UY25843A1 - Compuestos orgánicos inhibidores de peptidasa de dipeptidilo-iv - Google Patents

Compuestos orgánicos inhibidores de peptidasa de dipeptidilo-iv

Info

Publication number
UY25843A1
UY25843A1 UY25843A UY25843A UY25843A1 UY 25843 A1 UY25843 A1 UY 25843A1 UY 25843 A UY25843 A UY 25843A UY 25843 A UY25843 A UY 25843A UY 25843 A1 UY25843 A1 UY 25843A1
Authority
UY
Uruguay
Prior art keywords
salts
dpp
dipeptidyl
compounds
formula
Prior art date
Application number
UY25843A
Other languages
English (en)
Inventor
Edwin Bernard Villhauer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22777194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY25843(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY25843A1 publication Critical patent/UY25843A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a novedosas N-(glicilo sustituido)-2-cianopirrolidinas de la fórmula (I) en donde R es adamantilo sustituido; y n es de 0 a 3; en forma libre o en forma de sal de adición de ácido. Se prefieren las sales farmacéuticamente aceptables, aunque también son útiles otras sales, por ejemplo en el aislamiento o en la purificación de los compuestos de esta invención. Aunque las sales de adición preferidas son los clorhidratos, también se pueden utilizar sales de ácido metansulfónico, sulfúrico, fosfórico, cítrico, láctico y acético. Por ejemplo: (S)-1-(((3,5-dimetil-1-adamantil)amino)-acetil)-2-ciano-pirrolidina. Los compuestos de la fórmula (I) inhiben la actividad de DPP-IV (peptidasa de dipeptidilo-IV). Por consiguiente, se indican para utilizarse como productos farmacéuticos en la inhibición de DPP-IV, y en el tratamiento de condiciones mediadas por DPP-IV, tales como diabetes melitus no dependiente de insulina, artritis, obesidad, osteoporosis, y otras condiciones de tolerancia deteriorada a la glucosa.
UY25843A 1998-12-10 1999-12-10 Compuestos orgánicos inhibidores de peptidasa de dipeptidilo-iv UY25843A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20906898A 1998-12-10 1998-12-10

Publications (1)

Publication Number Publication Date
UY25843A1 true UY25843A1 (es) 2001-08-27

Family

ID=22777194

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25843A UY25843A1 (es) 1998-12-10 1999-12-10 Compuestos orgánicos inhibidores de peptidasa de dipeptidilo-iv

Country Status (34)

Country Link
US (1) US6166063A (es)
EP (1) EP1137635B1 (es)
JP (2) JP3681110B2 (es)
KR (2) KR100509311B1 (es)
CN (1) CN1160330C (es)
AR (1) AR023719A1 (es)
AT (1) ATE307112T1 (es)
BR (1) BRPI9915985B8 (es)
CA (1) CA2350609C (es)
CO (1) CO5150173A1 (es)
CY (3) CY1105355T1 (es)
CZ (1) CZ299151B6 (es)
DE (3) DE122008000007I1 (es)
DK (1) DK1137635T3 (es)
ES (1) ES2251847T3 (es)
FR (1) FR08C0005I2 (es)
HK (1) HK1040394B (es)
HU (1) HU226769B1 (es)
ID (1) ID28796A (es)
IL (2) IL143091A0 (es)
LU (2) LU91409I2 (es)
MY (1) MY123244A (es)
NL (2) NL300333I2 (es)
NO (3) NO318741B1 (es)
NZ (1) NZ511935A (es)
PE (1) PE20001317A1 (es)
PL (1) PL199443B1 (es)
RU (1) RU2251544C2 (es)
SK (1) SK286635B6 (es)
TR (1) TR200101478T2 (es)
TW (1) TW509674B (es)
UY (1) UY25843A1 (es)
WO (1) WO2000034241A1 (es)
ZA (1) ZA200104581B (es)

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