CN1507358A - 具有固体纤维蛋白原和固体凝血酶的载体 - Google Patents
具有固体纤维蛋白原和固体凝血酶的载体 Download PDFInfo
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- CN1507358A CN1507358A CNA028040961A CN02804096A CN1507358A CN 1507358 A CN1507358 A CN 1507358A CN A028040961 A CNA028040961 A CN A028040961A CN 02804096 A CN02804096 A CN 02804096A CN 1507358 A CN1507358 A CN 1507358A
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Abstract
Description
实施例 | I | II | III |
pH值 | 5.3 | 5.1 | 5.4 |
乳酸含量 | 2.3% | 2.8% | 2% |
铵含量 | 0.1% | 0.2% | 0.1% |
可溶蛋白含量 | 0.04% | 0.05% | 0.08% |
硫酸盐灰分含量 | 0.3% | 0.3% | 0.3% |
微生物纯度(CFU/g) | <12-345 | <18-124 | <11-33 |
水含量 | 14% | 15% | 16% |
胶原含量(干重) | 95% | 95% | 98% |
弹性模量 | 10.4-42.1N/cm | 15-50N/cm | 12.3-41.0N/c |
孔径尺寸(直径,平均值) | 2.9mm | 2.1mm | 2.9mm |
密度 | 2.9-5.3mg/cm3 | 2.9-5.9mg/cm3 | 2.4-5.0mg/cm3 |
图1 |
1.1 Opraskin:未涂层的/涂层的 |
1.2 涂层的Opraskin:插入到内窥镜检查设备中 |
1.3 涂层的Opraskin:在前插入到内窥镜检查设备中展开。 |
图2 |
2.1 Willospon forte:未涂层的/涂层的 |
2.2 涂层的Willospon forte:插入到内窥镜检查设备中 |
2.3 涂层的Willospon forte在插入到内窥镜检查设备中前展开。 |
图3 |
3.1 Willospon Spezial:未涂层的/涂层的 |
3.2 涂层的Willospon Spezial:插入到内窥镜检查设备中 |
3.3 涂层的Willospon Spezial在插入到内窥镜检查设备中前展开。 |
图4 |
4.1 Ethisorb药膏:未涂层的/涂层的 |
4.2 涂层的Ethisorb药膏:插入到内窥镜检查设备中 |
4.3 涂层的Ethisorb药膏在插入到内窥镜检查设备中前展开。 |
图5 |
5.1 TabotampNU Knit:未涂层的/涂层的 |
5.2 涂层的Tabotamp NU Knit:插入到内窥镜检查设备中 |
5.3 涂层的Tabotamp NU Knit:在插入到内窥镜检查设备中前展开。 |
图6 |
6.1 海绵Nycomed:未涂层的/涂层的[实验室样品] |
6.2 涂层的海绵Nycomed[实验室样品]:插入到内窥镜检查设备中 |
6.3 涂层的胶原海绵Nycomed[实验室样品]:在插入到内窥镜检查设备中前展开。 |
图7 |
内窥镜检查工具:Endodock |
内窥镜检查工具:Endodock |
内窥镜检查工具:Endodock |
图8 |
血液凝结物和凝块和载体药膏。所述载体涂层的活性成分如阴影框所示。 |
成分 | 总物质% | ||
配方A | 配方B | 配方C | |
人体纤维蛋白原 | 36-52 | 42-47 | 36-52 |
人体白蛋白 | 16-24 | 20-24 | 16-24 |
总蛋白质 | 52-76 | 62-71 | 52-76 |
氯化钠 | 8-14 | 0 | 8-14 |
柠檬酸三钠 | 2-4 | 1-3 | 2-4 |
精氨酸(盐酸) | 15-26 | 15-21 | 15-26 |
氨基乙酸 | 0 | 6-9 | 1-2 |
组氨酸 | 0 | 3-5 | 0 |
蔗糖 | 0 | 0 | 1-2 |
残留水分 | ≤2 | 2-4 | ≤1.5 |
配方 | 活性(I.U./mg物质) | 残余水分 | 附加物质添加剂 |
人体凝血酶A | 360-540 | ≤3% | 人体白蛋白,氯化钠,柠檬酸钠 |
人体凝血酶B | 7-10 | ≤3% | 人体白蛋白,氯化钠,柠檬酸钠 |
人体凝血酶C | 35-60 | ≤3% | 人体白蛋白,氯化钠,乙酸钠,氨基乙酸 |
商标 | 材料 | 由...制造/分布 |
Opraskin | 胶原海绵 | Lohmann,Postfach 2343,D-56513 Neuwied |
Willospon forte | 胶原海绵(小牛) | Will-Pharma,Postbus 30,NL1160 AA Zwanenburg |
WillosponSpezial | 胶质海绵 | Will-Pharma,Postbus 30,NL 1160 AA Zwanenburg |
Ethisorb 药膏 | Polyglactin910/Polydioxanon | Johnson/Johnson(manufacturer)Ethicon,Robert-Koch-Str.1D-22851 Norderstedt |
Tabotamp NUKnit | 氧化再生纤维素 | Johnson/Johnson(manufacturer)Ethicon,Robert-Koch-Str.1D-22851 Norderstedt |
胶原海绵Nycomed | 马的胶原海绵 | Nycomed AustriaSankt-Peter-Str.25A-4021 LINZ |
载体 | 物质 | 磨损(mg/cm2) |
Opraskin | 冻干胶原 | 2,1 |
Willospon forte(3mm) | 冻干胶原 | 1,2 |
Willospon Spezial(1mm) | 胶质 | 2,1 |
Ethisorb 药膏(ZVP609) | Polyglactin/dioxanon | 14,3 |
TabotampNU Knit | 氧化纤维素 | 9,2 |
胶原海绵 Nycomed | 胶原,泡沫状 | 0,15 |
载体 | 物质 | 弹性系数 |
Opraskin | 冻干胶原 | 1,78 |
Willospon forte(3mm) | 冻干胶原 | 1,53 |
Willospon Spezial(1mm) | 胶质 | 1,79 |
Ethisorb 药膏(ZVP609) | Polyglactin/dioxanon | 1,0 |
Tabotamp NU Knit | 氧化纤维素 | 1,15 |
胶原海绵Nycomed | 胶原,泡沫状 | 1,55 |
载体 | 物质 |
Opraskin | 冻干胶原 |
Willospon forte(3mm) | 冻干胶原 |
Willospon Spezial(1mm) | 胶质 |
Ethisorb 药膏(ZVP609) | Polyglactin/dioxanon |
Tabotamp NU Knit | 氧化纤维素 |
胶原海绵Nycomed | 胶原,泡沫状 |
Opraskin | 30-40% |
Willospon forte(3mm) | 60-70% |
Willospon Spezial(1mm) | 50% |
Tabotamp NU Knit | 60-70% |
Ethisorb 药膏 | 95% |
胶原海绵Nycomed | <5% |
所述层组合物 | 粘合强度(平均值±SD) | ||
纤维蛋白原mg/cm2 | 凝血酶,IU/cm2 | 在鼠肝上的抗张强度,N/cm2n=5 | 在鼠肾中对抗提高组织压力的粘合强度,mbarn=5 |
0 | 0 | 0.20±0.02 | 47±9 |
0 | 2.40 | 0.20±0.03 | 63±16 |
1.30 | 1.73 | 0.30±0.06 | 81±12 |
2.92 | 1.85 | 0.39±0.05 | 101±13 |
5.10 | 1.87 | 0.39±0.03 | 110±13 |
7.22 | 1.82 | 0.38±0.02 | 97±13 |
10.02 | 1.75 | 0.40±0.07 | 87±10 |
所述层组合物 | 粘合强度(平均值±SD) | ||
纤维蛋白原mg/cm2 | 凝血酶,IU/cm2 | 在鼠肝上的抗张强度,N/cm2 n=5 | 在鼠肾中对抗提高组织压力的粘合强度,mbar n=5 |
0 | 0 | 0.20±0.02 | 47±9 |
6.15 | 0 | 0.27±0.01 | 57±10 |
4.72 | 0.92 | 0.39±0.02 | 84±9 |
5.10 | 1.87 | 0.39±0.03 | 110±13 |
4.78 | 4.95 | 0.35±0.02 | 97±9 |
4.70 | 9.63 | 0.30±0.02 | 109±13 |
4.75 | 19.83 | 0.27±0.03 | 91±20 |
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TWI401097B (zh) * | 2004-10-20 | 2013-07-11 | Ethicon Inc | 強化之可吸收性多層止血傷口敷料及製造方法 |
US9358318B2 (en) | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
US9439997B2 (en) | 2004-10-20 | 2016-09-13 | Ethicon, Inc. | Reinforced absorbable multilayered hemostatis wound dressing |
CN104271164A (zh) * | 2012-05-14 | 2015-01-07 | 帝人株式会社 | 片成形体和止血材料 |
CN106267328A (zh) * | 2016-09-20 | 2017-01-04 | 安徽思维特生物科技有限公司 | 一种聚己内酯‑胎牛皮胶原纤维复合止血凝胶的制备方法 |
CN106267328B (zh) * | 2016-09-20 | 2019-04-12 | 安徽思维特生物科技有限公司 | 一种聚己内酯-胎牛皮胶原纤维复合止血凝胶的制备方法 |
CN106730031A (zh) * | 2016-12-30 | 2017-05-31 | 清华大学 | 一种用于脊髓损伤修复的仿生纤维蛋白水凝胶束及其制备方法 |
CN114177346A (zh) * | 2021-12-24 | 2022-03-15 | 中国人民解放军军事科学院军事医学研究院 | 一种止血组合物及止血贴与其应用 |
CN114246974A (zh) * | 2021-12-24 | 2022-03-29 | 中国人民解放军军事科学院军事医学研究院 | 一种止血贴的制备方法 |
CN114246974B (zh) * | 2021-12-24 | 2023-11-03 | 中国人民解放军军事科学院军事医学研究院 | 一种止血贴的制备方法 |
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