EA200870575A1 - Композиции и способы лечения застойной сердечной недостаточности - Google Patents
Композиции и способы лечения застойной сердечной недостаточностиInfo
- Publication number
- EA200870575A1 EA200870575A1 EA200870575A EA200870575A EA200870575A1 EA 200870575 A1 EA200870575 A1 EA 200870575A1 EA 200870575 A EA200870575 A EA 200870575A EA 200870575 A EA200870575 A EA 200870575A EA 200870575 A1 EA200870575 A1 EA 200870575A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- compositions
- treatment
- heart failure
- constitual
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем документе предложено применение молекул GLP-1 или его агонистов или аналогов и применение молекул эксендина или его агонистов или аналогов, в том числе производных и активных фрагментов, для профилактики или лечения застойной сердечной недостаточности. Также описаны фармацевтические композиции для применения в способах, описанных в настоящей заявке. Кроме того, предложены композиции и способы для лечения и/или профилактики сахарного диабета, гипергликемии, резистентности к инсулину и ожирения, а также для снижения потребления пищи и подавления аппетита у пациентов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80881006P | 2006-05-26 | 2006-05-26 | |
PCT/US2007/012499 WO2007139941A2 (en) | 2006-05-26 | 2007-05-25 | Composition and methods for treatment of congestive heart failure |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200870575A1 true EA200870575A1 (ru) | 2009-08-28 |
Family
ID=38691932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870575A EA200870575A1 (ru) | 2006-05-26 | 2007-05-25 | Композиции и способы лечения застойной сердечной недостаточности |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100029554A1 (ru) |
EP (2) | EP2035450A2 (ru) |
JP (1) | JP2009538356A (ru) |
KR (1) | KR20090031368A (ru) |
CN (1) | CN101454342A (ru) |
AU (1) | AU2007267833B2 (ru) |
BR (1) | BRPI0712559A2 (ru) |
CA (1) | CA2652907A1 (ru) |
EA (1) | EA200870575A1 (ru) |
IL (1) | IL194975A0 (ru) |
MX (1) | MX2008015107A (ru) |
WO (1) | WO2007139941A2 (ru) |
Families Citing this family (39)
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HUE058307T2 (hu) | 2007-01-08 | 2022-07-28 | Univ Pennsylvania | GLP-1 receptor antagonista veleszületett hiperinzulinizmus kezelésében történõ használatra |
CN104248623B (zh) | 2008-09-04 | 2020-04-03 | 安米林药品有限责任公司 | 使用非水性载体的持续释放制剂 |
PT2373681T (pt) | 2008-12-10 | 2017-04-11 | Glaxosmithkline Llc | Composições farmacêuticas de albiglutida |
KR20120116942A (ko) * | 2009-11-23 | 2012-10-23 | 아밀린 파마슈티칼스, 인크. | 폴리펩티드 접합체 |
WO2011140176A1 (en) | 2010-05-04 | 2011-11-10 | Glaxosmithkline Llc | Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection |
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US20140220134A1 (en) * | 2011-06-24 | 2014-08-07 | Astrazeneca Pharamceuticals LP | Method for treating diabetes with extended release formulation of glp-1 receptor agonists |
JP6006309B2 (ja) | 2011-07-08 | 2016-10-12 | アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals,Llc | 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド |
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US20150111224A1 (en) * | 2012-03-16 | 2015-04-23 | Fatih Arslan | Biomarkers for adverse cardiac remodeling |
CA2875743A1 (en) | 2012-06-14 | 2013-12-19 | Sanofi | Exendin-4 peptide analogues |
UA116217C2 (uk) * | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
JP2016503771A (ja) | 2012-12-21 | 2016-02-08 | サノフイ | エキセンジン−4誘導体 |
US10286078B2 (en) | 2013-09-13 | 2019-05-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
TW201609798A (zh) * | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | Exendin-4胜肽類似物 |
EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
CN106456589B (zh) | 2013-12-18 | 2020-07-07 | 斯克利普斯研究所 | 修饰的治疗剂、订合的肽脂质缀合物及其组合物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
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US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
PL3297654T3 (pl) | 2015-05-22 | 2021-12-20 | The Board Of Trustees Of The Leland Stanford Junior University | Leczenie pobariatrycznej hipoglikemii eksendyną (9-39) |
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-
2007
- 2007-05-25 AU AU2007267833A patent/AU2007267833B2/en not_active Ceased
- 2007-05-25 CN CNA2007800193642A patent/CN101454342A/zh active Pending
- 2007-05-25 EA EA200870575A patent/EA200870575A1/ru unknown
- 2007-05-25 WO PCT/US2007/012499 patent/WO2007139941A2/en active Application Filing
- 2007-05-25 BR BRPI0712559-3A patent/BRPI0712559A2/pt not_active IP Right Cessation
- 2007-05-25 MX MX2008015107A patent/MX2008015107A/es unknown
- 2007-05-25 EP EP07777280A patent/EP2035450A2/en not_active Withdrawn
- 2007-05-25 US US12/301,199 patent/US20100029554A1/en not_active Abandoned
- 2007-05-25 JP JP2009513202A patent/JP2009538356A/ja active Pending
- 2007-05-25 KR KR1020087031082A patent/KR20090031368A/ko not_active Application Discontinuation
- 2007-05-25 EP EP13162980.0A patent/EP2636680A3/en not_active Withdrawn
- 2007-05-25 CA CA002652907A patent/CA2652907A1/en not_active Abandoned
-
2008
- 2008-10-29 IL IL194975A patent/IL194975A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2652907A1 (en) | 2007-12-06 |
US20100029554A1 (en) | 2010-02-04 |
CN101454342A (zh) | 2009-06-10 |
WO2007139941A2 (en) | 2007-12-06 |
JP2009538356A (ja) | 2009-11-05 |
EP2636680A3 (en) | 2013-12-11 |
EP2035450A2 (en) | 2009-03-18 |
EP2636680A2 (en) | 2013-09-11 |
IL194975A0 (en) | 2011-08-01 |
AU2007267833A1 (en) | 2007-12-06 |
BRPI0712559A2 (pt) | 2012-11-20 |
MX2008015107A (es) | 2008-12-09 |
AU2007267833B2 (en) | 2012-07-26 |
WO2007139941A3 (en) | 2008-07-17 |
KR20090031368A (ko) | 2009-03-25 |
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