CA2237005C - Quinazoline derivatives - Google Patents

Quinazoline derivatives Download PDF

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Publication number
CA2237005C
CA2237005C CA002237005A CA2237005A CA2237005C CA 2237005 C CA2237005 C CA 2237005C CA 002237005 A CA002237005 A CA 002237005A CA 2237005 A CA2237005 A CA 2237005A CA 2237005 C CA2237005 C CA 2237005C
Authority
CA
Canada
Prior art keywords
methoxy
quinazoline
chloro
hydroxy
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002237005A
Other languages
English (en)
French (fr)
Other versions
CA2237005A1 (en
Inventor
Jean-Jacques Marcel Lohmann
Laurent Francois Andre Hennequin
Andrew Peter Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26140602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2237005(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Publication of CA2237005A1 publication Critical patent/CA2237005A1/en
Application granted granted Critical
Publication of CA2237005C publication Critical patent/CA2237005C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
CA002237005A 1995-12-18 1996-12-13 Quinazoline derivatives Expired - Fee Related CA2237005C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP95402846 1995-12-18
EP96402190 1996-10-15
EP95402846.0 1996-10-15
EP96402190.1 1996-10-15
PCT/GB1996/003075 WO1997022596A1 (en) 1995-12-18 1996-12-13 Quinazoline derivatives

Publications (2)

Publication Number Publication Date
CA2237005A1 CA2237005A1 (en) 1997-06-26
CA2237005C true CA2237005C (en) 2006-03-14

Family

ID=26140602

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002237005A Expired - Fee Related CA2237005C (en) 1995-12-18 1996-12-13 Quinazoline derivatives

Country Status (29)

Country Link
US (4) US5962458A (enExample)
EP (1) EP0873319B1 (enExample)
JP (1) JP4291413B2 (enExample)
KR (1) KR100530311B1 (enExample)
CN (1) CN1133625C (enExample)
AT (1) ATE203524T1 (enExample)
AU (1) AU712370B2 (enExample)
BR (1) BR9612043A (enExample)
CA (1) CA2237005C (enExample)
CZ (1) CZ291100B6 (enExample)
DE (1) DE69614147T2 (enExample)
DK (1) DK0873319T3 (enExample)
ES (1) ES2162656T3 (enExample)
GB (1) GB9624482D0 (enExample)
GR (1) GR3036954T3 (enExample)
HU (1) HUP9901243A3 (enExample)
IL (1) IL124925A0 (enExample)
MX (1) MX9804247A (enExample)
MY (1) MY132405A (enExample)
NO (1) NO311358B1 (enExample)
NZ (1) NZ324007A (enExample)
PL (1) PL192309B1 (enExample)
PT (1) PT873319E (enExample)
RU (1) RU2194701C2 (enExample)
SI (1) SI0873319T1 (enExample)
SK (1) SK282443B6 (enExample)
TR (1) TR199801115T2 (enExample)
TW (1) TW411274B (enExample)
WO (1) WO1997022596A1 (enExample)

Families Citing this family (580)

* Cited by examiner, † Cited by third party
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CA2237005A1 (en) 1997-06-26
CZ291100B6 (cs) 2002-12-11
SI0873319T1 (en) 2002-02-28
DK0873319T3 (da) 2001-10-22
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HUP9901243A3 (en) 2001-11-28
BR9612043A (pt) 1999-12-28
MY132405A (en) 2007-10-31
US6258951B1 (en) 2001-07-10
WO1997022596A1 (en) 1997-06-26
EP0873319A1 (en) 1998-10-28
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NO982784L (no) 1998-08-17
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AU712370B2 (en) 1999-11-04
TW411274B (en) 2000-11-11
US20020032208A1 (en) 2002-03-14
PL327310A1 (en) 1998-12-07
DE69614147T2 (de) 2002-03-21
ATE203524T1 (de) 2001-08-15
IL124925A0 (en) 1999-01-26
DE69614147D1 (de) 2001-08-30
TR199801115T2 (xx) 1998-08-21
EP0873319B1 (en) 2001-07-25
CZ188298A3 (cs) 1998-09-16
KR20000064455A (ko) 2000-11-06
SK282443B6 (sk) 2002-02-05
NO311358B1 (no) 2001-11-19
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US6362336B1 (en) 2002-03-26
HUP9901243A2 (hu) 1999-08-30
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US5962458A (en) 1999-10-05
SK82898A3 (en) 1998-11-04
NO982784D0 (no) 1998-06-17
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PL192309B1 (pl) 2006-09-29

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