TWI750110B - 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 - Google Patents

使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 Download PDF

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TWI750110B
TWI750110B TW104123636A TW104123636A TWI750110B TW I750110 B TWI750110 B TW I750110B TW 104123636 A TW104123636 A TW 104123636A TW 104123636 A TW104123636 A TW 104123636A TW I750110 B TWI750110 B TW I750110B
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seq
amino acid
acid sequence
bcma
sequence
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TW104123636A
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TW201615832A (zh
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珍妮佛 布拉格登
優吉妮 崔
希爾瑪 愛伯斯巴赫
大衛 葛雷斯
希兒樂 惠特
卡爾 君
瓊安 曼尼克
麥克 米隆
里昂 墨菲
蓋伯拉 普莉莎
瑟雷斯特 理查德森
瑪寇 魯拉
瑞許瑪 星
王永強
期隆 吳
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瑞士商諾華公司
賓夕法尼亞大學董事會
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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TW104123636A 2014-07-21 2015-07-21 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 TWI750110B (zh)

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Application Number Priority Date Filing Date Title
CN2014082586 2014-07-21
WOPCT/CN2014/082586 2014-07-21
CN2014090501 2014-11-06
WOPCT/CN2014/090501 2014-11-06

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US (3) US10174095B2 (cg-RX-API-DMAC7.html)
EP (1) EP3172237A2 (cg-RX-API-DMAC7.html)
JP (2) JP7054622B2 (cg-RX-API-DMAC7.html)
KR (1) KR102612313B1 (cg-RX-API-DMAC7.html)
CN (1) CN106687483B (cg-RX-API-DMAC7.html)
AU (2) AU2015292744C1 (cg-RX-API-DMAC7.html)
BR (1) BR112017001183A2 (cg-RX-API-DMAC7.html)
CO (1) CO2017000507A2 (cg-RX-API-DMAC7.html)
IL (1) IL250043B (cg-RX-API-DMAC7.html)
MX (1) MX2017001011A (cg-RX-API-DMAC7.html)
MY (1) MY181834A (cg-RX-API-DMAC7.html)
RU (1) RU2751660C2 (cg-RX-API-DMAC7.html)
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