SK286635B6 - N-substituované 2-kyanopyrolidíny, farmaceutický prostriedok, ktorý ich obsahuje a ich použitie na výrobu liečiva - Google Patents
N-substituované 2-kyanopyrolidíny, farmaceutický prostriedok, ktorý ich obsahuje a ich použitie na výrobu liečiva Download PDFInfo
- Publication number
- SK286635B6 SK286635B6 SK789-2001A SK7892001A SK286635B6 SK 286635 B6 SK286635 B6 SK 286635B6 SK 7892001 A SK7892001 A SK 7892001A SK 286635 B6 SK286635 B6 SK 286635B6
- Authority
- SK
- Slovakia
- Prior art keywords
- amino
- acetyl
- adamantyl
- cyanopyrrolidine
- pharmaceutically acceptable
- Prior art date
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- -1 N-substituted 2-cyanopyrrolidines Chemical class 0.000 title claims abstract description 21
- 150000003839 salts Chemical group 0.000 claims abstract description 40
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims abstract description 34
- 239000002253 acid Substances 0.000 claims abstract description 28
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 20
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract description 10
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- 230000000949 anxiolytic effect Effects 0.000 claims abstract description 3
- 206010003246 arthritis Diseases 0.000 claims abstract description 3
- 230000001925 catabolic effect Effects 0.000 claims abstract description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract description 3
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- VDWAERFKLOEGKY-YYSDWXCKSA-N (2s)-1-[2-[(3-ethoxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile Chemical compound C1C(OCC)(C2)CC(C3)CC2CC31NCC(=O)N1CCC[C@H]1C#N VDWAERFKLOEGKY-YYSDWXCKSA-N 0.000 claims 1
- MYRHWSMCJJPYDN-FMVYEHJMSA-N (2s)-1-[2-[(3-methoxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile Chemical compound C1C(OC)(C2)CC(C3)CC2CC31NCC(=O)N1CCC[C@H]1C#N MYRHWSMCJJPYDN-FMVYEHJMSA-N 0.000 claims 1
- ZHUTVLURGLOKMO-UHFFFAOYSA-N 1-acetylpyrrolidine-2-carbonitrile Chemical compound CC(=O)N1CCCC1C#N ZHUTVLURGLOKMO-UHFFFAOYSA-N 0.000 claims 1
- ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical group CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
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- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
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- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20906898A | 1998-12-10 | 1998-12-10 | |
PCT/EP1999/009708 WO2000034241A1 (en) | 1998-12-10 | 1999-12-09 | N-substituted 2-cyanopyrrolidines |
Publications (2)
Publication Number | Publication Date |
---|---|
SK7892001A3 SK7892001A3 (en) | 2001-11-06 |
SK286635B6 true SK286635B6 (sk) | 2009-02-05 |
Family
ID=22777194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK789-2001A SK286635B6 (sk) | 1998-12-10 | 1999-12-09 | N-substituované 2-kyanopyrolidíny, farmaceutický prostriedok, ktorý ich obsahuje a ich použitie na výrobu liečiva |
Country Status (34)
Country | Link |
---|---|
US (1) | US6166063A (nl) |
EP (1) | EP1137635B1 (nl) |
JP (2) | JP3681110B2 (nl) |
KR (2) | KR100509311B1 (nl) |
CN (1) | CN1160330C (nl) |
AR (1) | AR023719A1 (nl) |
AT (1) | ATE307112T1 (nl) |
BR (1) | BRPI9915985B8 (nl) |
CA (1) | CA2350609C (nl) |
CO (1) | CO5150173A1 (nl) |
CY (3) | CY1105355T1 (nl) |
CZ (1) | CZ299151B6 (nl) |
DE (3) | DE122008000017I1 (nl) |
DK (1) | DK1137635T3 (nl) |
ES (1) | ES2251847T3 (nl) |
FR (1) | FR08C0005I2 (nl) |
HK (1) | HK1040394B (nl) |
HU (1) | HU226769B1 (nl) |
ID (1) | ID28796A (nl) |
IL (2) | IL143091A0 (nl) |
LU (2) | LU91409I2 (nl) |
MY (1) | MY123244A (nl) |
NL (2) | NL300333I2 (nl) |
NO (3) | NO318741B1 (nl) |
NZ (1) | NZ511935A (nl) |
PE (1) | PE20001317A1 (nl) |
PL (1) | PL199443B1 (nl) |
RU (1) | RU2251544C2 (nl) |
SK (1) | SK286635B6 (nl) |
TR (1) | TR200101478T2 (nl) |
TW (1) | TW509674B (nl) |
UY (1) | UY25843A1 (nl) |
WO (1) | WO2000034241A1 (nl) |
ZA (1) | ZA200104581B (nl) |
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