PE20001317A1 - N-(glicilo sustituido)-2-cianopirrolidinas como inhibidores de dpp-iv - Google Patents

N-(glicilo sustituido)-2-cianopirrolidinas como inhibidores de dpp-iv

Info

Publication number
PE20001317A1
PE20001317A1 PE1999001213A PE00121399A PE20001317A1 PE 20001317 A1 PE20001317 A1 PE 20001317A1 PE 1999001213 A PE1999001213 A PE 1999001213A PE 00121399 A PE00121399 A PE 00121399A PE 20001317 A1 PE20001317 A1 PE 20001317A1
Authority
PE
Peru
Prior art keywords
alkyl
cyanopyrrolidines
dpp
adamantil
pyrrolidine
Prior art date
Application number
PE1999001213A
Other languages
English (en)
Inventor
Edwin Bernard Villhauer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22777194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20001317(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20001317A1 publication Critical patent/PE20001317A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO N-(GLICILO SUSTITUIDO)-2-CIANOPIRROLIDINAS DE FORMULA I, DONDE: R ES ADAMANTILO; n ES 0-3, DE PREFERENCIA EL COMPUESTO IA O IB, R` ES OH, ALCOXILO C1-C7, ALCANOILOXILO C1-C8, R5R4N-COO; R4 Y R5 SON ALQUILO C1-C7, FENILO OPCIONALMENTE SUSTITUIDO POR ALQUILO C1-C7, ALCOXILO C1-C7, HALOGENO, TRIFLUOROMETILO; R4 ES H; O R4 Y R5 SON ALQUILENO C3-C6; R" ES H; R' Y R" SON ALQUILO C1-C7. SON COMPUESTOS PREFERIDOS (S)-1-[[(3,5-DIMETIL-1-ADAMANTIL)-AMINO]ACETIL]-2-CIANO-PIRROLIDINA, (S)-1-[[(3-ETIL-1-ADAMANTIL)AMINO]ACETIL]-2-CIANO-PIRROLIDINA, (S)-1-[(3-HIDROXI-1-ADAMANTIL)AMINO]ACETIL-2-CIANO-PIRROLIDINA, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE LA PEPTIDASA DE DIPEPTIDILO IV (DPP-IV) POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE LA DIABETES, OBESIDAD
PE1999001213A 1998-12-10 1999-12-07 N-(glicilo sustituido)-2-cianopirrolidinas como inhibidores de dpp-iv PE20001317A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20906898A 1998-12-10 1998-12-10

Publications (1)

Publication Number Publication Date
PE20001317A1 true PE20001317A1 (es) 2000-12-13

Family

ID=22777194

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001213A PE20001317A1 (es) 1998-12-10 1999-12-07 N-(glicilo sustituido)-2-cianopirrolidinas como inhibidores de dpp-iv

Country Status (34)

Country Link
US (1) US6166063A (es)
EP (1) EP1137635B1 (es)
JP (2) JP3681110B2 (es)
KR (2) KR100509311B1 (es)
CN (1) CN1160330C (es)
AR (1) AR023719A1 (es)
AT (1) ATE307112T1 (es)
BR (1) BRPI9915985B8 (es)
CA (1) CA2350609C (es)
CO (1) CO5150173A1 (es)
CY (3) CY1105355T1 (es)
CZ (1) CZ299151B6 (es)
DE (3) DE122008000017I1 (es)
DK (1) DK1137635T3 (es)
ES (1) ES2251847T3 (es)
FR (1) FR08C0005I2 (es)
HK (1) HK1040394B (es)
HU (1) HU226769B1 (es)
ID (1) ID28796A (es)
IL (2) IL143091A0 (es)
LU (2) LU91409I2 (es)
MY (1) MY123244A (es)
NL (2) NL300333I2 (es)
NO (3) NO318741B1 (es)
NZ (1) NZ511935A (es)
PE (1) PE20001317A1 (es)
PL (1) PL199443B1 (es)
RU (1) RU2251544C2 (es)
SK (1) SK286635B6 (es)
TR (1) TR200101478T2 (es)
TW (1) TW509674B (es)
UY (1) UY25843A1 (es)
WO (1) WO2000034241A1 (es)
ZA (1) ZA200104581B (es)

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