CN1487967A true CN1487967A (zh) | 2004-04-07 |
CN1290907C CN1290907C (zh) | 2006-12-20 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CNB028040953A Expired - Lifetime CN1290907C (zh) | 2001-01-25 | 2002-01-25 | 一种制备胶原海绵的方法和用于萃取部分胶原泡沫的装置以及拉长的胶原海绵 |
CNB028040961A Expired - Lifetime CN1264578C (zh) | 2001-01-25 | 2002-01-25 | 具有固体纤维蛋白原和固体凝血酶的载体 |
CNB02804097XA Expired - Fee Related CN1246047C (zh) | 2001-01-25 | 2002-01-25 | 含纤维蛋白原、凝血酶和醇的悬浮液及其涂敷载体的方法 |
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CNB028040961A Expired - Lifetime CN1264578C (zh) | 2001-01-25 | 2002-01-25 | 具有固体纤维蛋白原和固体凝血酶的载体 |
CNB02804097XA Expired - Fee Related CN1246047C (zh) | 2001-01-25 | 2002-01-25 | 含纤维蛋白原、凝血酶和醇的悬浮液及其涂敷载体的方法 |
Country Status (37)
Country | Link |
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EP (4) | EP1343542B1 (zh) |
JP (4) | JP2004521115A (zh) |
KR (2) | KR100830294B1 (zh) |
CN (3) | CN1290907C (zh) |
AR (3) | AR032517A1 (zh) |
AT (2) | ATE310044T1 (zh) |
AU (3) | AU2002307809B2 (zh) |
BG (3) | BG66439B1 (zh) |
BR (3) | BRPI0206708B8 (zh) |
CA (3) | CA2435159C (zh) |
CL (1) | CL2015003111A1 (zh) |
CR (1) | CR7034A (zh) |
CZ (3) | CZ305120B6 (zh) |
DE (2) | DE60203364T2 (zh) |
DK (2) | DK1343542T3 (zh) |
EA (4) | EA006540B1 (zh) |
EE (3) | EE05587B1 (zh) |
EG (2) | EG26417A (zh) |
ES (2) | ES2253523T3 (zh) |
HK (2) | HK1058371A1 (zh) |
HR (1) | HRP20030648B1 (zh) |
HU (3) | HU228810B1 (zh) |
IL (6) | IL157096A0 (zh) |
IS (1) | IS6885A (zh) |
ME (1) | ME00587A (zh) |
MX (3) | MXPA03006688A (zh) |
NO (3) | NO327386B1 (zh) |
NZ (3) | NZ527165A (zh) |
PL (3) | PL205181B1 (zh) |
PT (1) | PT1343542E (zh) |
RS (1) | RS50866B (zh) |
SI (2) | SI1343542T1 (zh) |
SK (3) | SK10342003A3 (zh) |
TW (2) | TWI237573B (zh) |
UA (1) | UA73028C2 (zh) |
UY (1) | UY27136A1 (zh) |
WO (3) | WO2002070594A2 (zh) |
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WO2013013537A1 (zh) | 2011-07-28 | 2013-01-31 | Wang Shanshan | 一种复合胶原蛋白海绵及其制备方法 |
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